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Over the past several years, treatment of infectious diseases and immunisation has undergone a revolutionary shift. With the advancement of biotechnology and genetic engineering, not only a large number of disease-specific biological have been developed, but also emphasis has been made to effectively deliver these biologicals. Niosomes are vesicles composed of non-ionic surfactants, which are biodegradable, relatively nontoxic, more stable and inexpensive, an alternative to liposomes. This article reviews the current deepening and widening of interest of niosomes in many scientific disciplines and, particularly its application in medicine. This article also presents an overview of the techniques of preparation of niosome, types of niosomes, characterisation and their applications.

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With the recent advancement in the field of ocular therapy, drug delivery approaches have been elevated to a new concept in terms of nonionic surfactant vesicles (NSVs), that is, the ability to deliver the therapeutic agent to a patient in a staggered profile. However the major drawbacks of the conventional drug delivery system like lacking of permeability through ocular barrier and poor bioavailability of water soluble drugs have been overcome by the emergence of NSVs. The drug loaded NSVs (DNSVs) can be fabricated by simple and cost-effective techniques with improved physical stability and enhance bioavailability without blurring the vision. The increasing research interest surrounding this delivery system has widened the areas of pharmaceutics in particular with many more subdisciplines expected to coexist in the near future. This review gives a comprehensive emphasis on NSVs considerations, formulation approaches, physicochemical properties, fabrication techniques, and therapeutic significances of NSVs in the field of ocular delivery and also addresses the future development of modified NSVs.

The paper attempts to enhance the control of convective transport phenomena in magnetothermal devices applying a technique of multibanded magnetic field. For this demonstration, a typical cavity-like thermal system is considered involving linear heating, porous substance, hybrid nanofluid, and magnetic field. Four identical bands of magnetic fields are applied horizontally with uniform inactive zones between the bands. The transport equations of the coupled multiphysics evolving from the thermal buoyancy (due to linear heating at one sidewall and isothermal cooling at the opposite sidewall), filled porous medium, spatially intermittently active magnetic fields, and the engineered working fluid of Cu–Al2O3/water hybrid nanofluid are solved by an indigenously developed computing code. The study is conducted using the pertinent dimensionless parameters for the following ranges: Darcy–Rayleigh number (Ram = 1–104), Darcy number (Da = 10−5 − 10−1), Hartmann number (Ha = 0–70), and concentration of hybrid nanoparticles ϕ (= 0–2%). The convective phenomena are analyzed using the heatlines (for heat transport), streamlines (flow pattern), isotherms (static temperature), and the average Nusselt number (for heat transfer). The outcomes of this technique of multibanded magnetic field are rigorously compared with other established application methods of magnetic fields. It establishes different local behaviors along with an improved heat transfer. Heatline visualization reveals the definite portraits of heat flow paths depending upon parametric values. Furthermore, the presence of linear heating is in particular treated to explore the insight of linear heating (that featuring multiple heating and cooling zones along with the linear heater), utilizing the local Nusselt number and heatlines. One of the important advantages of this new technique is it is more energy-efficient particularly for the square or shallow cavity. The multibanded magnetic field shows a promising technique for the control of convective transport phenomena involving coupled multiphysics used during sophisticated applications (such as materials processing, biomedical applications, etc.).