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The feed additives are the essential compound of the fish diet. The use of feed additives in the animal's diet is a vital role to rising growth and immunity of the aquatic animals. Feed additives are substances which are added in trace amounts in fish diet it is also act as ingredients improver or preserve it. The major feed additives are act as preservatives, binders, feeding stimulants, and food colorants etc. In favor of growing aquaculture in a supportable fashion, the use of additives must be in correct amount. The requirement of additives are depends on species and their availability. Some authors exposed that the feed additive to have antimicrobial, anti-oxidative, growth promoting ability as well as it is improve the fish immune system.

Chitosan plays a most important role in the regenerative medication for wound healing. The adhesive nature of chitosan, with their antifungal and bactericidal character, and their permeability to oxygen, is a very important property associated with the treatment of wounds. Different derivatives and combination of chitosan have been reported for this purpose in the form of hydrogels, fibers, membranes, scaffolds and sponges. The purpose of the chapter is to have a closer look in the work done directly by different researchers on the chitosan formulation with potential medicinal applications to provide a better understanding of its usability in regenerative medicine.

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OBJECTIVE: In recent years, excipient development has become major area of research in pharmaceutical drug delivery because it influences the formulation development and drug delivery process in various ways. In modern pharmaceutical science biopolymers are choice of research as excipient because of their low toxicity, biocompatibility, biodegrability, stability and renewable nature. Chitosan, a biodegradable polysaccharide derived from chitin and found widely in nature, possesses properties making it particularly suitable as a carrier, including its high viscosity, charge distribution and release mechanisms. Our present research work includes preparation and characterization of chitosan-moxifloxacin conjugates designed in accordance with specific biomedical requirements. METHODS:In this research work chitosan based chitosan-moxifloxacin conjugates have been successfully formulated by using distilled water and glacial acetic acid mixture and the film was made by solution casting method. Formulated films were characterized by various analytical methods such as UV, IR and DSC as well as biological methods. RESULTS:The antibacterial activity of chitosan-moxifloxacin conjugates was tested against various microorganisms viz, gram positive bacteria's Streptococcus pneumoniae and Staphylococcus aureus and the results indicated that the antibacterial activity of chitosan-moxifloxacin conjugates was several time greater than that of parent drug moxifloxacin. This may be due to the favorable pharmacokinetics, pharmacodynamics, excellent bacterial susceptibility and good stability of the drug conjugates.CONCLUSION: This proposed combination may result in the enhancement of the separate activities of chitosan and moxifloxacin.

Chitin is the most important natural polysaccharide after cellulose, found in crustaceous shell or in cell walls of fungi. Chitosan, one of the natural multifunctional polymers, due to its unique and versatile biological properties is regarded as a useful compound in medical and pharmaceutical technology. In recent times chitosan has been far and wide used as a popular formulation excipient due to its inimitable characteristics in the field of pharmaceutical sciences as binding, disintegrating, stabilizing, suspending, tablet coating, and film forming material. Recently, considerable research effort has been made in order to develop safe and efficient chitosan products. Chitosan has been comprehensively investigated for its suitability for its controlled release characteristics in various studies. Oral delivery of genes and peptides by means of different formulations based on chitosan is also investigated in various examinations by the capability of its absorption and penetration enhancing properties. It is possessing tremendous mucoadhesive and inherent anti-microbial properties, so that it can be used as a carrier for novel drug delivery. In addition to the above mentioned reasons, tailoring the controlled release and to improve the therapeutic efficacy of the low molecular weight drug compounds can also be achieved by this polymer and moreover in combination with various polymers is feasible due its compatibility i.e. low chemical reactivity. This brief editorial epitomizes the potential applications of chitosan in novel drug delivery systems.

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