Developments in polymeric devices for oral insulin delivery

Babu, V. Ramesh; Patel, Paresh N.; Mundargi, Raghavendra C.; Rangaswamy, Vidhya; Aminabhavi, Tejraj M.

doi:10.1517/17425247.5.4.403

Cited by 63 publications

(34 citation statements)

References 63 publications

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“…In line with a previous in vitro study and comparable to optimal drug delivery systems using other techniques, the binding efficiency and the release kinetics of the MCM used in the present study were as expected (Yu et al, 2014;Babu et al, 2008;Carrasquillo et al, 2001). The incorporation of growth factors is a crucial factor for delivery strategies.…”

Section: Orth Et Al Bmp-2-coated MCM and Bone Repairsupporting

confidence: 92%

BMP-2-coated mineral coated microparticles improve bone repair in atrophic non-unions

Orth

Kruse²,

Braun³

et al. 2017

eCM

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Atrophic non-unions are a major clinical problem. Mineral coated microparticles (MCM) are electrolyte-coated hydroxyapatite particles that have been shown in vitro to bind growth factors electrostatically and enable a tuneable sustained release. Herein, we studied whether MCM can be used in vivo to apply Bone Morphogenetic Protein-2 (BMP-2) to improve bone repair of atrophic non-unions. For this purpose, atrophic non-unions were induced in femurs of CD-1 mice (n = 48). Animals either received BMP-2-coated MCM (MCM + BMP; n = 16), uncoated MCM (MCM; n = 16) or no MCM (NONE; n = 16). Bone healing was evaluated 2 and 10 weeks postoperatively by micro-computed tomographic (µCT), biomechanical, histomorphometric and immunohistochemical analyses. µCT revealed more bone volume with more highly mineralised bone in MCM + BMP femurs. Femurs of MCM + BMP animals showed a significantly higher bending stiffness compared to other groups. Histomorphometry further demonstrated that the callus of MCM + BMP femurs was larger and contained more bone and less fibrous tissue. After 10 weeks, 7 of 8 MCM + BMP femurs presented with complete osseous bridging, whereas NONE femurs exhibited a non-union rate of 100 %. Of interest, immunohistochemistry could not detect macrophages within the callus, indicating a good biocompatibility of MCM. In conclusion, the local application of BMP-2-coated MCM improved bone healing in a challenging murine non-union model and, thus, should be of clinical interest in the treatment of non-unions.

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Section: Orth Et Al Bmp-2-coated MCM and Bone Repairsupporting

confidence: 92%

BMP-2-coated mineral coated microparticles improve bone repair in atrophic non-unions

Orth

Kruse²,

Braun³

et al. 2017

eCM

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“…Moreover several scientific investigations were carried out by researchers on pH responsive polymer-based devices like hydrogels (Kiran et al, 2013), microspheres (Raghavendra et al, 2011b) etc. for delivery of insulin orally (Babu et al, 2008). However, no such report has been documented on PMV-coated MSN for oral delivery of insulin.…”

Section: Introductionmentioning

confidence: 99%

pH responsive cylindrical MSN for oral delivery of insulin-design, fabrication and evaluation

Guha¹,

Biswas²,

Bhattacharjee

et al. 2016

Drug Delivery

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Objective: The objective of the present study was to develop novel PMV [poly (methacrylic acidco-vinyl triethoxylsilane)]-coated mesoporous silica nanoparticles (MSN) with improved hypoglycemic effect for oral insulin (INS) delivery. Methods: MSN was synthesized under acidic condition using Pluronic Õ P 123 and Tetra ethoxy orthosilane. Surfactant was removed by calcination. Calcined MSN was coated with pH sensitive polymer PMV. Cytotoxicity of this coated MSN was evaluated by MTT assay using CHO-K1 cell line. Different MSN samples were characterized with BET surface area analyzer, FESEM, TEM, FT-IR, XRD, TG-DTA. In vivo study was performed using male rats. Pharmacokinetic study was conducted using HPLC. Results and discussion: Highest surface area (304.3921 m 2 /g) was observed in case of calcined sample. Adsorption pore width of final coated sample was highest (64.7844 nm) compared with others. No noticeable cytotoxicity was observed for this coated support. The entrapment efficiency of insulin was found to be 39.39%. In vitro studies were done at different pH using Franz-diffusion cell. Results showed significant release at pH 7.4. Cumulative drug release over a period of 6 h was more than 48% at this systemic pH. Effect of this MSN-PMV-INS on blood glucose level was retained for 16 h. This novel formulation has shown 73.10% relative bioavailability of insulin. Conclusion: A novel-coated mesoporous silica support was successfully developed for delivery of insulin through oral route.

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“…Evaluation of pharmacological activities and drug delivery methods of conventional medications in long term diabetes management is still under consideration. For example, administration of Insulin via oral route along with the efficacy and challenges of this method have been studied worldwide to increase patient compliance [12]. Simultaneously, search for novel bioactive molecules against type ІІ diabetes are also ongoing in both synthetic and natural product chemistry.…”

Section: Introductionmentioning

confidence: 99%

In vitro and In vivo Studies of Drug-Drug Interaction between Metformin and Cefepime

Ferdous¹,

Sultan²,

Bashar³

et al. 2015

Pharm Anal Acta

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A diabetic individual gradually becomes more prone to infections and can be prescribed Metformin concurrently with a broad spectrum antibiotic like Cefepime. Our research examines the possibility of drug-drug interaction between Metformin and Cefepime in a number of in vitro and in vivo parameters. The in vitro tests including Differential Scanning Calorimeter, Scanning Electron Microscope and Fourier Transform Infra Red analysis were found to reveal visible changes in melting points, morphological structures and rearrangement of functional groups due to the interaction. The disc diffusion method was used to compare the antimicrobial properties of all the test samples and the antimicrobial potential of Cefepime was found to be suppressed moderately after in vitro interaction with Metformin. The alteration of the in vivo antidiabetic activity of Metformin was evaluated in streptozotocin-induced Long-Evans Rats, and the anti-hyperglycemic effect of Metformin was detected to decrease significantly in the resulting product of this interaction.

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Developments in polymeric devices for oral insulin delivery

Cited by 63 publications

References 63 publications

BMP-2-coated mineral coated microparticles improve bone repair in atrophic non-unions

BMP-2-coated mineral coated microparticles improve bone repair in atrophic non-unions

pH responsive cylindrical MSN for oral delivery of insulin-design, fabrication and evaluation

In vitro and In vivo Studies of Drug-Drug Interaction between Metformin and Cefepime

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