Recent advancement of gelatin nanoparticles in drug and vaccine delivery

Potential doxorubicin delivery system based on magnetic gelatin microspheres crosslinked with sugars

“…The Type A gelatin (pH 3.8-6.0; iso-electric point 6-8) is obtained from acidic hydrolysis of pork skin and the Type B gelatin (pH 5.0-7.4; isoelectric point 4.7-5.3) is obtained from basic hydrolysis of bones and animal skin [1] . Attributable to the excellent biocompatibility and biodegradability [2,3] , gelatin has been widely used in biomedical materials for controlled drug release. In this application, can be found gelatin in different forms: films [4][5][6] , disks [7] , hydrogels [8,9] , sponges [10] and frequently microspheres [7,9,[11][12][13][14] .…”

“…Thus, gelatin hydrogels can be prepared as three-dimensional hydrophilic networks that are able to release drugs at the controlled rates. Such networks can be physical as those obtained by gelatin mixed with other polymers such as sodium carboxymethyl cellulose [17] , hydroxyethyl cellulose [18] and carboxymethyl guar gum [19] to form interpenetrating polymer networks (IPNs) or chemical as those obtained by using chemical crosslinking agents [2] . The chemical crosslinking agents are bifunctional or polyfunctional compounds that act by binding to carboxylic or amino groups of adjacent molecules of gelatin.…”

Gelatin as a Chlorhexidine Digluconate Immobilizing Agent

“…Thus, the failure to encapsulate chlorhexidine [10,11] to the polymer matrix of interest via emulsion due to incompatibility between both components is a stimulus to the development of a powder formulation so that the drug could be incorporated into the polymer matrix and thus, a more efficient controlled release system could be developed for use in the oral cavity. To achieve this goal, gelatin, a natural polymer produced from collagen hydrolysates or the polysaccharide fraction of seaweed was used as a Chlorhexidine immobilizer [12][13][14][15][16]. Differently from other studies, which were focused on the use gelatin as the primary polymer matrix, the present study aims to obtain a powder of chlorhexidine in a fast and cheap way.…”

Efeito Da Adição De Gelatina Em Emulsões Preparadas Com Quitosana Para Encapsular Concentrados De Ácidos Graxos Insaturados De Óleo De Pescado

“…Seu uso em alimentos se destaca devido ao seu alto teor de aminoácidos como a glicina, prolina e alanina, agregando valor nutritivo ao alimento por ser totalmente digerível. A adição de gelatina na formação de emulsões pode melhorar fluidez de emulsões, e prevenir coalescência e separação de fases em diferentes sistemas de emulsão em que estão dispersos óleos e glóbulos de gorduras (Duconseille et al, 2015;Sahoo et al, 2015). Por apresentar as vantagens mencionadas, o presente trabalho teve como objetivo avaliar a viabilidade da substituição parcial de quitosana por gelatina na formação de emulsões estáveis para encapsular concentrados de ácidos graxos insaturados obtidos de óleo de vísceras de carpa comum.…”