Effectiveness of amikacin administered by autoinjector compared to manual injection on infected excision wound model of Wistar rats

Abstract

To evaluate the effectiveness of amikacin administered by autoinjector compared to manual injection on infected excision wound model of Wistar rats. Randomly bred 14 Wistar rats of either sex weighing 180 to 230 g were used for the present study. The study has the approval of the Institutional Animal Ethical Committee. Pseudomonas aeruginosa was used for infecting the wounds.1 mL of blood was withdrawn aseptically from the orbital sinus under isoflurane anaesthesia, and the biochemical parameters were carried out. All results were expressed as mean ± SEM, and the results were compared statistically by one-way ANOVA using Sigma Plot 13. P-value < 0.05 was considered statistically significant. The biochemical parameters in the study was more or less similar. The infected rats treated with amikacin showed faster wound contraction compared to control. This study concludes the effectiveness of amikacin administered through autoinjectors and manual injection in infected excision wound model as similar. Therefore, amikacin autoinjector is a better choice to manual injection to overcome from wound infections if it is administered at the right time in case of emergency or whenever required. Injury and wound infection are common in natural and manmade disasters. Serious bacterial wound infections are a potential threat to open injuries. As accessibility to the primary health centre or hospital may not be easy or possible during disasters and to overcome such a situation, an antibacterial autoinjector would be useful.

Polyester-based ink platform with tunable bioactivity for 3D printing of tissue engineering scaffolds

“…In addition, the polymer must have a fast melt to solid phase transformation (within minutes) to rapidly melt in the hot nozzle and rapidly solidify when extruded from the nozzle. 30,32 For instance, PLA, the most widely used polymer in 3D printing, shows a fast phase transformation, indicated by a sharp drop in G' within a very narrow temperature window (Figure 5). For commercial PLA, solid to melt transition occurred at T sm = 180 ˚C and melt viscosity was equal to 8.4×10 5 mPa.s above 180 ˚C (usual printing temperature).…”

“…31 In addition, the polymer must have a reversible and fast melt to solid phase transformation (within minutes) to rapidly melt in the hot nozzle and to rapidly solidify when extruded from the nozzle. 32 In addition to printability, the ideal polymeric biomaterial should have sufficient mechanical properties (stiffness, toughness, etc.) to provide structural integrity, thereby enabling direct implantation, and should be biodegradable to allow replacement of the scaffold by newly grown tissue.…”