Abstract:Background/Aims: The aim of this study was to compare the dynamic thiol/disulfide (SS) homeostasis and ischemia-modified albumin (IMA) concentration between healthy subjects and patients with mild acute pancreatitis (AP). Materials and Methods: A total of 28 patients with AP (AP group) and 35 age-and sex-matched healthy individuals (control group) were included in this study. Serum thiols/SS and IMA concentrations were measured and compared between the two groups. Results: The mean serum native thiol (SH) and … Show more
“…This study demonstrated that sh levels were significantly lower in AP patients than in healthy volunteers. Studies on thiol/disulfide parameters in AP patients have shown similar results to our study (1,6,8). However, Özyazıcı et al studied thiol/disulfide parameters among AP patients and showed that sh levels were significantly lower in AP patients than in control group patients (13).…”
Section: Discussionsupporting
confidence: 86%
“…TDH can easily be measured with an automated assay, described by Erel et al in 2014 (7). Many studies have reported on thiol levels and TDH in different diseases, such as coronary artery disease, ulcerative colitis, and AP (8). This study aimed to evaluate the role of TDH in the differential diagnosis of AP and predict the clinical severity among patients diagnosed with the disease.…”
Objective: Reactive oxygen radicals are generated in the early stages of acute pancreatitis (AP) and are responsible for its progression. Thiol/disulfide homeostasis (TDH) is an important antioxidative mechanism. This study aimed to evaluate the role of TDH in the differential diagnosis of AP and predict its clinical severity.
Methods: Patients admitted to the emergency department due to upper abdominal pain were evaluated. The study consisted of two groups: the AP group and the non-AP group (patients with diagnoses other than AP). The AP group was divided into mild and severe according to Acute physiology and chronic health evaluation II (APACHE-II) scores. TDH was measured with an automated assay from Erel et al. Statistical analyses were done with SPSS 16.0.
Results: The results from 128 cases—58 in the AP group and 70 in the non-AP group—were evaluated. There was no difference in TDH parameters between the AP and non-AP groups. Among the AP subgroups, native thiol (sh) and total thiol (tt) were significantly lower in the severe AP group (sh: 313.9 μmol/L, 239.1 μmol/L; tt: 351.5 μmol/L, 303 μmo/L, respectively, in the mild and severe AP groups, P-value=0.006, P-value=0.013).
Conclusion: TDH parameters change because of inflammatory processes in AP. Since this change does not occur for any specific reason, using TDH parameters for differential diagnosis of AP in patients with upper abdominal pain is not appropriate. However, in patients already diagnosed with AP, native and total thiol levels might be helpful in the prediction of clinical severity with a limited role.
“…This study demonstrated that sh levels were significantly lower in AP patients than in healthy volunteers. Studies on thiol/disulfide parameters in AP patients have shown similar results to our study (1,6,8). However, Özyazıcı et al studied thiol/disulfide parameters among AP patients and showed that sh levels were significantly lower in AP patients than in control group patients (13).…”
Section: Discussionsupporting
confidence: 86%
“…TDH can easily be measured with an automated assay, described by Erel et al in 2014 (7). Many studies have reported on thiol levels and TDH in different diseases, such as coronary artery disease, ulcerative colitis, and AP (8). This study aimed to evaluate the role of TDH in the differential diagnosis of AP and predict the clinical severity among patients diagnosed with the disease.…”
Objective: Reactive oxygen radicals are generated in the early stages of acute pancreatitis (AP) and are responsible for its progression. Thiol/disulfide homeostasis (TDH) is an important antioxidative mechanism. This study aimed to evaluate the role of TDH in the differential diagnosis of AP and predict its clinical severity.
Methods: Patients admitted to the emergency department due to upper abdominal pain were evaluated. The study consisted of two groups: the AP group and the non-AP group (patients with diagnoses other than AP). The AP group was divided into mild and severe according to Acute physiology and chronic health evaluation II (APACHE-II) scores. TDH was measured with an automated assay from Erel et al. Statistical analyses were done with SPSS 16.0.
