Cutaneous metastatic carcinoma of the breast mimicking malignant melanoma, clinically and histologically

Shamai‐Lubovitz, Orna; Rothem, A.; Ben‐David, Eitan; Sandbank, Miriam; Hauben, Daniel J.

doi:10.1016/s0190-9622(09)80086-8

Cited by 27 publications

(21 citation statements)

References 8 publications

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“…McDivitt and coworkers 2 reported a heavily pigmented mammary carcinoma clinically confused for malignant melanoma. Similar cases of pigmented epidermotropic metastatic breast carcinoma have since been reported 3–8 . These rare pigmented cutaneous metastases represent a distinct clinicopathologic variant that may be a clinical and histopathologic mimic of malignant melanoma 9 …”

mentioning

confidence: 63%

Cutaneous Metastatic Breast Carcinoma with Melanocyte Colonization: A Clinical and Dermoscopic Mimic of Malignant Melanoma

Wyatt

Agero²,

Delgado

et al. 2006

Dermatol Surg

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confidence: 63%

Cutaneous Metastatic Breast Carcinoma with Melanocyte Colonization: A Clinical and Dermoscopic Mimic of Malignant Melanoma

Wyatt

Agero²,

Delgado

et al. 2006

Dermatol Surg

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“…But if the melanin pigment is absent, the antibody PS100 could be a real support to diagnose melanoma. However, it should be remembered that an occasional carcinoma of breast had S100‐positive cells or contain melanin pigment, which could lead to a mistaken diagnosis of malignant melanoma 11 …”

Section: Discussionmentioning

confidence: 99%

Skin metastases from unknown origin: role of immunohistochemistry in the evaluation of cutaneous metastases of carcinoma of unknown origin

Azoulay¹,

Adem²,

Pelletier³

et al. 2005

J Cutan Pathol

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Determining the primary origin of skin metastases might be a challenging issue for pathologists, especially when there is no primary history or when this history is unavailable. The poor specificity of morphological appreciation is challenging, emphasizing the need for ancillary studies. We have retrieved 44 cases of skin metastases from our pathology files. Paraffin blocks were collected and homemade tissue arrays were made. We have tried to assess the primary origin based on morphological data alone, and then using 13 antibodies (cytokeratins (CK) 5/6, 7, 19, 20, thyroid transcription factor-1, carcinoembryonic antigen, PS100, tumor-associated glycoprotein 72, BerEP4, estrogen receptor (ER), progesterone receptor (PR), CD10, and E-cadherin). Most metastases in our series were from breast (13) and colorectal cancers (six) as they are the main clinical activity in our hospital. Only 44% of cases were correctly assessed based on the sole morphology, emphasizing the need for ancillary studies. CK 20, ER, and PR were the most helpful markers to determine the primary origin of skin metastases by highlighting colorectal origin and mammary origin, respectively. By far, clinical information and morphological evaluation are more reliable than the use of ancillary techniques, which have to be used in the absence of the former one and the poor differentiation of the latter ones. Azoulay S, Adem C, Le Pelletier F, Barete S, Francès C, Capron F. Skin metastases from unknown origin: role of immunohistochemistry in the evaluation of cutaneous metastases of carcinoma of unknown origin.

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“…4) (15). Histologically, zosteriform metastases show a prominent infiltration of the epidermis by neoplastic cells in a nesting or linear pattern, with focal formations of intraepidermal and subepidermal vesicles due to tumor cell discohesion and dermal edema (16). Several theories have been proposed to clarify the pathogenetic mechanism of zosteriform dissemination, though none has been adequately proven.…”

Section: Clinical Aspectsmentioning

confidence: 99%

Cutaneous manifestations of breast carcinoma

Giorgi¹,

Grazzini²,

Alfaioli³

et al. 2010

Dermatologic Therapy

101

152

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The incidence of breast carcinoma cutaneous manifestation in patients with breast carcinoma is 23.9%. The most common sites of breast carcinoma cutaneous manifestation are the chest wall and abdomen, but they can occur at the extremities and in the head/neck region. Due the high incidence of breast carcinoma, these cutaneous manifestations are the most common metastases seen by dermatologists. In clinical practice, cutaneous metastases show a wide range of clinical manifestations. Nodules are the most common presentation, but several other patterns are described below.

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Cutaneous metastatic carcinoma of the breast mimicking malignant melanoma, clinically and histologically

Cited by 27 publications

References 8 publications

Cutaneous Metastatic Breast Carcinoma with Melanocyte Colonization: A Clinical and Dermoscopic Mimic of Malignant Melanoma

Cutaneous Metastatic Breast Carcinoma with Melanocyte Colonization: A Clinical and Dermoscopic Mimic of Malignant Melanoma

Skin metastases from unknown origin: role of immunohistochemistry in the evaluation of cutaneous metastases of carcinoma of unknown origin

Cutaneous manifestations of breast carcinoma

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