Diabetes Mellitus Type 1 in Adolescents: Impact of Vitamin D Status

Abstract

The aim: To evaluate the effect of vitamin D deficiency or insufficiency on the compensation of the disease in adolescents with diabetes mellitus type 1. Materials and methods: 124 patients were examined, among them: 33 from the control group, 91 adolescents with type 1 diabetes mellitus. All patients were between 10-18 years old and were residents of the Podillya region of Ukraine. Results: According to the results of the study Vitamin D levels in adolescents with type 1 diabetes mellitus are significantly lower, comparing with healthy adolescents of the same age group. Vitamin D levels among boys with type 1 diabetes mellitus were significantly lower comparing to girls of the same group. The boys of the control group had significantly higher levels of vitamin D in the blood comparing to boys with type 1 diabetes mellitus, p <0.001. Conclusions: The majority of adolescents aged 13-18 years with type 1 diabetes mellitus have vitamin D deficiency or insufficiency regardless of the state of glycemic control of the disease.

Proportion of vitamin D deficiency in children/adolescents with type 1 diabetes: A systematic review and meta-analysis

“…The main characteristics of the 45 included studies are shown in Table 1. In accordance with the recommended NOS and AHRQ criteria, only studies of acceptable quality were included in the present meta-analysis; eight studies received 9 stars [51,53,[56][57][58]62,63,66], ten studies received 8 stars [43,[48][49][50]52,54,55,[59][60][61], ve studies received 7 stars [42,[44][45][46][47] and one study received 6 stars [41]. When using the quality assessment criteria from the AHRQ, three studies received a score of 11 [24,29,65], ten received a score of 10 [22,25,28,29,31,33,34,36,39,40], three received a score of 9 [23,32,35], one received a score of 8 [27], one received a score of 7 [37] and two received a score of 5 [26,38], the quality assessment are shown in Appendix S2.…”

Effectiveness of vitamin D intake in adolescents with type 1 diabetes mellitus

“…Дані щодо забезпеченості вітаміном D серед дитячого населення України на сьогоднішній день є недостатньо вивченими. Однак, відомо, що ступінь забезпеченості вітаміном D серед підлітків, які хворіють на ЦД 1 типу є незадовільною [4].…”

Gesundheit von Säuglingen und Kindern: Auf den Biofaktorenstatus achten

“…Vitamin D wirkt immunmodulatorisch durch den Vitamin-D-Rezeptor, der auf Pankreas-und Immunzellen vorhanden ist [18]. Es ist ebenfalls gut dokumentiert, dass Kinder und Jugendliche mit einem Typ-1-Diabetes häufiger unter einem Vitamin-D 3 -Mangel leiden [19,20] -und dass sich eine entsprechende Supplementation positiv auswirken kann [21].…”