Depression and subsequent risk of Parkinson disease

Gustafsson, Helena; Nordström, Anna; Nordström, Peter

doi:10.1212/wnl.0000000000001684

Cited by 150 publications

(118 citation statements)

References 37 publications

Supporting

Mentioning

103

Contrasting

Unclassified

Order By: Relevance

“…Thus, depression might also be a factor that accelerates the onset of PD in vulnerable patients. A recently published cohort study also showed that having prior depression increases the risk of having a PD diagnosis in the following year by 3.2 times (30). In animal models where depression is modeled by chronic stress paradigms, increased HPA axis and oxidative stress, increased dendritic atrophy, decreased neurogenesis, and increased inflammation are shown (31,32).…”

Section: Discussionmentioning

confidence: 94%

Depression and Parkinson disease: prevalence, temporal relationship, and determinants

2017

View full text Add to dashboard Cite

Background/aim: Comorbidity of depression in Parkinson disease (PD) is a major factor that changes patients' quality of life. However, the neurobiological and sociodemographic risk factors for this comorbidity are not well studied. In this study, we aimed to define the prevalence, temporal relationship, and psychosocial and clinical determinants of depression comorbid with PD.Materials and methods: Fifty-five PD patients were evaluated with SCID, a data form that assessed sociodemographic and PD-related variables, UPDRS III, HAM-D, HAM-A, MMSE, and the Apathy Evaluation Scale.Results: Depression (lifetime: 45.5%, last month: 25.5%, before PD: 20%) was the most frequent psychiatric diagnosis. The major determinants of depression in the last month and depression before PD were early onset of PD and young age. Patients on pramipexole treatment were less likely to be diagnosed with depression in the last month. Other sociodemographic and PD-related variables were not significantly different for lifetime, last month, and pre-PD depression diagnosis compared to their counterparts. Conclusion:Depression is prevalent both before and after patient gets a PD diagnosis. Depression is not only the result of PD-related life changes but it is also a preceding factor that may decrease the age of PD onset.

show abstract

Section: Discussionmentioning

confidence: 94%

Depression and Parkinson disease: prevalence, temporal relationship, and determinants

2017

View full text Add to dashboard Cite

show abstract

“…12,14,24,34,35,38,40,48 Among the examined patient, most of the depression group was un-employed due to old age. It could not to be found an association between major depressive disorder in PD and in frequency of gender, residence, education, smoking and marital status.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors of Major Depressive Disorder in Parkinson’s Disease

Khalil¹,

Rahman²,

Munira

et al. 2018

Bangladesh Med Res Counc Bull

View full text Add to dashboard Cite

Depression in idiopathic Parkinson's disease is highly prevalent that can significantly impair the quality of life. Its exact mechanism of development is still poorly understood. It is well studied in western population but data from Asia especially in the South Asian region is limited. Considering this, to identify the potential risk factors of depression, a cross-sectional study was conducted among Parkinson's disease patients attending a tertiary care hospital in Bangladesh between July 2013-June 2014, in the Department of Neurology, Shaheed Suhrawardy Medical College and Hospital in Dhaka, Bangladesh. One hundred thirty seven cases of Parkinson's disease were enrolled, based on UK Parkinson's Disease Society Brain Bank criteria. Brain MRI was done in all cases, and patients with aphasia, significant cognitive deficits, secondary Parkinsonism were excluded. The overall prevalence of depression in the study population was 42%. There were no significant differences in gender, residence, education, smoking and marital status. In univariate analysis, age≥70 years, un-employed, right side predominantly involved, disease duration ≥5 years, sleep disturbance, postural instability, dose of levodopa ≥500 mg/day, Hoehn and Yahr stage ≥III and moderate to severe disability were significantly associated with depressive disorder. Whereas in multivariate linear stepwise regression model, age ≥70 years, (p=0.044), right side predominant involvement (p<0.001); sleep disturbance (p=0.006) and dose of levodopa ≥500 mg/day (p<0.001) were the major risk factors for depressive disorder. A significant proportion of Parkinson's disease patients suffer from depression. It was identified that depression in Parkinson's disease was significantly associated with advancing age, predominate right side involvement, sleep disturbance and higher daily dose of levodopa.

show abstract

“…Depression represents the most common psychiatric feature of PD [1] affecting from 17 to 22% of patients from the premotor until the advanced phases [2,3,4], leading to a worse quality of life [2]. In addition, depression in the early stages of PD may represent a risk factor for a more pronounced motor and cognitive decline [5].…”

Section: Introductionmentioning

confidence: 99%

Precuneal Thickness and Depression in Parkinson Disease

et al. 2016

View full text Add to dashboard Cite

Background: Depression-related gray matter changes in Parkinson disease (PD) patients have been reported, although studies investigating cortical thickness in early-stage disease are lacking. Objective: We aimed to evaluate cortical changes related to depression in early-stage PD patients with an extensive neuropsychological evaluation. Methods: 17 PD patients and 22 healthy controls underwent a 1.5-T brain MR protocol, and voxel-wise differences in cortical thickness among patients with (n = 6) and without (n = 11) depression and controls were evaluated using FreeSurfer software. Results: Cortical thickness was increased in the precuneus bilaterally in PD patients with depression compared to the other groups (number of vertices >100; p < 0.001, uncorrected) with a direct correlation with the Beck Depression Inventory score (p < 0.001, uncorrected). Conclusion: Precuneal cortical thickening is evident in PD patients with mild-moderate depression even in the early stages of the disease. This finding may reflect the early involvement of this region in the development of PD-related depression.

show abstract

Depression and subsequent risk of Parkinson disease

Cited by 150 publications

References 37 publications

Depression and Parkinson disease: prevalence, temporal relationship, and determinants

Depression and Parkinson disease: prevalence, temporal relationship, and determinants

Risk Factors of Major Depressive Disorder in Parkinson’s Disease

Precuneal Thickness and Depression in Parkinson Disease

Contact Info

Product

Resources

About