The relationship between severity of ulcerative colitis and thiol-disulphide homeostasis

Neşeli̇oğlu, Salim; Keske, P. B.; Senat, Almila; Yürekli, Öykü Tayfur; Erdoğan, Serpil; Alışık, Murat; Ergin, Merve; Köseoğlu, Hüseyin; Ersoy, Ömer Faik; Erel, Özcan

doi:10.4149/bll_2018_091

Cited by 11 publications

(47 citation statements)

References 11 publications

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“…This finding may be attributable to low plasma levels of thiol‐containing compounds in celiac disease and decreased intracellular glutathione synthesis in the inflamed intestine 25 . The decrease in the transformation of thiol groups to disulfide bonds may be the reason for the decrease in disulfide bonds 8 . the TDH system may be weakened in celiac disease due to these factors.…”

Section: Discussionmentioning

confidence: 99%

Thiol–disulfide homeostasis in children with celiac disease

Comba

Güreser

Karasartova

et al. 2020

Pediatrics International

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Background Toxic gliadin peptide damages enterocytes in celiac disease by causing oxidative stress. Thiols are organic compounds that defend against oxidative stress. This study aimed to investigate the changes in thiol–disulfide homeostasis in children with celiac disease. Methods The study included patients with celiac disease, children diagnosed with functional gastrointestinal disorders, and healthy children. Patients’ serum native and total thiol–disulfide amounts, disulfide/total thiol percentage ratios, disulfide / native thiol percentage ratios, and native thiol/total thiol percentage ratios were measured. Results The study involved 172 children, of whom 90 (52.3%) were girls. The mean participant age was 8.6 ± 4.2 years. A total of 59 (34.3%) children had celiac disease, 56 (32.6%) had functional gastrointestinal disorders, and 57 (33.1%) were healthy. The total thiol and disulfide levels of patients with celiac disease (305 ± 87 μmol/L and 25 ± 15 μmol/L, respectively) were significantly lower than those of healthy children (349 ± 82 μmol/L and 40 ± 15 μmol/L, respectively) (P = 0.006 and P < 0.001, respectively). Native and total thiol levels (226 ± 85 μmol/L and 279 ± 99 μmol/L, respectively) in patients with celiac disease who consumed a gluten‐containing diet were significantly lower than those of patients who consumed a gluten‐free diet (278 ± 64 μmol/L and 327 ± 69 μmol/L, respectively) (P = 0.017 and P = 0.041, respectively). Conclusions Thiol–disulfide homeostasis, an important antioxidant defense component of the gastrointestinal system, is disrupted in children with celiac disease. A gluten‐free diet helped partially ameliorate this decline.

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Section: Discussionmentioning

confidence: 99%

Thiol–disulfide homeostasis in children with celiac disease

Comba

Güreser

Karasartova

et al. 2020

Pediatrics International

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“…Malnutrition in IBD is common and has a complex, multifactorial background, including altered nutritional intake, malabsorption, medication, excessive gastrointestinal loss, and changed energy requirements. It is considered as one of the extra-intestinal manifestations of IBD and affects particularly pediatric and elderly patients [58]. Albumin has only one redox-active thiol group from cysteine (Cys-34), and due to its high concentration it accounts for 80% (500 µmol/L) thiols in plasma [59].…”

Section: Diagnostic Markers In Ibd (Markers Not Specific For Either Umentioning

confidence: 99%

“…Additional discussed markers or indices can be found in supplementary tables. From among non-enzymatic protein antioxidants ( Supplementary Table S3), thiols have been reportedly more markedly depleted in patients with active than inactive IBD [34] and UC, in which they were inversely correlated with clinical activity of the disease expressed in terms of Truelove-Witts score [58]. The association between thiols and IBD activity has been confirmed by Neubauer et al [73], who also reported negative correlation between their concentrations and CDAI/RI and inflammatory indices as well as lack of difference between active and inactive phases of diseases (Table 3).…”

Section: Progression Markers In Ibd (Markers Not Specific For Either mentioning

confidence: 99%

Oxidative Stress Markers in Inflammatory Bowel Diseases: Systematic Review

et al. 2020

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Precise diagnostic biomarker in inflammatory bowel diseases (IBD) is still missing. We conducted a comprehensive overview of oxidative stress markers (OSMs) as potential diagnostic, differential, progression, and prognostic markers in IBD. A Pubmed, Web of Knowledge, and Scopus search of original articles on OSMs in IBD, published between January 2000 and April 2020, was conducted. Out of 874 articles, 79 eligible studies were identified and used to prepare the interpretative synthesis. Antioxidants followed by lipid peroxidation markers were the most popular and markers of oxidative DNA damage the least popular. There was a disparity in the number of retrieved papers evaluating biomarkers in the adult and pediatric population (n = 6). Of the reviewed OSMs, a promising performance has been reported for serum total antioxidant status as a mucosal healing marker, mucosal 8-OHdG as a progression marker, and for multi-analyte panels of lipid peroxidation products assessed non-invasively in breath as diagnostic and differential markers in the pediatric population. Bilirubin, in turn, was the only validated marker. There is a desperate need for non-invasive biomarkers in IBD which, however, will not be met in the near future by oxidative stress markers as they are promising but mostly at the early research phase of discovery.

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“…It has been shown that increased OS may have a role in the pathogenesis of idiopathic recurrent AP. Many recent studies have reported on thiol levels and thiol/SS homeostasis in patients with chronic hepatitis, ulcerative colitis, and coronary artery disease (14)(15)(16)(17); however, till date, only one study has been conducted on patients with AP (18). To the best of our knowledge, no studies have been conducted with regard to IMA.…”

Section: Introductionmentioning

confidence: 99%

Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis

Uyanıkoğlu

Sabuncu

Yıldız

et al. 2020

Turk J Gastroenterol

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Background/Aims: The aim of this study was to compare the dynamic thiol/disulfide (SS) homeostasis and ischemia-modified albumin (IMA) concentration between healthy subjects and patients with mild acute pancreatitis (AP). Materials and Methods: A total of 28 patients with AP (AP group) and 35 age-and sex-matched healthy individuals (control group) were included in this study. Serum thiols/SS and IMA concentrations were measured and compared between the two groups. Results: The mean serum native thiol (SH) and total thiol (TT) levels were significantly lower in the AP group than in the control group (224.7±80.3 μmol/L vs. 314.66±87.5 μmol/L, p<0.001 and 273.3±76.8 vs. 346.9±79 μmol/L, p<0.001, respectively). SS levels were significantly higher in the AP group than in the control group (24.2±11.1 μmol/L vs. 16.1±9.9 μmol/L, p<0.054). There were no differences in the IMA concentration and the mean IMA/albumin ratio (IMAR) between both the groups. Conclusion: We found that mild AP may affect serum thiol and SS levels, and cause impaired thiol/SS homeostasis.

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The relationship between severity of ulcerative colitis and thiol-disulphide homeostasis

Abstract: The thiol-disulphide homeostasis was weakened in ulcerative colitis. Strong correlations between the activity of the disease and thiol-disulfide homeostasis indicate that homeostasis may play a role in the pathogenesis of the disease (Tab. 3, Fig. 3, Ref. 30).

Cited by 11 publications

References 11 publications

Thiol–disulfide homeostasis in children with celiac disease

Thiol–disulfide homeostasis in children with celiac disease

Oxidative Stress Markers in Inflammatory Bowel Diseases: Systematic Review

Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis

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