Curative effect of <em>Plumbago indica</em> root extract on thioacetamide induced hepatotoxicity in experimental rats

Abstract

A b s t r a c tThe root parts of The study was designed to evaluate the hepato curative activity Plumb methanolic root extracts at different doses (100 and 200 mg/kg bw) against thioacetamide induced liver damag Thioacetamide (100 mg/kg bw) and was assessed by evaluating the activity of liver marker enzymes, antioxidant enzymes and lipid peroxidation. The liver sections were evaluated serum liver enzymes and hepatic levels of antioxidant markers. Histopathological findings also confirmed the curative effect of scientifically rationale the use of liver disorders.

Cytotoxic Plumbagin-5-O-α-l-Rhamnopyranoside from Plumbago indica

“…Previous chemical inspections on the different extracts of P. indica showed the presence of numerous active compounds such as plumbagin, 6-hydroxy plumbagin, plumbaginol (Dinda et al 1994), cyanidin, delphinidin, kaempferol (Harborne 1962), β-sitosterol, stigmasterol, and campesterol (Dinda and Chel 1992). Plumbago indica was reported to exhibit antiseptic, hepatoprotective, antioxidant, anti-fungal, antibacterial, antiparasitic, antitumor (Eldhose et al 2017), and antifertility (Sheeja et al 2008) activities. As a part of our interest in bioactive constituents from natural sources, we described in this report the isolation and identification of one new naphthoquinone glycoside, plumbagin-5-O-α-l-rhamnopyranoside (1) and seven known compounds.…”