Effects of dietary stevioside/rebaudioside A on the growth performance and diarrhea incidence of weaned piglets

Wang, L.S.; Shi, Zhan; Shi, Baoming; Shan, A. S.

doi:10.1016/j.anifeedsci.2013.10.014

Cited by 25 publications

(19 citation statements)

References 19 publications

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“…Stevia extract is occasionally used in animal feeding mainly to improve the palatability of the feed and subsequently increase feed intake and body weight gain, particularly in chickens [ 42 ] and pigs [ 43 ]. Our interest in stevia extract stemmed from its 2,5 dihydroxymethyl-3,4-dihydroxypyrrolidine (DMDP) content, a potent glycosidase inhibitor that could prevent the deglycosylation of saponins to sapogenins in the rumen.…”

Section: Discussionmentioning

confidence: 99%

Improving the antiprotozoal effect of saponins in the rumen by combination with glycosidase inhibiting iminosugars or by modification of their chemical structure

et al. 2017

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The antiprotozoal effect of saponins is transitory, as when saponins are deglycosylated to sapogenins by rumen microorganisms they become inactive. We hypothesised that the combination of saponins with glycosidase-inhibiting iminosugars might potentially increase the effectiveness of saponins over time by preventing their deglycosylation in the rumen. Alternatively, modifying the structure of the saponins by substituting the sugar moiety with other small polar residues might maintain their activity as the sugar substitute would not be enzymatically cleaved. The aim of this in vitro study was to evaluate the acute antiprotozoal effect and the stability of this effect over a 24 h incubation period using ivy saponins, a stevia extract rich in iminosugars, ivy saponins with stevia extract, and a chemically modified ivy saponin, hederagenin bis-succinate (HBS). The effects on fermentation parameters and rumen bacterial communities were also studied. Ivy saponins with stevia and HBS had a greater antiprotozoal effect than ivy saponins, and this effect was maintained after 24 h of incubation (P<0.001). The combination of ivy and stevia extracts was more effective in shifting the fermentation pattern towards higher propionate (+39%) and lower butyrate (-32%) and lower ammonia concentration (-64%) than the extracts incubated separately. HBS caused a decrease in butyrate (-45%) and an increase in propionate (+43%) molar proportions. However, the decrease in ammonia concentration (-42%) observed in the presence of HBS was less than that caused by ivy saponins, either alone or with stevia. Whereas HBS and stevia impacted on bacterial population in terms of community structure, only HBS had an effect in terms of biodiversity (P<0.05). It was concluded that ivy saponins with stevia and the modified saponin HBS had a strong antiprotozoal effect, although they differed in their effects on fermentation parameters and bacteria communities. Ivy saponins combined with an iminosugar-rich stevia extract and/or HBS should be evaluated to determine their antiprotozoal effect in vivo.

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Section: Discussionmentioning

confidence: 99%

Improving the antiprotozoal effect of saponins in the rumen by combination with glycosidase inhibiting iminosugars or by modification of their chemical structure

et al. 2017

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“…These compounds have high sweetness but no caloric value [1,2]. STE and RBA in S. rebaudiana also have some biological bioactivities such as antidiabetic [3,4], antioxidant [5,6], antihypertensive [7], antidiarrheal [8], and anticancer [9]. Due to their beneficial effects, stevioside and rebaudioside A were increasingly used in industry [10].…”

Section: Introductionmentioning

confidence: 99%

Quantitative Analysisof Stevioside and Rebaudioside a in Steviarebaudiana Leaves Using Infrared Spectroscopy and Multivariate Calibration

Martono

Rohman

2019

Int J App Pharm

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Objective: The objective of this research was to develop Fourier transform infrared (FTIR) spectroscopy in combination with multivariate analysis of partial least square (PLS) regression for quantitative analysis of stevioside and rebaudioside A in S. rebaudiana leaves extract.Methods: Stevia rebaudiana leaves with various ages were obtained from several high hills in Central Java, Indonesia. The extract samples were scanned using FTIR spectrophotometer in wavenumbers region of 4000–650 cm-1. PLS calibration model was established by plotting the actual value of stevioside and rebaudioside A as determined by high-performance liquid chromatography (HPLC) and FTIR predicted value. The performance of PLS regression was evaluated using coefficient determination (R2), root mean square error of calibration (RMSEC), root mean square error of prediction (RMSEP).Results: PLS regression for stevioside determination was successfully established using the combined wavenumber region of 671–1450 and 3279-3301 cm-1. PLS regression revealed R2of 0.9952with RMSEC value of0.84%. Meanwhile, rebaudioside A was determined at wavenumber region of 921–1508 cm-1using normal spectra. PLS model revealed R2 and RMSEC of 0.9911 and 0.70%, respectively.Conclusion: FTIR spectroscopy in combination with multivariate analysis of PLS regression could be used as an alternative method for quantitative analysis ofstevioside and rebaudioside A in S. rebaudiana leaves.

