The rapid emergence of nanoelectronics, with the consequent rise in transistor density and switching speed, has led to a steep increase in chip heat flux and growing concern over the emergence of onchip "hot spots" in microprocessors, along with such high flux regions in power electronic chips and LED's. Miniaturized thermoelectric coolers (μ-TEC's) are a most promising cooling technique for the remediation of such hot spots. This paper presents a comprehensive review of recent advances in novel applications of superlattice, mini-contact, and silicon-based miniaturized thermoelectric coolers in reducing the severity of onchip hot spots.