Cytologic Examination of the Skin and Subcutis

Duncan, Julie; Prasse, K. W.

doi:10.1016/s0091-0279(76)50085-2

Cited by 13 publications

(5 citation statements)

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“…In our study, FNAC was useful in the diagnosis of cutaneous nonneoplastic, inflammatory and noninflammatory conditions. However, especially for cutaneous and superficial masses, it is important to remember that neoplastic lesions may have an inflammatory component 5. Based on the 21 false negative diagnoses for neoplasia in inflammatory lesions in this study, an inflamed neoplasm can never be ruled out when only inflammatory cells are observed in the cytologic sample.…”

Section: Discussionmentioning

confidence: 89%

“…In veterinary medicine, the microscopic examination of cytologic specimens is a diagnostic aid of unquestioned value and applicable to a variety of organ systems, being a rapid, noninvasive, and economic means of obtaining a preliminary and often definitive diagnosis. A fine‐needle biopsy sample, collected either with or without aspiration is the preferred method for obtaining samples from superficial or deep masses both in humans1–4 and animals 5–8. Despite limitations,9 fine‐needle aspiration cytology (FNAC) is a procedure that should be considered in the same light as a surgical biopsy 10…”

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confidence: 99%

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Correlation between fine‐needle aspiration cytology and histopathology in the evaluation of cutaneous and subcutaneous masses from dogs and cats

Ghisleni

Roccabianca

Ceruti

et al. 2006

Veterinary Clinical Pathol

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Section: Discussionmentioning

confidence: 89%

mentioning

confidence: 99%

Correlation between fine‐needle aspiration cytology and histopathology in the evaluation of cutaneous and subcutaneous masses from dogs and cats

Ghisleni

Roccabianca

Ceruti

et al. 2006

Veterinary Clinical Pathol

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“…tumors (Sticker's sarcomas) and extramedullary plasmacytomas are the most common round cells tumors that can occur within the skin (Duncan and Prasse, 1976;Duncan and Prasse, 1979;Rebar, 1978;Barton, 1987;Villiers, 2003;Tyler et al, 2008).…”

Section: Epidemiological Aspects and Differential Diagnosis Of The Cumentioning

confidence: 99%

Epidemiological Aspects and Differential Diagnosis of the Cutaneous Round Cell Tumors in Dogs

Cora¹,

Gal²,

Taulescu³

et al. 2017

BUASVMCN-VM

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Round cell neoplasms (RCNs) are frequent cutaneous lesions in dogs, with high percentages among skin tumors. In this category are included histiocytoma, mast cell tumor, plasmacytoma, lymphoma and transmissible venereal tumor. The aim of the study was to perform an epidemiological study with reference to the cutaneous round cell tumors in a period of 10 years in the Department of Pathology (Faculty of Veterinary Medicine, ClujNapoca, Romania). Additionally, in the recorded cases with round cell tumors (mast cell tumor, histiocytoma and lymphoma) we described the main histological and cytological features. The epidemiological data were collected from the records of Pathology Department between 2005-2014. The investigation included dogs diagnosed with cutaneous round cell neoplasms, following necropsy analysis or assessment of biopsies or cytological samples. All collected specimens were analyzed by histopathological and/or cytological techniques. The staining used for histological investigation were Hematoxylin-eosin, Masson's trichrome and Toluidine blue, whereas Diff Quikand Wright methods were utilized in cytological specimens. The distribution of the cutaneous round cell tumors in relation to age, breed and sex was also assessed. The most frequent round cell tumor type was the mast cell tumor (19.54%) followed by histiocytoma (11.33%) and lymphoma (1.98%). The round cell tumors recorded were equally distributed in both males and females. Concerning the distribution of cutaneous RCNs by age (average age), histiocytoma occurred in 5 years old subjects, mast cell tumor in 11.9 years old subjects, and lymphoma in 6 years old subjects. Mast cell tumor was more frequent in stray dogs and Boxer breed, while histiocytoma occurred more commonly in stray dogs. Histological and cytological analysis was mandatory to perform the differential diagnosis between RCNs. Microscopic details concerning cytoplasm and nucleus of tumoral cells, together with the displaying mode in histological specimens may reveal the type of RCN. Cutaneous round cell tumors had an increased incidence, aspect observed in other reports too. The differential diagnosis has to rely on some specific microscopical features that can suggest the type of RCN.

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“…In the study of Simeonov [14], 19 cases with a diagnosis of infl ammation in cytology were diagnosed as tumor in histopathology. It should be remembered that infl ammation can coexist in tumors [29]. In our study, cytological diagnoses of fi ve infl ammatory reactions were changed as a papilloma, a sebaceous adenoma, a sebaceous hyperplasia, and two squamous cell carcinomas after histopathology.…”

Section: Discussionmentioning

confidence: 56%

Comparative Evaluation of the Cytological, Histopathological and Immunohistochemical Findings of Canine Cutaneous and Subcutaneous Masses

2021

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In this study, we compared the cytological, histopathological, and immunohistochemical diagnoses of 71 canine cutaneous and subcutaneous masses. Cytological diagnoses included 56 tumors (21 mesenchymal, 15 epithelial, 16 round cell, four melanocytic), 13 inflammatory reactions, and two cysts. Of the 21 cytologically diagnosed mesenchymal tumors, three were later confirmed non-tumoral (hematoma, granulation tissue, fibroepithelial polyp). Thirteen out of 15 epithelial tumors were correctly diagnosed cytologically, whereas two cases were confirmed to be non-tumoral (fibroepithelial polyp, granulation tissue) after histopathological examination. One mast cell tumor was later confirmed as fibrous hyperplasia; diagnoses were correct in other round cell tumors. Cytological diagnoses were correct for all melanocytic tumors and cystic lesions. Five cases which had been cytologically diagnosed as inflammatory reactions were diagnosed as tumors (lymphoma, papilloma, sebaceous adenoma, and squamous cell carcinoma) after histopathological examination. Immunohistochemistry confirmed the histopathological diagnoses of all epithelial and round cell tumors, while the diagnoses of six mesenchymal tumors were changed after the immunohistochemical examination. The total accuracy of cytology in the diagnosis of tumoral/non-tumoral masses was 84.5%, and the accuracy in the determination of benign/malignant behavior was 83%. Diagnostic accordance between histopathology and immunohistochemistry was 86.6%. High success rates obtained with cytological diagnoses prove that cytology is a reliable diagnostic tool. The main diagnostic challenge remains with mesenchymal tumors and tumors accompanied by inflammatory reactions. The results suggest that immunohistochemistry is fundamental for diagnoses of most mesenchymal tumors.

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Cytologic Examination of the Skin and Subcutis

Cited by 13 publications

References 2 publications

Correlation between fine‐needle aspiration cytology and histopathology in the evaluation of cutaneous and subcutaneous masses from dogs and cats

Correlation between fine‐needle aspiration cytology and histopathology in the evaluation of cutaneous and subcutaneous masses from dogs and cats

Epidemiological Aspects and Differential Diagnosis of the Cutaneous Round Cell Tumors in Dogs

Comparative Evaluation of the Cytological, Histopathological and Immunohistochemical Findings of Canine Cutaneous and Subcutaneous Masses

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