In vitro and In vivo Studies of Drug-Drug Interaction between Metformin and Cefepime

Ferdous, Shomita; Sultan, Zakir; Bashar, Tafsir; Rahman, Asma; Islam, Saiful

doi:10.4172/2153-2435.1000348

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…Cefepime produced its characteristic peak at 185°C which is corresponding to its melting point. The peak appeared nearly in the same position in PM without any considerable changes 26 ( Figure 3D). a broadband at 3385 cm −1 , which is related to O-H stretching in agreement with previous studies 27,28 that confirm the formation of TDN.…”

Section: Characterizations Of Tdnmentioning

confidence: 78%

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Comparative Study of Antibacterial Effects of Titanium Dioxide Nanoparticles Alone and in Combination with Antibiotics on MDR Pseudomonas aeruginosa Strains

Ahmed¹,

Aly²,

El-Baky³

et al. 2020

IJN

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Introduction: The efficacy of several antimicrobial agents has been hindered due to the increasing frequency of multidrug-resistant (MDR) Pseudomonas aeruginosa strains. So, the need for new antibacterial drugs or drug combinations is urgent. Recently, desirable antibacterial effects were reported for many metals nanoparticles such as TiO 2 nanoparticles (TDNs). Purpose: This study aims to investigate the prevalence of MDR P. aeruginosa and assess the efficiency of TDN in the treatment of MDR P. aeruginosa-associated infections. Materials and Methods: The synthesis of TDN by the sol-gel method was carried out. Particle size measurements and morphology were done using dynamic light scattering (DLS) and high-resolution transmission electron microscopy (HR-TEM). To investigate the physical and chemical changes of drugs due to the combination, the tested drugs, both alone and in combination with TDN, were subjected to differential scanning calorimetry (DSC), infrared (IR) spectroscopy, and X-ray diffraction studies. Antimicrobial susceptibility was detected by agar disc-diffusion assay. The minimum inhibitory concentration (MIC) of TDN and the tested antibiotics were assessed by the agar dilution method. Checkerboard analysis was performed to determine the combined effect of TDN and the tested antibiotics against 25 MDR P. aeruginosa strains. Results: TDNs were prepared with an average particle size of 64.77 ± 0.14 nm with an accepted polydispersity index (PDI) value of 0.274 ± 0.004. TEM showed that the particles were shaped into irregular spheres. Twenty-five P. aeruginosa isolates that were absolutely resistant to cefepime (100%), highly resistant to ceftriaxone (96%), amikacin (80%), and ciprofloxacin (76%) were selected. Superior antibacterial activity of TDN was observed against the selected 25 MDR P. aeruginosa isolates. The combination of TDN and cefepime were found to show synergistic activity against all tested isolates followed by ceftriaxone (96%), amikacin (88%), and ciprofloxacin (80%). Conclusion: Using TDN in combination with antibiotics can help in the treatment of MDR P. aeruginosa-associated infections. So, preparation of topical pharmaceutical dosage forms containing a combination of these antibiotics and TDN can be useful against MDR P. aeruginosa.

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Section: Characterizations Of Tdnmentioning

confidence: 78%

“…That is close to the reported value. 26 Bands appeared in the PM in their proper positions without any significant shift ( Figure 4D). Data of IR and DSC supported the absence of interaction between tested drugs and TDN.…”

Section: Characterizations Of Tdnmentioning

confidence: 95%

Comparative Study of Antibacterial Effects of Titanium Dioxide Nanoparticles Alone and in Combination with Antibiotics on MDR Pseudomonas aeruginosa Strains

Ahmed¹,

Aly²,

El-Baky³

et al. 2020

IJN

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Thermochemical Properties and Bioactivity of the Metallic Complexes of Levofloxacin

Tahia

Sultan

Islam

et al. 2019

Asian J. Org. Med. Chem.

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The aim of this study was complexation of levofloxacin with iron, calcium, copper and ammonium salts. The formation of the metal complexes were confirmed by TLC and FT-IR. The newly formed metal complexes showed characteristics thermochemical behaviours such as differential scanning calorimetric and thermo gravimetric properties along with bioactivity. Additionally, the synthesized metal complexes have shown some extents of antimicrobial activities. It is concluded that the potentiality of metal-levofloxacin complexes are due to the action and presence of siderophores within bacterial cells.

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In vitro and In vivo Studies of Drug-Drug Interaction between Metformin and Cefepime

Cited by 2 publications

References 22 publications

<p>Comparative Study of Antibacterial Effects of Titanium Dioxide Nanoparticles Alone and in Combination with Antibiotics on MDR <em>Pseudomonas aeruginosa</em> Strains</p>

<p>Comparative Study of Antibacterial Effects of Titanium Dioxide Nanoparticles Alone and in Combination with Antibiotics on MDR <em>Pseudomonas aeruginosa</em> Strains</p>

Thermochemical Properties and Bioactivity of the Metallic Complexes of Levofloxacin

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