Chitosan: A Promising Substrate for Regenerative Medicine in Drug Formulation

Kashyap, Madhu; Archana, D.; Semwal, Alok; Dutta, Joydeep; Dutta, Parikshit

doi:10.1007/978-81-322-2511-9_10

Cited by 7 publications

(3 citation statements)

References 78 publications

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“…Chitosan-based drug carriers are a promising method for delivering therapeutic medicament doses into periodontal tissues. Table 4 shows advantages and disadvantages of different chitosan formulations Chitosan-based fibers, films, sponges, and injectable systems such as micro particles, nanoparticles, and gels are among the delivering modalities developed for sustained medicine release into the periodontal tissues [ 72 ]. Figure 4 shows different formulations of chitosan.…”

Section: Chitosan-derived Drug Delivery Systemsmentioning

confidence: 99%

Drug-Loaded Chitosan Scaffolds for Periodontal Tissue Regeneration

et al. 2022

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Chitosan is a natural anionic polysaccharide with a changeable architecture and an abundance of functional groups; in addition, it can be converted into various shapes and sizes, making it appropriate for a variety of applications. This article examined and summarized current developments in chitosan-based materials, with a focus on the modification of chitosan, and presented an abundance of information about the fabrication and use of chitosan-derived products in periodontal regeneration. Numerous preparation and modification techniques for enhancing chitosan performance, as well as the uses of chitosan and its metabolites, were reviewed critically and discussed in depth in this study. Chitosan-based products may be formed into different shapes and sizes, considering fibers, nanostructures, gels, membranes, and hydrogels. Various drug-loaded chitosan devices were discussed regarding periodontal regeneration.

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Section: Chitosan-derived Drug Delivery Systemsmentioning

confidence: 99%

Drug-Loaded Chitosan Scaffolds for Periodontal Tissue Regeneration

et al. 2022

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“…[181] The main requisites to build these systems are biodegradability and biocompatibility, which typically are provided by natural polymers such as CHI. [182,183]…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Chitosan nanocomposites based on distinct inorganic fillers for biomedical applications

Moura

Mano

Paiva

et al. 2016

Science and Technology of Advanced Materials

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Chitosan (CHI), a biocompatible and biodegradable polysaccharide with the ability to provide a non-protein matrix for tissue growth, is considered to be an ideal material in the biomedical field. However, the lack of good mechanical properties limits its applications. In order to overcome this drawback, CHI has been combined with different polymers and fillers, leading to a variety of chitosan-based nanocomposites. The extensive research on CHI nanocomposites as well as their main biomedical applications are reviewed in this paper. An overview of the different fillers and assembly techniques available to produce CHI nanocomposites is presented. Finally, the properties of such nanocomposites are discussed with particular focus on bone regeneration, drug delivery, wound healing and biosensing applications.

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“…It also exhibits some antibacterial properties [7]. This antimicrobial ability makes chitosan a suitable candidate for implant coatings, wound dressing, and drug delivery applications, but chitosan has a major flaw which is its inherent mechanical weakness [8,9,10]. Many approaches, such as the addition of various polymers, [11,12] carbon nanotubes, [13,14] or clay nanoparticles [15,16], have been studied as a means to improve chitosan’s mechanical properties, and these additives increased the roughness of the scaffold which enhaced cell attachment, proliferation and differentiation [17,18,19].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Halloysite Addition on the Material Properties of Chitosan–Halloysite Hydrogel Composites

Luo

Mills

2019

Gels

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Chitosan-based hydrogels are being widely used in biomedical applications due to their eco-friendly, biodegradable, and biocompatible properties, and their ability to mimic the extracellular matrix of many tissues. However, the application of chitosan hydrogels has been limited due to their inherent mechanical weakness. Halloysite nanotubes (HNTs) are naturally occurring aluminosilicate clay minerals and are widely used as a bulk filler to improve the performance characteristics of many polymeric materials. HNTs have also been shown to be a viable nanocontainer able to provide the sustained release of antibiotics, chemicals, and growth factors. This study’s objective was to develop a stable drug delivery chitosan/HNT nanocomposite hydrogel that is biocompatible, biodegradable, and provides sustained drug release. In this study, chitosan/HNTs hydrogels containing undoped or gentamicin-doped HNTs were combined in different wt./wt. ratios and cross-linked with tripolyphosphate. The effects of chitosan and HNTs concentration and combination ratios on the hydrogel surface morphology, degradability, and mechanical properties, as well as its drug release capability, were analyzed. The results clearly showed that the addition of HNTs improved chitosan mechanical properties, but only within a narrow range. The nanocomposite hydrogels provided a sustained pattern of drug release and inhibited bacterial growth, and the live/dead assay showed excellent cytocompatibility.

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Chitosan: A Promising Substrate for Regenerative Medicine in Drug Formulation

Cited by 7 publications

References 78 publications

Drug-Loaded Chitosan Scaffolds for Periodontal Tissue Regeneration

Drug-Loaded Chitosan Scaffolds for Periodontal Tissue Regeneration

Chitosan nanocomposites based on distinct inorganic fillers for biomedical applications

The Effect of Halloysite Addition on the Material Properties of Chitosan–Halloysite Hydrogel Composites

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