Drug loaded thermoresponsive and cytocompatible chitosan based hydrogel as a potential wound dressing

Radhakumary, C.; Antonty, Molly; Sreenivasan, K.

doi:10.1016/j.carbpol.2010.08.042

Cited by 149 publications

(68 citation statements)

References 32 publications

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“…This developed material was cytocompatible toward human skin fibroblast cells (Pang et al, 2008). Interestingly, a thermo-sensitive film was prepared by combining thiolated chitosan, poly(N-isopropyl acrylamide) and ciprofloxacin, so that by decreasing the temperature, the film can easily be removed from wound (Radhakumary et al, 2011).…”

Section: Chitosan Based Composite Scaffolds In Wound Healingsmentioning

confidence: 99%

“…The thiolated chitosan with poly(N-isopropyl acrylamide) loaded with ciprofloxacin was cytocompatible and found to modulate the release of the incorporated ciprofloxacin in a sustained fashion reflecting its suitability to protect a wound for a prolonged period. The combination of thiolated chitosan with poly(N-isopropyl acrylamide) and ciprofloxacin showed antibacterial properties to the virulent bacteria E. coli supporting its potential as a wound dressing (Radhakumary et al, 2011).…”

Section: Chitosan Based Drug Loaded Scaffolds In Wound Healingsmentioning

confidence: 99%

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Chitosan Based Scaffolds and Their Applications in Wound Healing

Ahmed

Ikram

2016

Achievements in the Life Sciences

349

204

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Section: Chitosan Based Composite Scaffolds In Wound Healingsmentioning

confidence: 99%

Section: Chitosan Based Drug Loaded Scaffolds In Wound Healingsmentioning

confidence: 99%

Chitosan Based Scaffolds and Their Applications in Wound Healing

Ahmed

Ikram

2016

Achievements in the Life Sciences

349

204

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“…The drug release was in controlled and continuous so it protects wound for a long time. They exhibited antibacterial activity against E. coli [24].…”

Section: Chitosan With Drug Formulations In Haemostatic and Wound Heamentioning

confidence: 99%

Chitosan: A Promising Substrate for Regenerative Medicine in Drug Formulation

Kashyap

Archana

Semwal³

et al. 2015

Springer Series on Polymer and Composite Materials

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Chitosan plays a most important role in the regenerative medication for wound healing. The adhesive nature of chitosan, with their antifungal and bactericidal character, and their permeability to oxygen, is a very important property associated with the treatment of wounds. Different derivatives and combination of chitosan have been reported for this purpose in the form of hydrogels, fibers, membranes, scaffolds and sponges. The purpose of the chapter is to have a closer look in the work done directly by different researchers on the chitosan formulation with potential medicinal applications to provide a better understanding of its usability in regenerative medicine.

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“…Special emphasis is placed on the comprehensive analytical characterization of all chitosan thiomers in light of reliable SAR trends for drug design guidelines. Among the target compounds of this study, antibacterial activity tests have only been performed before for chitosan-TGA (Geisberger et al, 2013), which was particularly effective against Streptococcus sobrinus, and for chitosan-MPA (Radhakumary, Antonty, & Sreenivasan, 2011) that was combined with poly(N-isopropyl acrylamide) and ciprofloxacin to constitute films, wherein the biopolymers contributed no additional antimicrobial effect. To the best of our knowledge, all other members of the series are novel.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and screening of N-acyl thiolated chitosans for antibacterial applications

Croce

Conti

Maake

et al. 2016

Carbohydrate Polymers

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Low-molecular weight chitosan-thioglycolic acid has shown significant antibacterial properties against different microorganisms. In order to explore the potential and structure-activity relationships of newly synthesized alkyl thiomers, chitosan has been functionalized with a series of thio-acids with increasing alkyl chain length. All thiomers were characterized with special emphasis on the determination of their degree of deacetylation and substitution, as well as on their molecular weight and amount of thiol groups. The pre-screened chitosan-thiomers were further investigated with plate counting on Pseudomonas aeruginosa, Streptococcus sobrinus and Streptococcus mutans. Furthermore, LIVE/DEAD assays supported the efficiency of chitosan-thiomers against the above microorganisms. All fully characterized chitosan-thiomers showed comparable or enhanced antimicrobial activity compared to pristine chitosan. Our comprehensive approach paves the way to detailed explorations of much sought-after structure activity relationships in the complex chitosan parameter room, starting from correlations between alkyl chain length and antimicrobial activity.

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Drug loaded thermoresponsive and cytocompatible chitosan based hydrogel as a potential wound dressing

Cited by 149 publications

References 32 publications

Chitosan Based Scaffolds and Their Applications in Wound Healing

Chitosan Based Scaffolds and Their Applications in Wound Healing

Chitosan: A Promising Substrate for Regenerative Medicine in Drug Formulation

Synthesis and screening of N-acyl thiolated chitosans for antibacterial applications

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