77 Vitiligo patients were investigated for their HLA phenotype. Analysis of this material according to age of onset and ethnic origin revealed some significant characteristics. Young Jewish Moroccan patients showed a high frequency of B13 when compared to matching controls. Young patients of Yemenite origin had a strikingly high frequency of BW35. Jewish Yemenites showed a lack of B13 both in patients and in controls. It is suggested that studies be undertaken to clarify this problem further.
SUMMARY.— A study was carried out to observe the effect of the administration of varying amounts of prednisone, as well as of the antihistamine Incidal, upon the patch test reaction in patients who had previously shown a positive or strongly positive reaction with different substances. A daily dose of 40 mg prednisone given to 12 patientswasfound tosuppressthetest reaction completely in 3 patients and to diminish it in 8; in 1 case there was no change. With a daily dose of 30 mg given to 18 patients, the reaction was suppressed in 4 and diminished in 6 patients; in 8 no difference could be detected. In the 16 patients who were given a daily dose of 20 mg predispose, the test was completely suppressed in only 1, was diminished in 5 patients, and was unchanged in 10. In all of the 10 patients who were given the antihistamine Incidal (mebhydrolin napadisylate) no difference could be seen in the patch test reactions.
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