Eleven patients with pemphigus vulgaris and with eye complaints had histopathological and direct immunofluorescence (DIF) studies on biopsies of their conjunctivae. In eight of the patients the ocular symptoms preceded the other manifestations of pemphigus. None of the 11 patients had any detectable conjunctival blisters or erosions. The conjunctivitis in three of the patients proved on histopathology and DIF to be a manifestation of pemphigus vulgaris. In the remaining patients, conjunctival hyperaemia with or without a mucoid discharge was observed, but there were no specific histopathological features, although one of them had a positive DIF.
Combined oesophageal adenocarcinoma and carcinoid in Barrett's oesophagis405 Waldum et al 5 suggest that the diffuse form of gastric carcinoma may be derived from ECL cells. They propose that the occasional mixed tumours seen in the stomach,9 of which this is the equivalent in the oesophagus, could occur by proliferation of a more primitive cell than the committed ECL cell or be the result of paracrine effects of mediators released by the endocrine cells themselves.
Two cases of clear cell acanthoma (CCA) with marked signs of cellular atypia and mitotic figures are reported. Although the nature of CCA is not completely understood, it is considered to be a benign epithelial tumor. Our cases show that these lesions can develop malignant features.
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