Thiol/Disulfide Balance in Patients with Familial Hypercholesterolemia

Özdemir-Şimşek, Özgür; Çarlıoğlu, Ayşe; Alışık, Murat; Edem, Efe; Bıçer, Cemile

doi:10.1155/2018/9042461

Cited by 8 publications

(7 citation statements)

References 21 publications

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“…Many recent publications have evaluating the correlation between oxidative stress, and obesity [29][30][31][32]. Although this condition is thought to be caused by deterioration of oxidant-antioxidant equilibrium as a result of increased inflammation and body distribution along with obesity, there are also studies that have not been found to correlate with BMI and oxidative stress [33,34]. In our study, We found a significant correlation between BMI, totol thiol and native thiol.…”

Section: Discussionsupporting

confidence: 44%

Thiol/disulphide homeostasis in Helicobacter pylori infected patients

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Bıçer

Gerçeker³

et al. 2019

The European Research Journal

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Objectives:The aim of the study was to evaluate the oxidative stress level in patients, diagnosed with H. pylori infection, using a novel marker (thiol/disulphide homeostasis) and to compare the level in infected individuals with that in healthy volunteers. Methods: A total of 60 patients diagnosed with gastritis, erosive gastritis or ulcer by endoscopy were included and biopsied. The 30 patients diagnosed with H. pylori and 30 healthy individuals were enrolled. Medical histories, physical examination results, body mass index (BMI), hemogram, free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), urea, creatinin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin, total cholesterol, triglycerides, high density lipoprotein (HDL), low density lipoprotein) LDL and thiol/disulphide levels obtained in the study groups were compared. Results: There was no significant difference between the total thiol, native thiol, disulphide/native thiol and dissulphide/total thiol ratios of the patient and control group. When the H. pylori patients were stratified by endoscopic evaluation as having mild (superficial gastritis or normal appearance) or severe (ulcer or erosive areas) symptoms, there were significant differences in disulphide, disulphide/native thiol, disulphide/total thiol and native thiol/total thiol levels. We also observed BMI and the total, native thiol levels of H. pylori patients were inversely related.( r: 0.562, p = 0.001; r: 0.0552, p = 0.002). Conclusions: Thiol/disulphide homeostasis is likely to differ with both duration and severity of H. pylori infection. Further investigations are needed to investigate the effect of H. pylori on oxidative stress.

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Section: Discussionsupporting

confidence: 44%

Thiol/disulphide homeostasis in Helicobacter pylori infected patients

Baykan

Bıçer

Gerçeker³

et al. 2019

The European Research Journal

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“…The plasma thiol signaling network has been subject to investigation in several other diseases, including CVD, acute and chronic renal failure, diabetes mellitus, familial hypercholesterolemia, and rheumatoid arthritis (Banne et al, 2003; Giustarini et al, 2005; Wlodek et al, 2006; Kundi et al, 2015; Qian et al, 2015; Ates et al, 2016; Koning et al, 2016; Cortese-Krott et al, 2017; Otal et al, 2018; Simsek et al, 2018). In all these studies, significant disturbances of the plasma thiol/disulfide balance were reported, with increased oxidized thiol forms (disulfides) and decreased free thiols, as compared to healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

Crohn’s Disease in Clinical Remission Is Marked by Systemic Oxidative Stress

et al. 2019

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Introduction: Crohn’s disease (CD) is characterized by chronic and relapsing inflammation of the gastro-intestinal tract. It is assumed that oxidative stress contributes to CD pathogenesis, but systemic biomarkers for oxidative stress in CD are not yet identified. A reduction in free thiol groups in plasma proteins (“plasma free thiols”) reflects systemic oxidative stress since they are prime substrates for reactive oxygen species. Here, we determined the concentrations of plasma free thiols in CD patients and healthy controls and studied the putative correlation with disease parameters. Methods: Free thiols were quantified in plasma of patients with CD in clinical remission [according to the Harvey Bradshaw Index (HBI)] and healthy controls and adjusted for plasma albumin. Albumin-adjusted free thiol concentrations were analyzed for associations with clinical and biochemical disease markers. Results: Mean plasma free thiol concentrations were significantly lower in patients with CD ( n = 51) compared to healthy controls ( n = 27) (14.7 ± 2.4 vs. 17.9 ± 1.8 μmol/g albumin; P < 0.001). Patients with CD with above-average free thiols had significantly lower CRP levels (median 1.4 [interquartile range] [0.4; 2.6] vs. 3.6 [0.6; 7.0] mg/L; P < 0.05) and BMI (23.6 ± 4.8 vs. 27.1 ± 5.2 kg/m 2 ; P < 0.05). Patients with CD having solely colonic disease demonstrated markedly reduced plasma free thiol concentrations compared to patients with ileocolonic involvement (13.2 ± 1.8 vs. 15.2 ± 2.2 μmol/g; P < 0.05). Finally, plasma free thiol concentrations negatively correlated with biomarkers of inflammation, including hsCRP, SAA, IL-17A (all P < 0.05), and VEGF. Conclusion: Plasma free thiols are reduced in patients with CD in clinical remission compared to healthy controls. Thus, subclinical CD disease activity is reflected by systemic oxidative stress and plasma free thiols may be a relevant therapeutic target and biomarker to monitor disease activity in CD.

