Cytomorphological study of lymph node lesions: a study of 250 cases

Abstract

Introduction: Lymph node enlargement is frequent presentation in all age groups with a wide spectrum of diseases, ranging from infections to malignancy. Therefore, management of cases depends on lymph node pathology, which can be studied by collecting material through fine needle aspiration method that can be used as an outpatient procedure. Objectives: The study was undertaken to assess the cytomorphological features and incidence of various lymph node diseases on fine-needle aspiration cytology (FNAC) and to analyze the utility and diagnostic importance of FNAC in lymph node diseases. Materials and Methods: In the study, total of 250 patients were selected who had presented with lymph node enlargement at Department of Pathology in our Tertiary Care Centre. Results: In this series of FNAC, cervical lymph nodes were involved in majority of 171 (68.4%) cases. The age of patients ranged from 6 months to 92 years with slight male preponderance. Tubercular lymphadenitis comprised the majority (50.8%) followed by reactive lymphoid lesions (20.8%), metastatic malignancies and acute suppurative lymphadenitis (8.8%) each, granulomatous lymphadenitis (8.4%), chronic nonspecific lymphadenitis (1.2%), necrotizing lymphadenitis (0.8%) and lymphoma (0.4%). Conclusion: FNAC is a simple, safe, reliable, inexpensive and the most diagnostic tool in early detection of lymph node lesions.

Study of fine needle aspiration cytology of cervical Lymph nodes in tertiary care Hospital

“…Reddy et al study showed that cervical and axillary group had 1-2cm size, > 1.5cms in the inguinal region and >0.5 cm at any other site are to be considered significant [18] . In our study tuberculosis lymphadenitis was the most common cause with most of the cases seen in the age group 30-50 years as compared with other studies Patel's AS et al study [13] , it was seen in third and fourth decade.The study done by Shilpa et al [19] and Kochhar et al [20] also found the highest incidence of Tuberculous lymphadenitis. Highest incidence of tuberculosis lymphadenitis cases due to the low socioeconomic status, poverty, illiteracy.…”

“…In our study, Lymphoma was seen in 2/100 (2%) cases, one patient's age was 30 years and other patient was 28 years both are Males. Cytomorphological diagnosis was Non Hodgkins Lymphoma in comparison with Mohanty et al [11] showing 3.66% and Patel's A.S et al [13] study 2.07% respectively. Flow cytometer and immunohistochemistry in adjunct to FNAC will help in the diagnosis of NHL.…”

“…In our study age group ranges from 2 years to 80 years with mean age of presentation being 40 years with slight male preponderance. Male to Female ratio 1.1:1 as compared with the Patel's AS et al [13] study and Khajuria et al [14] . But in Sharma et al [15] and Dura swami et al [16] showed that females were affected more commonly than males with male: female ratio of 0.87:1 and 1:1.6 respectively.…”

Cytomorphological Study of Lymphadenopathy at a Tertiary Health Care Hospital in Kathmandu

“…Similar finding was seen in a study done by Malhotra et al 18 where cervical region (71.7%) was the most affected one followed by axillary region (11.1%). Patel et al 19 also found the cervical lymph node (68.4%) as the most common finding followed by submandibular (10.8%), supraclavicular(10%) and axillary (5.2%) lymph nodes.…”

“…This finding was similar to other studies done in Nepal and different parts of India. [19][20][21] Reactive lymphadenitis 113 (34.1%) was the most common diagnosis followed by tubercular lymphadenitis 53 (16%). Several studies done in Nepal also showed reactive lymphadenitis as the most common diagnosis.…”