Antioxidant and antiaging effect of traditional Thai rejuvenation medicines in Caenorhabditis elegans

Ruangchuay, Sutticha; Wang, Qiangqiang; Liang-yi, Wang; Lin, Jia-Rui; Wang, Yongchao; Zhong, Guohuan; Maneenoon, Katesarin; Huang, Zebo; Chusri, Sasitorn

doi:10.1016/j.joim.2021.03.004

Cited by 11 publications

(6 citation statements)

References 46 publications

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“…At the same time, following the simulation extension, more computation power will be required. Lastly, it is essential to emphasize that the authors’ simulation here is in line with a previous experimental finding reported by Ko et al in 2014 [ 2 ].…”

Section: Discussionsupporting

confidence: 91%

“…Even though the authors investigated Thai rejuvenating remedy No. 11 for the first time, the anti-pigmentation properties of both bioactive metabolites (glabridin and ethyl p -methoxycinnamate) found in the remedy were already reported before by Chen et al 2016 and Ko et al 2014 [ 2 , 3 ]. However, it does not mean that the authors’ results lack novelty since both studies investigated the activity of each metabolite as a pure component and studied them separately.…”

Section: Discussionsupporting

confidence: 54%

“…Thai rejuvenating remedy, also known as “Yaa-Aa-Yu-Wat-Ta-Na” in Thai, has been claimed to slow down the aging process and to nourish, reboot, and restore balance to the human body [ 1 , 2 ]. Typically, each Thai rejuvenating remedy consists of a specific medicinal plant mixture in various proportions, and each unique remedy claims specific therapeutic properties.…”

Section: Introductionmentioning

confidence: 99%

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In Vitro, In Vivo, and In Silico Analyses of Molecular Anti-Pigmentation Mechanisms of Selected Thai Rejuvenating Remedy and Bioactive Metabolites

et al. 2023

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Thai rejuvenating remedies are mixed herbal formulas promoting longevity. Due to the complexity, the biological activities of these remedies are minimal. Therefore, in this study, the authors evaluated the anti-pigmentation effect at the molecular level of the selected Thai rejuvenating remedy to fulfill the knowledge gap. First, the authors found that the selected remedy showed promising activity against the tyrosinase enzyme with an IC50 value of 9.41 µg/mL. In the comparison, kojic acid (positive control) exhibited an IC50 value of 3.92 µg/mL against the same enzyme. Later, the authors identified glabridin as a bioactive molecule against tyrosinase with an IC50 value of 0.08 µg/mL. However, ethyl p-methoxycinnamate was the most abundant metabolite found in the remedy. The authors also found that the selected remedy and glabridin reduced the melanin content in the cell-based assay (B16F1) but not in the zebrafish larvae experiment. Finally, the authors conducted a computational investigation through molecular docking proposing a theoretical molecular interplay between glabridin, ethyl p-methoxycinnamate, and target proteins (tyrosinase and melanocortin-1 receptor, MC1R). Hence, in this study, the authors reported the molecular anti-pigmentation mechanism of the selected Thai rejuvenating remedy for the first time by combining the results from in silico, in vitro, and in vivo experiments.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

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In Vitro, In Vivo, and In Silico Analyses of Molecular Anti-Pigmentation Mechanisms of Selected Thai Rejuvenating Remedy and Bioactive Metabolites

et al. 2023

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“…Assessment of the free radical scavenging activity of the extracts was conducted using a mixed-mode mechanism, as outlined in previously published studies focusing on DPPH radicals. 3,15 The efficacy of the standard reference compound, Trolox, and the test extracts were quantified in terms of their 50% inhibitory concentration (IC50) values, expressed in milligrams per milliliter (mg/mL), against radicals. The extracts were prepared in two-fold serial dilutions ranging from 2500 to 1.22 micrograms per milliliter (µg/mL).…”

Section: 1-diphenyl-2-picrylhydrazyl (Dpph) Assaymentioning

confidence: 99%

“…A slightly modified Folin-Ciocalteu (FC) method was used to determine the total phenolic content (TPC) of the polyherbal extract as well as the extracts obtained from its herbal components. 3,15 Initially, 120 microliters (µL) of each extract, with a concentration of 2.5 milligrams per milliliter (mg/mL), were combined with 1000 µL of a 10-fold diluted FC reagent and allowed to react for 5 minutes. Following this, 1000 µL of a 20% weight/volume (w/v) sodium carbonate solution (sourced from Ajax Finechem, New Zealand) was added to the mixture.…”

Section: Total Phenolic Content (Tpc)mentioning

confidence: 99%

Evaluation of In Vitro Antioxidant Activities and Toxicity Effects of a Novel Plant-Based Body Lotion from Thai Medicinal Plants

2024

TJNPR

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In Thailand, several polyherbal formulations have been used for treating various diseases, including skin infections. 10 In the present work, a polyherbal formulation for treating skin diseases, known as THR-01, consisting of Rhinacanthus nasutus (Acanthaceae), Quisqualis indica (Combretaceae), Ocimum sanctum (Lamiaceae), Vitex glabrata (Verbenaceae), and Stemona tuberosa (Stemonaceae) was chosen for testing its antioxidant activities and safety. Interestingly, Stemona tuberosa, one of the primary components of this formulation was found to exhibit significant antioxidant properties with low toxicity. Plant roots of the Stemona genus, part of the Stemonaceae family, have historically been a part of traditional Chinese medicine, valued for their capabilities in repelling insects and relieving coughs. The root extracts of these plants can be applied for external use in repelling various insect pests. [11][12][13] Additionally, Stemona root extracts exhibit promising antibacterial properties against some skin infecting pathogens. According to previous research, ethanol extracts of Stemona tuberosa roots have been shown to suppress a broad spectrum of bacteria and fungi. 11 More recent studies have isolated eight new alkaloids from the roots of Stemona tuberosa and one of these compounds showed good anti-inflammatory activity. 14 Therefore, to develop an effective herbal product for external use, especially for the skin, an extract of Stemona tuberosa, the active component of a traditional formula used for treating skin diseases in Southern Thailand, was tested for its antioxidant activity using 1,1diphenyl-2-picrylhydrazyl (DPPH), total phenolic content (TPC), and ferric-reducing antioxidant power (FRAP) assays. Its toxicity profile using an in vivo model, Galleria mellonella larvae, was determined, ensuring the safety of the extract for potential cosmetic use, according to the aim of this research. Moreover, consumer acceptance of the resulting body lotion containing various concentrations of Stemona tuberosa extracts was assessed, focusing on sensory attributes such as

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Antioxidant Peptides Derived from Millet Bran Promote Longevity and Stress Resistance in Caenorhabditis elegans

Li,

Xu,

Zhang

et al. 2023

Plant Foods Hum Nutr

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Antioxidant and antiaging effect of traditional Thai rejuvenation medicines in Caenorhabditis elegans

Cited by 11 publications

References 46 publications

In Vitro, In Vivo, and In Silico Analyses of Molecular Anti-Pigmentation Mechanisms of Selected Thai Rejuvenating Remedy and Bioactive Metabolites

In Vitro, In Vivo, and In Silico Analyses of Molecular Anti-Pigmentation Mechanisms of Selected Thai Rejuvenating Remedy and Bioactive Metabolites

Evaluation of In Vitro Antioxidant Activities and Toxicity Effects of a Novel Plant-Based Body Lotion from Thai Medicinal Plants

Antioxidant Peptides Derived from Millet Bran Promote Longevity and Stress Resistance in Caenorhabditis elegans

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