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“…Por outro lado, existem pesquisas in vitro que demonstram que a Stevia e seus extratos possuem propriedades antibacterianas que podem influenciar a população de microorganismos do intestino (vidaLEs et al, 2013). Wang et al (2014) observaram efeito quadrático (P<0,001) na incidência de diarreia em leitões desmamados alimentados com dietas contendo steviosídeo (0,100,150,200, 250 e 300 mg/kg), sendo que o nível ótimo de inclusão calculado foi de 251,49 mg/kg. Os autores atribuem este efeito à atividade bactericida e antirotavírus da S. rebaudiana.…”

Section: Resultsunclassified

“…Yuanxiao et al (2011) observaram melhores CDR e GDP em leitões alimentados com ração contendo Stevia (70, 100 e 200 g/t) em relação ao grupo controle, além de relatarem melhor aproveitamento da energia, proteína bruta, extrato etéreo, cálcio e fósforo em leitões submetidos aos tratamentos com 100 e 200 g/t. Mais recentemente, Wang et al (2014) verificaram aumento linear (P≤0,05) no GDP em leitões desmamados alimentados com dietas contendo steviosídeo (0,100,150,200, 250 e 300 mg/kg), acompanhado de aumento linear (P<0,05) no CDR e decréscimo linear (P<0,05) na CA.…”

Section: Resultsunclassified

Uso de edulcorante como palatabilizante na dieta de leitões desmamados

Budiño¹,

Lucchesi²,

Otsuk³

2014

Bol. Ind. Anim.

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RESUMO: Objetivou-se determinar os efeitos da adição de um edulcorante a base de Stevia rebaudiana como palatabilizante em dietas de leitões desmamados sobre o desempenho (ganho diário de peso, consumo diário de ração e conversão alimentar) e a incidência de diarreia. Foram utilizados 72 leitões, homogêneos quanto à linhagem (Large White x Landrace), desmamados aos 23 dias de idade, pesando em média 7,60 ± 0,90 kg. Foi utilizado o delineamento em blocos completos casualizados, sendo que a unidade experimental foi constituída por dois animais, submetidos a quatro tratamentos com nove repetições cada. Os animais, em grupos de dois (macho castrado e fêmea) foram alojados em baias metálicas suspensas. O desempenho dos leitões foi avaliado no período I (23 a 37 dias de idade), período II (37 a 51 dias de idade), período III (51 a 65 dias de idade) e período total (23 a 65 dias de idade). Os tratamentos consistiram de rações contendo níveis crescentes (0,00; 0,125; 0,250 e 0,500%) de inclusão de edulcorante. Esses níveis de inclusão foram utilizados nos períodos I e II, enquanto no período III as inclusões de edulcorante foram reduzidas em 50%, ou seja, 0,00, 0,0625, 0,125 e 0,250%, respectivamente. Não ocorreram casos graves de diarreia nos primeiros 15 dias do ensaio nos tratamentos estudados. Não foram observadas diferenças significativas (P>0,05) em nenhuma das variáveis de desempenho estudadas nos períodos I, II e total. Durante o período III, houve efeito quadrático tanto no ganho diário de peso (P=0,0158) quanto na conversão alimentar (P=0,0252). A adição de palatabilizante a base de Stevia na dieta de leitões desmamados influenciou o desempenho destes dos 51 aos 65 dias de idade, sendo que o nível ótimo calculado de inclusão do edulcorante que proporcionou melhores ganho diário de peso e conversão alimentar foi de 0,265 e 0,286%, respectivamente.Palavras-chave: desempenho, diarreia, Stevia rebaudiana. USE OF SWEETENER AS A PALATABILITY IN DIETS OF WEANED PIGLETSABSTRACT: This study aimed to determine the effects of adding a sweetener based upon Stevia rebaudiana as palatability in diets of weaned piglets evaluating performance (average daily gain, feed intake and feed conversion ratio) and diarrhea occurrence. Seventy-two piglets were used from a homogeneous strain (Large White x Landrace) weaned at 23 days of age, weighing an average of 7.60 ± 0.90 kg. The animals in groups of two (barrow and female) were housed in elevated metal pens. The performance of piglets was assessed in period I (23 to 37 days of age), period II (37 to 51 days of age), period III (51 to 65 days of age), and total period (23 to 65 days of age). The treatments were: 0.0% inclusion of the sweetener, 0.125% inclusion of the sweetener, 0.250% inclusion of the sweetener, 0.500% inclusion of the sweetener. Since these inclusion levels were used in periods I and II, period III the inclusions of the sweetener were reduced by 50%, or 0.00, 0.0625, 0.125 and 0.250%, respectively. There were no cases of severe diarrhea in the first 15 days of tes...

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Effects of dietary stevioside/rebaudioside A on the growth performance and diarrhea incidence of weaned piglets

Cited by 25 publications

References 19 publications

Improving the antiprotozoal effect of saponins in the rumen by combination with glycosidase inhibiting iminosugars or by modification of their chemical structure

Improving the antiprotozoal effect of saponins in the rumen by combination with glycosidase inhibiting iminosugars or by modification of their chemical structure

Quantitative Analysisof Stevioside and Rebaudioside a in Steviarebaudiana Leaves Using Infrared Spectroscopy and Multivariate Calibration

Uso de edulcorante como palatabilizante na dieta de leitões desmamados

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