A Study of the Effect of Pkednisone and an Antihistamine on Patch Test Reactions

Feuerman, Eleasar J.; Levy, Aviad

doi:10.1111/j.1365-2133.1972.tb01895.x

Cited by 56 publications

(23 citation statements)

References 3 publications

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“…Antihistamines and disodium cromoglycate have not been reported to influence the allergic patch test reaction , and the same is true for NSAIDs. Concerning retinoids (alitretinoin), which are used in the treatment of hand dermatitis, there are no data in the literature.…”

Section: Influence Of Individual Factorsmentioning

confidence: 92%

European Society of Contact Dermatitis guideline for diagnostic patch testing – recommendations on best practice

et al. 2015

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SummaryThe present guideline summarizes all aspects of patch testing for the diagnosis of contact allergy in patients suspected of suffering, or having been suffering, from allergic contact dermatitis or other delayed-type hypersensitivity skin and mucosal conditions. Sections with brief descriptions and discussions of different pertinent topics are followed by a highlighted short practical recommendation. Topics comprise, after an introduction with important definitions, materials, technique, modifications of epicutaneous testing, individual factors influencing the patch test outcome or necessitating special considerations, children, patients with occupational contact dermatitis and drug eruptions as special groups, patch testing of materials brought in by the patient, adverse effects of patch testing, and the final evaluation and patient counselling based on this judgement. Finally, short reference is made to aspects of (continuing) medical education and to electronic collection of data for epidemiological surveillance.

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Section: Influence Of Individual Factorsmentioning

confidence: 92%

European Society of Contact Dermatitis guideline for diagnostic patch testing – recommendations on best practice

et al. 2015

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“…They do not suppress ACD. 9,10 In this study the early but not the with 250 mg ml Ϫ1 TMA, while a 50 mg ml Ϫ1 concentration caused an almost as high early swelling (Fig. 2).…”

Section: Ear Swelling Measurement Discussionmentioning

confidence: 48%

“…15 Interest-animals not sensitized to TMA than in those sensitized ANIMAL MODEL FOR CONTACT URTICARIA to suppress ACD in mice, 16 as well as allergic patch test reactions in humans. 9 Indomethacin suppresses NICU to benzoic acid, 17 cinnamic acid and cinnamic aldehyde. 8 Topical indomethacin does not have an effect on immediate skin prick reactions but it may aggravate dermographic urticaria 18 or mast cell-induced vasopermeability.…”

Section: Ear Swelling Measurement Discussionmentioning

confidence: 99%

Trimellitic anhydride‐sensitive mouse as an animal model for contact urticaria

1997

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The respiratory allergen trimellitic anhydride (TMA) has been shown to induce IgE production and immediate ear swellling in mice sensitized to it. We studied whether TMA sensitivity could be used as an animal model for immunological contact urticaria.BALB/C mice were sensitized to TMA by topical applications. Groups of animals were pretreated on the ears with the glucocorticosteroid (GCS) betamethasone-17,21-dipropionate, the antihistamine (AH) diphenhydramine hydrochloride, the non-steroidal anti-inflammatory drug (NSAID) indomethacin or vehicle (VEH). Ears were challenged with TMA and ear thickness was measured at baseline and 1, 2, 4, 8 and 24 h after challenge. Trimellitic anhydride caused a significant biphasic ear swelling response with an early peak at 1-2 h, a plateau at 4 h and a late peak at 24 h. However, there was also an early swelling by TMA in non-sensitized mice, suggesting that non-immunological as well as immunological mechanisms contribute to early swelling by TMA. Glucocorticosteroid suppressed significantly the early and to some extent the late TMA responses, while AH suppressed only early and NSAID only late TMA responses. Ear swelling in TMA-sensitive BALB/C mice may represent a combination of immunological and non-immunological contact urticaria and allergic contact dermatitis.Mice sensitive to TMA may be helpful in defining pharmacological agents affecting contact urticaria and the model is perhaps suitable for identification of some immunologically mediated contact urticants.

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“…In 1972, Feuerman and Levy 2 did not find any difference in patch test reactions in all 10 of their patients who were on the antihistamine mebhydroline napadisylate. A more recent double‐blind, placebo‐controlled, randomized, crossover study on a group of 27 patients 5 demonstrated that the clinical evaluation of patch test reactions is not hampered by antihistamines.…”

mentioning

confidence: 93%