Niosome: A future of targeted drug delivery systems

Kazi, Karim Masud; Mandal, Asim Sattwa; Biswas, Nirmalendu; Guha, Arun K.; Chatterjee, Sugata; Behera, Mamata; Kuotsu, Ketousetuo

doi:10.4103/0110-5558.76435

Cited by 412 publications

(83 citation statements)

References 21 publications

(40 reference statements)

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“…They can also be modified with respect to their fatty acid and head group composition, and surface alterations to modulate drug release and target affinity. Some of the issues associated with liposomes such as degradation by hydrolysis, oxidation, sedimentation, aggregation, or fusion during storage are being addressed with the development of niosomes [18] and proniosomes [19,20], however further testing is needed to fully establish safety and efficacy.…”

Section: Introductionmentioning

confidence: 99%

Branched amphiphilic peptide capsules: Cellular uptake and retention of encapsulated solutes

Sukthankar

Avila

Whitaker

et al. 2014

Biochimica et Biophysica Acta (BBA) - Biomembranes

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Branched amphiphilic peptide capsules (BAPCs) are peptide nanospheres comprised of equimolar proportions of two branched peptide sequences bis(FLIVI)-K-KKKK and bis(FLIVIGSII)-K-KKKK that self-assemble to form bi-layer delimited capsules. In two recent publications we described the lipid analogous characteristics of our BAPCs, examined their initial assembly, mode of fusion, solute encapsulation, and resizing and delineated their capability to be maintained at a specific size by storing them at 4 °C. In this report we describe the stability, size limitations of encapsulation, cellular localization, retention and, bio-distribution of the BAPCs in vivo. The ability of our constructs to retain alpha particle emitting radionuclides without any apparent leakage and their persistence in the peri-nuclear region of the cell for extended periods of time, coupled with their ease of preparation and potential tune-ability, makes them attractive as biocompatible carriers for targeted cancer therapy using particle emitting radioisotopes. This article is part of a Special Issue entitled: Interfacially active peptides and proteins.

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Section: Introductionmentioning

confidence: 99%

Branched amphiphilic peptide capsules: Cellular uptake and retention of encapsulated solutes

Sukthankar

Avila

Whitaker

et al. 2014

Biochimica et Biophysica Acta (BBA) - Biomembranes

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“…In many ways Niosomes are liposome analogs and are prepared much like liposomes through non-spontaneous processes involving the input of energy in the form of heat, ultrasound, physical agitation, application of pressure or a combination thereof. 153 Consequently, just like liposomes, most NSV preparation methods involve some hydration of the non-ionic surfactant at an elevated temperature followed by an optional size reduction to obtain the colloidal suspension. 154 Negatively charged molecules such as dicetyl phosphate (DCP) and phosphatidic acid, or positively charged molecules such as cetylpyridinium chloride and stearylamine (SA) can be added (2.5 – 5 mol%) to prevent aggregation and stabilize the niosomal bilayer.…”

Section: Structures Of Self-assembling Nanoparticlesmentioning

confidence: 99%

“…154 Negatively charged molecules such as dicetyl phosphate (DCP) and phosphatidic acid, or positively charged molecules such as cetylpyridinium chloride and stearylamine (SA) can be added (2.5 – 5 mol%) to prevent aggregation and stabilize the niosomal bilayer. 152,153 …”

Section: Structures Of Self-assembling Nanoparticlesmentioning

confidence: 99%

A review of solute encapsulating nanoparticles used as delivery systems with emphasis on branched amphipathic peptide capsules

Barros

Whitaker

Sukthankar

et al. 2016

Archives of Biochemistry and Biophysics

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Various strategies are being developed to improve delivery and increase the biological half-lives of pharmacological agents. To address these issues, drug delivery technologies rely on different nano-sized molecules including: lipid vesicles, viral capsids and nano-particles. Peptides are a constituent of many of these nanomaterials and overcome some limitations associated with lipid-based or viral delivery systems, such as tune-ability, stability, specificity, inflammation, and antigenicity. This review focuses on the evolution of bio-based drug delivery nanomaterials that self-assemble forming vesicles/capsules. While lipid vesicles are preeminent among the structures; peptide-based constructs are emerging, in particular peptide bilayer delimited capsules. The novel biomaterial— Branched Amphiphilic Peptide Capsules (BAPCs) display many desirable properties. These nano-spheres are comprised of two branched peptides— bis(FLIVI)-K-KKKK and bis(FLIVIGSII)-K-KKKK, designed to mimic diacyl-phosphoglycerides in molecular architecture. They undergo supramolecular self-assembly and form solvent-filled, bilayer delineated capsules with sizes ranging from 20 nm to 2 microns depending on annealing temperatures and time. They are able to encapsulate different fluorescent dyes, therapeutic drugs, radionuclides and even small proteins. While sharing many properties with lipid vesicles, the BAPCs are much more robust. They have been analyzed for stability, size, cellular uptake and localization, intra-cellular retention and, bio-distribution both in culture and in vivo.

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“…Finally, niosomes tend to be smaller in size than liposomes allowing for increased cellular uptake. These similarities to liposomes and enhanced properties make niosome popular drug delivery carriers [71, 72]. …”

Section: Types Of Nanoparticles and Multi-loading Techniquesmentioning

confidence: 99%

“…Factors that affect the resulting niosome include the type of surfactant used, the hydration temperature, and the nature of the drug being used. These various synthesis methods and variety of materials need to be considered when synthesizing a niosome for drug delivery purposes [71, 72]. …”

Section: Types Of Nanoparticles and Multi-loading Techniquesmentioning

confidence: 99%

Nanoparticle Based Combination Treatments for Targeting Multiple Hallmarks of Cancer

VanDyke

Kyriacopulos

Yassini

et al. 2016

IJNST

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Treatment of cancer remains one of the most challenging tasks facing the healthcare system. Cancer affects the lives of millions of people and is often fatal. Current treatment methods include surgery, chemotherapy, radiation therapies or some combinations of these. However, recurrence is a major problem. These treatments can be invasive with severe side effects. Inefficacies in treatments are a result of the complex and variable biology of cancerous cells. Malignant tumor cells and normal functioning cells share many of the same biological characteristics but the main difference is that in cancer cells there is in an overuse and over expression of these biological characteristics. These pertinent characteristics can be grouped into eight hallmarks, as illustrated by Hanahan and Weinberg. These characteristics include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, reprogramming energy metabolism, and evading immune destruction. In order to provide a noninvasive, effective treatment, delivery methods must be explored in order to transport cytotoxic agents used for targeting the hallmarks of cancer in a safer and more effective fashion. The use of nanoparticles as drug delivery carriers provides an effective method in which multiple cytotoxic agents can be safely delivered to cancer tissue to simultaneously target multiple hallmarks. By targeting multiple hallmarks of cancer at once, the efficacy of cancer treatments could be improved drastically. This review explores the uses and efficacy of combination therapies using nanoparticles that can simultaneously target multiple hallmarks of cancer.

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Niosome: A future of targeted drug delivery systems

Cited by 412 publications

References 21 publications

Branched amphiphilic peptide capsules: Cellular uptake and retention of encapsulated solutes

Branched amphiphilic peptide capsules: Cellular uptake and retention of encapsulated solutes

A review of solute encapsulating nanoparticles used as delivery systems with emphasis on branched amphipathic peptide capsules

Nanoparticle Based Combination Treatments for Targeting Multiple Hallmarks of Cancer

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