Effectiveness of the Local Application of 1% Tioconazole in the Treatment of Bovine Dermatophytosis

Abstract

SummaryThis study consisted of twenty-five dermatophytotic cattle, aged 1.5-11 months obtained from Kars province and its surrounding, diagnosed as dermatophytosis following clinical and microbiologically. All animals were divided into two groups; trial group (n=15) and control group (n=10). The skin lesions of the trial animals were treated using a pomade containing 1% tioconazole once daily for a period of 5 days. In 12 of the trial animals the amount of keratinized tissue found in the dermatophytosis lesions decreased significantly following the 3 rd application and had disappeared completely after the 5 th application. On the other hand, the remaining 3 animals in the trial group were applied the medicament seven times due to the persistence of keratinized tissue in the lesions. In all of the animals administered with tioconazole, new hair growth in the site of the lesions resumed in the 3 rd -4 th weeks and complete recovery occurred within 7-8 weeks. In conclusion, 1% tioconazole, used for the first time for the treatment of bovine dermatophytosis in this study was found to be rather effective owing to its ease of application and strong therapeutic effect. Keywords: Cattle, Dermatophytosis, Tioconazole Sığır Dermatofitozisinin Tedavisinde %1'lik Tiokonazol'ün Lokal Kullanımının Etkinliği ÖzetÇalışma materyalini, Kars ve çevre köylerinden sağlanan, 1,5-11 aylık yaşta, klinik ve mikrobiyolojik olarak dermatofitozis tanısı konulan 15 deneme ve 10 kontrol olmak üzere, toplam 25 sığır oluşturdu. Deneme grubundaki hayvanların derilerindeki lezyonların üzerine %1 tiokonazol içeren kremden 5 gün boyunca günde 1 kez sürüldü. Deneme grubundaki hayvanlardan 12'sinde 3. uygulamayı takiben, dermatofitoz lezyonlarındaki keratinize dokuların büyük oranda azaldığı, 5. uygulama sonunda ise tamamen kaybolduğu görülürken 3 hayvanda keratinize doku dökülmediği için 7. uygulamaya gidildi. İlaç uygulanan tüm hayvanlarda lezyonlu bölgelerde 3-4. haftalarda kıllanmanın başladığı, 7-8. haftalarda ise tamamen iyileştiği görüldü. Sonuç olarak, sığırlarda dermatofitozis olgularının tedavisinde ilk olarak denenen %1'lik tiokonazol'ün, kullanımının kolay olması ve tedavi edici etkisinin yüksek olması nedeniyle, sığırlarda dermatofitozis olgularının sağaltımında oldukça etkili bulunmuştur.

Efficacy of pomades containing different percentages of enilconazole in the treatment of bovine dermatophytosis

“…Bovine dermatophytosis is an important skin disease that has an economic significance and important public health considerations for cattle and farmers. Trichophyton verrucosum is the most common isolate from cattle with dermatophytosis and was most frequently isolated from cattle in this report . Various medical and vaccine treatment options exist for the management of bovine dermatophytosis with varying practical and economic considerations .…”

“…Dermatophytosis is an important zoonotic disease of humans and animals . In cattle, dermatophytosis is most frequently caused by Trichophyton verrucosum . Clinical lesions are characterized by nonpruritic, multifocal lesions of alopecia with scale .…”

The Treatment of Ringworm with Silver Nitrate Pencil in Cattle: Only One Application

“…Medication cannot penetrate the crusts; the crusts should be removed by scraping or brushing. Lesion should be treated at least twice, three to five days apart (15,16,24). In present study, crusts were removed by scraping, later silver nitrate pencil application was made only for once.…”

“…Systemic applications are including; ivermectin, ethylenediamine dihydriodide orally, griseofulvine orally (11,12,14). Topical applications are including; thiabendazole was made in glycerine, tincture of iodine, 1% tioconazole, 10% enilconazole, propolis ointment, Whitfield's ointment, propolis and Whitfield's ointment, miconazole ointments, garlic solution, zinc oxide, salicylic acid + benzoic acid + sulfur + iodine and vaseline combination (4,5,15,16,17,18,19,20). Topical applications should be made 3-4 times.…”

A study on the use of henna plant (Lawsonia inermis Linn) for the treatment of fungal disease (Trichophypton verrucosum) in calves

“…Ponugoti, (2018) reported this finding suggested that henna extract may be used as an alternative source of antifungal agent for the protection of fungal infection. Başoğlu et al, (1998), Kırmızıgül et al (2008aKırmızıgül et al ( , 2009bKırmızıgül et al ( , 2013c, Cam et al, (2009) repoted that systemic antifungal and topical treatment were used for the treatment of wounds caused by dermatophytes. In a study has done with henna by Muhammed H and Muhammed S, (2005) reported that the mixture of powder henna leaves with water prevents the wound from growing in burns.…”