Results: The results from 128 cases—58 in the AP group and 70 in the non-AP group—were evaluated. There was no difference in TDH parameters between the AP and non-AP groups. Among the AP subgroups, native thiol (sh) and total thiol (tt) were significantly lower in the severe AP group (sh: 313.9 μmol/L, 239.1 μmol/L; tt: 351.5 μmol/L, 303 μmo/L, respectively, in the mild and severe AP groups, P-value=0.006, P-value=0.013).
Conclusion: TDH parameters change because of inflammatory processes in AP. Since this change does not occur for any specific reason, using TDH parameters for differential diagnosis of AP in patients with upper abdominal pain is not appropriate. However, in patients already diagnosed with AP, native and total thiol levels might be helpful in the prediction of clinical severity with a limited role.
“…Therefore, deterioration of oxidative balance could cause abnormalities at structural and functional levels. 6,[9][10][11][12][13][14][15] In the literature, change in the thiol/disulphide homeostasis has been shown in diabetes mellitus, cardiovascular disorders, malignancy, rheumatoid arthritis, adenoid hypertrophy, acute pancreatitis, otitis media, β -thalassemia major, placenta percreta, inflammatory bowel diseases, rosacea and chronic kidney failure. [9][10][11][12][13][14][15] Another study by Atasever et al also investigated the thiol/disulphide homeostasis in ovarian torsion.…”
Ovarian torsion is one of the reasons of acute abdomen requiring immediate surgical intervention. There is not any reliable method for its diagnosis. Delay in treatment may result in loss of ovary. In this study, the purpose is to evaluate efficiency of thioldisulphide homeostasis in early diagnosis of ovarian torsion in experimental rat model and in its follow-up care with biochemical and histopathological findings. Material and Methods: In the study, 24 Albino Wistar female rats were divided into three groups. The first group was the sham group. The second group was the torsion group. The last group was the torsion-detorsion group. Histopathological evaluation was carried out in ovaries in all groups, and values of thiol/disulphide homeostasis were measured in serum samples biochemically. Results: Values of native thiol and total thiol were lower in the torsion-detorsion group compared to the other groups. However, there was no significant difference between of native thiol and total thiol levels in the sham and torsion groups. Interestingly, the index of native thiol/total thiol was relatively low in the torsion and torsion-detorsion groups compared to the sham group. However, this decrease was not significant. Conclusion: These results suggest that native thiol/total thiol values may not be useful for early diagnosis of ovarian torsion but it may be used for follow-up care after detorsion
“…In order to calculate the sample size required by the study, a G*Power analysis was performed based on the results of a previous study 11 . Taking the target alpha (α) and 1 − beta (β) error levels as 0.05 and 0.95, respectively, it was determined a minimum of 34 participants were required for each group (68 in total) to achieve 95% power.…”
AimWe aim to compare the maternal serum thiol and ischemia‐modified albumin (IMA) levels between pregnant women with placenta previa and those with uncomplicated pregnancies and to determine whether changes in these levels were useful in predicting cases of abnormally invasive placenta (AIP).MethodsFifty‐five pregnant women diagnosed with placenta previa according to the diagnostic criteria (case group) were compared to 100 women with uncomplicated pregnancies of similar demographic characteristics (control group). The patients with placenta previa were further divided into two subgroups: AIP (n = 20) and placenta previa without invasion (n = 35). The maternal serum native thiol, total thiol, disulfide, and IMA levels of the groups were evaluated.ResultsThe native thiol, total thiol, and IMA values were significantly lower in the case group than in the control group (p < 0.001). The disulfide values were similar between the study and control groups (p = 0.488). When the AIP and placenta previa without invasion groups were compared, the levels of native thiol, total thiol, disulfide, and IMA were similar (p > 0.05).ConclusionsMaternal serum thiol and IMA levels were lower in placenta previa cases compared to the control group. However, these parameters were not useful in predicting AIP cases.
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