Dynamic thiol/disulphide homeostasis in patients with Uterine Myoma

Eroğlu, Semra; Haskul, Ismail; Aziz, Vusale; Yurtcu, Engin; Karataş, Fatih; Neşeli̇oğlu, Salim; Erel, Özcan

doi:10.1016/j.ejogrb.2017.06.045

Cited by 14 publications

(14 citation statements)

References 20 publications

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“…In patients with uterine myoma it has been demonstrated that NT, TT and disulfide levels were found to be lower than healthy control subjects. These results have been commented that proliferative phase of uterine myoma might be a possible cause and disulfide levels were found to be lower than control group [87].…”

Section: Obstetric and Gynecologic Disordersmentioning

confidence: 76%

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Erel

Erdoğan

2020

Turk J Med Sci

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Dynamic thiol-disulfide homeostasis (TDH) is a new area has begun to attract more scrutiny. Dynamic TDH is reversal of thiol oxidation in proteins and represents the status of thiols (-SH) and disulfides (-S-S-). Organic compounds containing the sulfhydryl group is called thiol, composed of sulfur and hydrogen atoms. Disulfides are the most important class of dynamic, redox responsive covalent bonds build in between two thiol groups. For many years, thiol levels were analyzed by several methods. During last years, measurements of disulfide levels have been analyzed by a novel automated method, developed by Erel and Neselioglu. In this method, addition to thiol-termed as native thiol-levels, disulfide levels were also measured and sum of native thiol and disulfide levels were termed as total thiol. Therefore, TDH was begun to be understood in organism. In healthy humans, TDH is maintained within a certain range. Dysregulated dynamic TDH has been implicated several disorders with unknown etiology. A growing body of evidence has demonstrated that the thiol-disulfide homeostasis is involved in variety diseases, such as diabetes mellitus, hypertension, non-small cell lung cancer, Familial Mediterranean fever, inflammatory bowel diseases, occupational diseases, gestational diabetes mellitus and preeclampsia. These results may elucidate some pathogenic mechanism or may be a predictor indicating diagnostic clue, prognostic marker or therapeutic sign. In conclusion, protection of the thiol disulfide homeostasis is of great importance for the human being. Evidence achieved so far has proposed that thiol-disulfide homeostasis is an important issue needs to elucidate wholly.

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Section: Obstetric and Gynecologic Disordersmentioning

confidence: 76%

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Erel

Erdoğan

2020

Turk J Med Sci

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“…The resulting disulfide bond structures are again reduced to thiol groups so that the thiol/disulfide balance is maintained [ 7 ]. Diseases including diabetes mellitus [ 8 ], obesity [ 9 ], cardiovascular disease [ 10 ], hypertension [ 11 ], malignancy [ 12 ], rheumatic disease, chronic renal failure [ 13 ], Alzheimer's disease [ 14 ], chronic liver disease [ 15 ], cerebral ischemia [ 16 ], nasal polyposis [ 17 ], preeclampsia [ 18 ], uterine myoma [ 19 ], cataracts [ 20 ], chronic radiation exposure [ 21 ], and acute tonsillopharyngitis [ 22 ] have been assessed by the same method used in our study, and a close relationship with oxidative stress was detected. A strong association between familial hypercholesterolemia and premature atherosclerotic cardiovascular disease was established in a study conducted with 1,690 patients [ 1 ], and, in our study, we found that disulfide formation was elevated in patients with familial hypercholesterolemia.…”

Section: Discussionmentioning

confidence: 99%

Thiol/Disulfide Balance in Patients with Familial Hypercholesterolemia

Özdemir-Şimşek

Çarlıoğlu

Alışık

et al. 2018

Cardiology Research and Practice

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Objective Herein, we investigated the balance of thiol/disulfide, with the hypothesis that the balance between disulfides and thiols, which are natural antioxidants, might be disrupted in patients with familial hypercholesterolemia, which eventually leads to endothelial damage. Methods In this study, we evaluated 51 patients diagnosed with familial hypercholesterolemia and 81 healthy subjects. Blood samples were taken from the patients after a minimum of 12 hours of fasting; samples were immediately centrifuged, stored in Eppendorf tubes, and preserved at −80°C. Results This study found that thiol levels are significantly lower in patients with familial hypercholesterolemia, whereas disulfide levels are higher (independent of age, gender, and body mass index). This means that in such patients, the thiol/disulfide balance changes in favour of disulfide. Conclusions In this study, we found that the thiol/disulfide balance in patients with familial hypercholesterolemia is disrupted in favour of disulfide.

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“…TDH balance has shifted to form disulphide in some diseases such as familial Mediterranean fever (15), celiac disease (16) and febrile seizures (17), on the other hand, the balance has turned to form thiol in basal cell carcinoma (18). Beside this, in case of uterine myoma, THD balance has been broken down (19).…”

Section: Introductionmentioning

confidence: 99%