Effects of Aluminium–Magnesium Silicate on <i>Newcastle Disease Virus</i> and on recovery of infected chicks

Abstract

Effect of a synthetic Aluminium-Magnesium Silicate (AMS) on Newcastle Disease Virus (NDV) was tested. Equal amounts, of the AMS and of NDV, on a volume to weight (v/w) basis, were incubated for one hour at room temperature, and then centrifuged. The supernatant was tested for NDV titre. Portions of a virulent NDV were similarly incubated with the AMS, and their supernatants tested for morbidity rates on infected chicks. Also, two groups of chicks were infected with virulent NDV intramuscularly (I/m), and by introduction of infected chicks, respectively. Their subgroups were treated by administering AMS through drinking water, to assess its effect on mortality. Incubating NDV with AMS, reduced the viral titre from mean HA, 613 ±86 to 4. 5 ±0.72 (P < 0.05). Also, incubating virulent NDV with the AMS, reduced its morbidity rate from 100% to 20% (P< 0.05) when incubated once, and from 100% to zero, when incubated twice. NDV-infected chicks treated with AMS, had same 100% mortality as the controls, when route of infection was I/m (P > 0.05) but when infection was by introduction of infected chicks, mortality reduced from 20% to zero (P < 0.05).These results suggest AMS as NDV's antiviral agent.

Antiviral effects of a synthetic Aluminium-Magnesium Silicate, on Avian Influenza Virus

“…This suggests that the electrostatic attraction between the AMS molecules and the viral particles was stronger than that between them and water molecules. [16]. AMS is safe when ingested by man and by animals [5,17].…”

Synergy in antibacterial activities of Ampicillin trihydrate, stabilized with a synthetic aluminum-magnesium silicate and immune-stimulants, on resistant &lt;i&gt;Escherichia coli&lt;/i&gt; infection

“…The Synthetic AMS has been used for in vivo experiments with chicks, dogs, mice and rats [18][19][20][21][22][23][24][25] without adverse side effects on treated animals. It may therefore be possible to minimize immune suppression due to Ampicillin [1] by reducing its dose and use The Synthetic AMS to improve antibacterial activity of the lower doses.…”

Reducing Side Effects of Chloroquine with &lt;i&gt;Medicinal Synthetic Aluminum-Magnesium Silicate&lt;/i&gt;&amp;reg; [Msams: Al&lt;sub&gt;4&lt;/sub&gt;(SiO&lt;sub&gt;4&lt;/sub&gt;)&lt;sub&gt;3&lt;/sub&gt; + 3Mg&lt;sub&gt;2&lt;/sub&gt;SiO&lt;sub&gt;4&lt;/sub&gt; →2Al&lt;sub&gt;2&lt;/sub&gt;Mg&lt;sub&gt;3&lt;/sub&gt;(SiO&lt;sub&gt;4&lt;/sub&gt;)&lt;sub&g

“…The finding that when antimicrobial medicines are stabilized with the Medicinal synthetic Aluminum-magnesium silicate, their best therapeutic effects are obtained with 75% (not 100%) of their recommended doses, has been consistent with all the medicines so far tested. The treatment-strategy improved anti-protozoal and antibacterial efficacies of Suphadimidine, anthelminthic efficacy of Piparazine and antibacterial efficacies of Ampicillin and Cotrimoxazole [14]- [19].…”