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“…9 The relationship of thiol disulfide balance to various disorders and conditions such as cardiopulmonary diseases, diabetes, myomas, labor, molar pregnancies, hypercholesterolemia and idiopathic recurrent pregnancy loss has rarely been evaluated. [10][11][12][13][14][15][16] Although thiol disulfide balance has been investigated in certain types of cancer such as breast, prostate, colon and basal cell cancer, the possible mechanism through which it may be related to carcinogenesis has not been determined. [17][18][19][20] Although various oxidative stress parameters have been studied in patients with endometrial cancer, 21 dynamic thiol disulfide balance has not previously been studied in such patients.…”

Section: Introductionmentioning

confidence: 99%

“…Using this method, thiol disulfide parameters can be measured practically and precisely 9 . The relationship of thiol disulfide balance to various disorders and conditions such as cardiopulmonary diseases, diabetes, myomas, labor, molar pregnancies, hypercholesterolemia and idiopathic recurrent pregnancy loss has rarely been evaluated 10–16 . Although thiol disulfide balance has been investigated in certain types of cancer such as breast, prostate, colon and basal cell cancer, the possible mechanism through which it may be related to carcinogenesis has not been determined 17–20 …”

Section: Introductionmentioning

confidence: 99%

Assessment of thiol disulfide balance in early‐stage endometrial cancer

Sezgin

Pirinççi

Camuzcuoğlu

et al. 2020

J of Obstet and Gynaecol

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Aim: We carried out this research to assess thiol disulfide balance in patients with early-stage endometrial cancer. Methods: Fifty-seven endometrial cancer patients and 60 age-matched healthy subjects volunteered for this study. Thiol disulfide parameters and the ratios of these parameters were examined using a colorimetric system. We also evaluated total antioxidant capacity, total oxidant capacity and oxidative stress index. Results: Subjects with endometrial cancer had statistically significantly lower serum native thiol and total thiol levels (224.2 [122.8-267.5] and 270.5 [171.6-323.2], respectively) than healthy subjects (281.35 [213.45-358.9] and 339. 55 [274.1-425.95], respectively) (P = 0.001, P < 0.001). Subjects with endometrial cancer had statistically significantly higher serum disulfide/native thiol and disulfide/total thiol ratios (12.22 [8.77-17.61] and 9.82 [7.46-13.02], respectively) than healthy subjects (8.9 [6.79-16.35] and 7.36 [5.9-12.32], respectively) (P = 0.038, P = 0.028). Disulfide/native thiol ratio appeared to be strongly and positively correlated with the stage of endometrial cancer (r = 0.827, P < 0.001). Conclusion: This is an initial report related to thiol disulfide balance in endometrial cancer patients. We believe that oxidative stress contributes both to the evolution and to the progression of the disease. We conclude that deterioration of thiol disulfide balance due to oxidative stress is likely to contribute to the etiopathogenesis of endometrial cancer.

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Thiol/Disulfide Balance in Patients with Familial Hypercholesterolemia

Cited by 8 publications

References 21 publications

Thiol/disulphide homeostasis in Helicobacter pylori infected patients

Thiol/disulphide homeostasis in Helicobacter pylori infected patients

Crohn’s Disease in Clinical Remission Is Marked by Systemic Oxidative Stress

Assessment of thiol disulfide balance in early‐stage endometrial cancer

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