Biological Attributes of Unfermented and Fermented Oat Milk Compared to Cow Milk in Alloxan-Induced Diabetic Rats

Abstract

The present study aimed to assess the therapeutic effect of the unfermented and fermented cow; oat milk (CM, OM, FCM, and FOM) and fermented oat milk supplemented with 2% whey protein concentrate (FOM+WP) in diabetic rats. Alloxan was applied for inducing diabetes and hyperlipidemia in rats. The rats were randomly divided into two main groups. Control (-) (6 rats) were fed on a standard diet, while the second group (42 diabetics rats) were divided into six groups (6 rats each), and treated by different unfermented and fermented milk types by epigastric tube for 4 weeks. After four weeks, all treatments reduced the level of glucose, the serum levels of TC, TG and LDL-c compared to control (+) group and this was associated with a significant increase (p<0.05) in HDL-c in these groups. The highest significantly (p<0.05) decrease recorded in the groups fed with (OM) and (FCM), respectively. Liver enzymes activity decreased significantly (P˂0.05) in FOM + WP, FOM, FCM and OM groups, respectively. Feeding the rats on fermented oat milk fortified with whey protein led to decrease the fecal total anaerobes and fecal enterobacterial counts and stimulate the viability of both fecal lactobacilli and bifidobacteria in the intestinal colon, compared with other treatments. Histopathological examination of the liver sections showed no histopathological alteration in the hepatic parenchyma in (FOM+WP) group. (OM) and (FCM) groups showed no histopathological alteration and the islands of Langerhans cells were in normal size as well as the surrounding acini and ducts. In conclusion, treatment with oat milk led to curing hyperglycemia and hyperlipidemia in diabetic rats. Meanwhile, treatment with fermented oat milk fortified with whey proteins resulted in a better effect on the liver and improved the growth of the health-promoting intestinal microflora.

Fermented Oats as a Novel Functional Food

“…Gohari and colleagues [ 84 ] conducted a study to investigate the potential anti-diabetic and hypolipidemic effects of unfermented and fermented oat milk in alloxan-induced diabetic rats. The study employed forty-two male Albino rats as the animal model, inducing diabetes using alloxan.…”

Plant-Based Dairy Alternatives—A Future Direction to the Milky Way

“…To support the statement, an experimental study conducted on 42 diabetic rats evidenced the therapeutic potential of both fermented and unfermented oat milk alternatives. The study's main outcome showed an improvement in intestinal microbiota diversity and pointed out the lower risk of developing hyperglycemia and hyperlipidemia associated with type 2 diabetes mellitus [178]. In addition, PBDAs based on oat lower the serum and LDL cholesterol levels after moderate consumption, facts evidenced in a study conducted on 52 free-living men with moderate hypercholesterolemia who consumed 750 mL/day of oat milk for 5 weeks [179].…”

“…Plant-based dairy drinks such as oat milk alternatives have health benefits in alleviating diabetes-associated symptoms and hyperlipidemia [178]. To support the statement, an experimental study conducted on 42 diabetic rats evidenced the therapeutic potential of both fermented and unfermented oat milk alternatives.…”

Local and Systemic Effects of Bioactive Food Ingredients: Is There a Role for Functional Foods to Prime the Gut for Resilience?

“…Two rat studies highlight the anti-diabetic effects of fermented oat milk, improving glucose control, lipid metabolism, and liver health and influencing intestinal microbiota composition [ 186 , 187 ]. Notably, one study underscores the synergistic impact of fermented oats and Sidr honey in diabetic rats, with enhanced anti-diabetic effects compared to fermented oats alone [ 186 ].…”