Effect of Camel Milk’s Supplementation on Serum Glucose Levels, Lipid Profile and Body Weight of Alloxan-Induced Diabetic Rats

Isa, Suleiman Ahmed; Ibrahim, Kasimu Ghandi; Abubakar, Ibrahim

doi:10.4314/njbas.v21i3.3

Cited by 5 publications

(3 citation statements)

References 24 publications

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“…This increase in TG might be due to the shortage of insulin under diabetic condition. The obtained result came in agreement with those of Arkkila et al 2001, Hassan & Emam, 2012and Isa et al, (2013. These results are in agreement with previous reports (Hassan & Emam, 2012;and Isa et al, 2013) and in the data presented in figure (1).…”

Section: Biochemical Analyses: Serum Biochemical Analysessupporting

confidence: 93%

Biological Attributes of Unfermented and Fermented Oat Milk Compared to Cow Milk in Alloxan-Induced Diabetic Rats

Gohari

El-Batawy

Mahdy

2019

Journal of Food and Dairy Sciences

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The present study aimed to assess the therapeutic effect of the unfermented and fermented cow; oat milk (CM, OM, FCM, and FOM) and fermented oat milk supplemented with 2% whey protein concentrate (FOM+WP) in diabetic rats. Alloxan was applied for inducing diabetes and hyperlipidemia in rats. The rats were randomly divided into two main groups. Control (-) (6 rats) were fed on a standard diet, while the second group (42 diabetics rats) were divided into six groups (6 rats each), and treated by different unfermented and fermented milk types by epigastric tube for 4 weeks. After four weeks, all treatments reduced the level of glucose, the serum levels of TC, TG and LDL-c compared to control (+) group and this was associated with a significant increase (p<0.05) in HDL-c in these groups. The highest significantly (p<0.05) decrease recorded in the groups fed with (OM) and (FCM), respectively. Liver enzymes activity decreased significantly (P˂0.05) in FOM + WP, FOM, FCM and OM groups, respectively. Feeding the rats on fermented oat milk fortified with whey protein led to decrease the fecal total anaerobes and fecal enterobacterial counts and stimulate the viability of both fecal lactobacilli and bifidobacteria in the intestinal colon, compared with other treatments. Histopathological examination of the liver sections showed no histopathological alteration in the hepatic parenchyma in (FOM+WP) group. (OM) and (FCM) groups showed no histopathological alteration and the islands of Langerhans cells were in normal size as well as the surrounding acini and ducts. In conclusion, treatment with oat milk led to curing hyperglycemia and hyperlipidemia in diabetic rats. Meanwhile, treatment with fermented oat milk fortified with whey proteins resulted in a better effect on the liver and improved the growth of the health-promoting intestinal microflora.

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Section: Biochemical Analyses: Serum Biochemical Analysessupporting

confidence: 93%

Biological Attributes of Unfermented and Fermented Oat Milk Compared to Cow Milk in Alloxan-Induced Diabetic Rats

Gohari

El-Batawy

Mahdy

2019

Journal of Food and Dairy Sciences

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“…This ability could be due to the release of bioactive peptides from the CM proteins that show inhibitory activity against important carbohydrase enzymes (α-amylase and α-glucosidase). Additionally, some reports have observed an insulin-like substance in CM that supports its ability to prevent and control diabetes (Mihic et al, 2016;Isa et al, 2013).…”

Section: Discussionmentioning

confidence: 93%

Reduction of Lipid Profile and Adipocyte Size in Rats Fed on High-fat Diet Using Camel Milk and Whey Protein Mixture

Althwab

Alsudais

Mousa

et al. 2020

FSTR

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The aim of this study was to examine the effect of oral administration of Camel milk (CM) and whey protein (WP) (1.5 % and 3.0 % in water) -either alone or in a mixture -on obesity parameters and lipid profile in rats fed on a high-fat diet. The results revealed that feeding rats on CM or WP significantly reduced body weight gain, adipocyte size and the weight of perirenal adipose tissue, especially when CM was mixed with 1.5 % WP. Feeding rats on CM, WP or a mixture of CM and WP led to a significant reduction ( p < 0.05) in the levels of LDL and total cholesterol and an improvement ( p < 0.05) in the fasting glucose levels. In conclusion, consumption of CM, WP or a mixture of CM and WP reduced the number of large adipocytes and increased the number of small adipocytes, resulting in reduction of the body weight of the rats.

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“…For instance, camel milk was proposed as an adjunct to insulin-based therapy allowing the reduction of insulin doses required in patients with type 1 diabetes ( 12 , 14 , 19 ). This suggests that the anti-diabetic activity of camel milk is mediated by an insulin-like and/or immune-modulatory effects on beta-cells of the pancreas ( 17 ). The amino acid sequence of some proteins isolated from camel milk has been reported to be rich in half-cystine, which implies a similarity with insulin family of peptides ( 20 ).…”

Section: Introductionmentioning

confidence: 99%

Differential Effects of Camel Milk on Insulin Receptor Signaling – Toward Understanding the Insulin-Like Properties of Camel Milk

et al. 2016

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Previous studies on the Arabian camel (Camelus dromedarius) showed beneficial effects of its milk reported in diverse models of human diseases, including a substantial hypoglycemic activity. However, the cellular and molecular mechanisms involved in such effects remain completely unknown. In this study, we hypothesized that camel milk may act at the level of human insulin receptor (hIR) and its related intracellular signaling pathways. Therefore, we examined the effect of camel milk on the activation of hIR transiently expressed in human embryonic kidney 293 (HEK293) cells using bioluminescence resonance energy transfer (BRET) technology. BRET was used to assess, in live cells and real-time, the physical interaction between hIR and insulin receptor signaling proteins (IRS1) and the growth factor receptor-bound protein 2 (Grb2). Our data showed that camel milk did not promote any increase in the BRET signal between hIR and IRS1 or Grb2 in the absence of insulin stimulation. However, it significantly potentiated the maximal insulin-promoted BRET signal between hIR and Grb2 but not IRS1. Interestingly, camel milk appears to differentially impact the downstream signaling since it significantly activated ERK1/2 and potentiated the insulin-induced ERK1/2 but not Akt activation. These observations are to some extent consistent with the BRET data since ERK1/2 and Akt activation are known to reflect the engagement of Grb2 and IRS1 pathways, respectively. The preliminary fractionation of camel milk suggests the peptide/protein nature of the active component in camel milk. Together, our study demonstrates for the first time an allosteric effect of camel milk on insulin receptor conformation and activation with differential effects on its intracellular signaling. These findings should help to shed more light on the hypoglycemic activity of camel milk with potential therapeutic applications.

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Effect of Camel Milk’s Supplementation on Serum Glucose Levels, Lipid Profile and Body Weight of Alloxan-Induced Diabetic Rats

Cited by 5 publications

References 24 publications

Biological Attributes of Unfermented and Fermented Oat Milk Compared to Cow Milk in Alloxan-Induced Diabetic Rats

Biological Attributes of Unfermented and Fermented Oat Milk Compared to Cow Milk in Alloxan-Induced Diabetic Rats

Reduction of Lipid Profile and Adipocyte Size in Rats Fed on High-fat Diet Using Camel Milk and Whey Protein Mixture

Differential Effects of Camel Milk on Insulin Receptor Signaling – Toward Understanding the Insulin-Like Properties of Camel Milk

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