Nodular secondary syphilis mimicking cutaneous lymphoreticular process

Hodak, Emmilia; David, Michael; Rothem, A.; Bialowance, Moshe; Sandbank, Miriam

doi:10.1016/s0190-9622(87)70280-1

Cited by 42 publications

(28 citation statements)

References 9 publications

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“…In patients with HIV and syphilis, the clinical and histological appearance of PSL is different. Our case and those reported in the literature presented with non‐healing papules, some with central ulceration, lesions at palms and soles, general lymphadenopathy and other general symptoms, for example, weight loss or myalgia. These are classical signs of syphilis maligna.…”

Section: Discussionsupporting

confidence: 46%

CD8‐positive pseudolymphoma in lues maligna and human immunodeficiency virus with monoclonal T‐cell receptor‐beta rearrangement

Mitteldorf¹,

Plumbaum

Zutt

et al. 2018

J Cutan Pathol

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A 42‐year‐old Caucasian man suffered from disseminated plaques and ulcerated nodules for 6 weeks. He had weight loss and generalized lymphadenopathy. Underlying diseases were not known up till then. Based on a skin biopsy, the diagnosis of CD8‐positive cutaneous T‐cell lymphoma, type mycosis fungoides was made in a pathological reference center for lymphoma. A reproducible T‐cell receptor (TCR)‐beta rearrangement was detectable. Before starting therapy, a new biopsy was taken and the previous diagnosis was re‐evaluated taking clinical images and symptoms into account. Based on both, the diagnosis of a CD8+ pseudolymphoma in lues maligna and human immunodeficiency virus was made. We highlight histopathologic clues for the correct diagnosis, and we emphasize the indispensability of clinical‐pathological correlation. Furthermore, we discuss the differential diagnosis of CD8+ lymphoproliferative disorders.

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Section: Discussionsupporting

confidence: 46%

CD8‐positive pseudolymphoma in lues maligna and human immunodeficiency virus with monoclonal T‐cell receptor‐beta rearrangement

Mitteldorf¹,

Plumbaum

Zutt

et al. 2018

J Cutan Pathol

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“…Although syphilis was often in the clinical differential diagnosis of clinically nodular presentations of secondary syphilis, it was frequently of lower suspicion in the cases reviewed. The differential diagnoses were broad and included granuloma annulare, leprosy, psoriasis, lymphoma and sarcoidosis . In keeping with classical secondary syphilitic lesions, the majority of cases reviewed here described the skin lesions as painless and/or non‐pruritic.…”

Section: Discussionmentioning

confidence: 56%

“…Clinically, secondary syphilis most commonly presents with a generalized papulosquamous eruption accompanied by flu‐like symptoms and lymphadenopathy . However, other clinic presentations including macular, papular/nodular, lichen planus‐like, Sweet syndrome‐like, pustular, ulcerative and annular lesions with a tinea‐like appearance with or without systemic symptoms have been described with various underlying histopathologic patterns . As is typical with secondary syphilis, the cases of granulomatous secondary syphilis included in this review presented with a wide range of clinical appearances (Table ).…”

Section: Discussionmentioning

confidence: 99%

Nodular secondary syphilis with associated granulomatous inflammation: case report and literature review

2014

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A 62‐year‐old male presented with a 10‐day history of a diffuse, erythematous papular rash sparing the palms and soles. Histopathologic examination of a skin lesion showed loose non‐caseating granulomas in a lymphoplasmacytic background. Scattered spirochetes were identified by Treponema pallidum immunohistochemistry, in keeping with a diagnosis of secondary syphilis. Granulomatous inflammation in secondary syphilis is uncommon. A review of the literature reveals that the majority of prior reported cases of granulomatous secondary syphilis share similar characteristics to this case; namely, a papular or nodular clinical presentation, sparing of the palms and soles, and collections of epithelioid histiocytes with associated lymphocytes and variable numbers of plasma cells.

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“…The composition and depth of the infi ltrate can vary from area to area even within a single biopsy. Few cases of secondary syphilis with a dense and diffuse dermal lymphocytic infi ltrate have been reported to histologically mimic a lymphoid neoplasm (Cochran et al 1976 ;Goffi net et al 1970 ;Gollnick et al 1987 ;Hodak et al 1987 ).…”

Section: Histopathologymentioning

confidence: 99%

Cutaneous Hematopathology

2014

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Nodular secondary syphilis mimicking cutaneous lymphoreticular process

Cited by 42 publications

References 9 publications

CD8‐positive pseudolymphoma in lues maligna and human immunodeficiency virus with monoclonal T‐cell receptor‐beta rearrangement

CD8‐positive pseudolymphoma in lues maligna and human immunodeficiency virus with monoclonal T‐cell receptor‐beta rearrangement

Nodular secondary syphilis with associated granulomatous inflammation: case report and literature review

Cutaneous Hematopathology

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