Antioxidant Peptides Derived from Millet Bran Promote Longevity and Stress Resistance in Caenorhabditis elegans

Li, Chen; Xu, Wenjing; Zhang, Xiangyu; Cui, Xiaodong; Tsopmo, Apollinaire; Li, Jiao

doi:10.1007/s11130-023-01100-7

Cited by 3 publications

(6 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, functional millet bran peptides (MBPE) can overall increase the mean lifespan of C. elegans, especially with a 29% increase in the 12.5 µg/mL MBPE-treated group. In addition, based on the solid susceptibility of C. elegans, movement and reproductive rates were jointly used to synergistically evaluate the antiaging effect of antioxidant peptides [13]. Meanwhile, the transparent nature of C. elegans makes fluorescent probe techniques for detecting OS still applicable.…”

Section: Caenorhabditis Elegans (C Elegans)mentioning

confidence: 99%

“…These models share the advantages of small size, low maintenance costs, and few ethical concerns [12]. Notably, the embryos and larvae of zebrafish and C. elegans are transparent throughout the body, thus enabling direct in vivo ROS detection with various fluorescent probes [13,14]. Meanwhile, human aging is closely associated with OS [15].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

New Insights into Antioxidant Peptides: An Overview of Efficient Screening, Evaluation Models, Molecular Mechanisms, and Applications

Zhang,

Li,

Quan

et al. 2024

Antioxidants

View full text Add to dashboard Cite

Antioxidant peptides are currently a hotspot in food science, pharmaceuticals, and cosmetics. In different fields, the screening, activity evaluation, mechanisms, and applications of antioxidant peptides are the pivotal areas of research. Among these topics, the efficient screening of antioxidant peptides stands at the forefront of cutting-edge research. To this end, efficient screening with novel technologies has significantly accelerated the research process, gradually replacing the traditional approach. After the novel antioxidant peptides are screened and identified, a time-consuming activity evaluation is another indispensable procedure, especially in in vivo models. Cellular and rodent models have been widely used for activity evaluation, whilst non-rodent models provide an efficient solution, even with the potential for high-throughput screening. Meanwhile, further research of molecular mechanisms can elucidate the essence underlying the activity, which is related to several signaling pathways, including Keap1-Nrf2/ARE, mitochondria-dependent apoptosis, TGF-β/SMAD, AMPK/SIRT1/PGC-1α, PI3K/Akt/mTOR, and NF-κB. Last but not least, antioxidant peptides have broad applications in food manufacture, therapy, and the cosmetics industry, which requires a systematic review. This review introduces novel technologies for the efficient screening of antioxidant peptides, categorized with a new vision. A wide range of activity evaluation assays, encompassing cellular models, as well as rodent and non-rodent models, are provided in a comprehensive manner. In addition, recent advances in molecular mechanisms are analyzed with specific cases. Finally, the applications of antioxidant peptides in food production, therapy, and cosmetics are systematically reviewed.

show abstract

Section: Caenorhabditis Elegans (C Elegans)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

New Insights into Antioxidant Peptides: An Overview of Efficient Screening, Evaluation Models, Molecular Mechanisms, and Applications

Zhang,

Li,

Quan

et al. 2024

Antioxidants

View full text Add to dashboard Cite

show abstract

“…Twenty milligrams of sample was mixed with cholesterol solution at various concentrations (0.537-1.564 mg mL −1 ) and shaken at 37 °C for 1 h. The cholesterol concentration was determined using the o-phthalaldehyde method, and the CAC was calculated according to Eqn (7).…”

Section: Effect Of Initial Cholesterol Concentrationmentioning

confidence: 99%

“…Subsequently, the mixtures were incubated at 37 °C for the designated times (0-180 min). The cholesterol concentration was determined using the o-phthalaldehyde method, and the CAC was calculated according to Eqn (7).…”

Section: Effect Of Adsorption Time and Phmentioning

confidence: 99%

“…5,6 In addition, polysaccharides, polyphenols, and peptides extracted from millet bran are believed to have antidiabetic potential and antioxidant health benefits. 7,8 The additive and synergistic effects of phytochemicals in millet bran may improve its functional properties, such as hypoglycemic and lipid-lowering activity. 9 Currently, the focus of reports on millet bran primarily revolves around the extraction of individual components (such as polypeptides, dietary fiber, polyphenols, and millet bran oil) and their respective properties.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Fermentation of millet bran with Bacillus natto: enhancement of bioactivity levels and the bioactivity of bran extract

Zhang,

Wang,

et al. 2024

J Sci Food Agric

View full text Add to dashboard Cite

BackgroundMillet bran (MB), a byproduct of millet production, is rich in functional components, but has a low utilization rate. In recent years, researchers have shown that fermentation can improve the biological activities of cereals and their byproducts. This study used Bacillus natto to ferment millet bran to improve its added value and broaden the application areas of MB. The bioactive component content, physicochemical properties, and functional activities of millet bran extract (MBE) from fermented millet bran were determined.ResultsAfter fermentation, the contents of soluble dietary fiber (SDF), β‐glucan, polypeptides, polyphenols, flavones, and total amino acids increased by 92.0%, 164.4%, 111.4%, 32.5%, 16.4%, and 95.4%, respectively. Scanning electron microscopy revealed that the microscopic morphology of MBE changed from complete and dense blocks to loosely porous shapes after fermentation. After fermentation, the solubility, water holding capacity, and viscosity significantly increased, and the particle size decreased. Moreover, the glucose adsorption capacity (2.1 mmol/g), glucose dialysis retardation index (75.3%), and α‐glucosidase inhibitory (71.4%, mixed reversible inhibition) activity of the fermented MBE (FMBE) were greater than those of the unfermented MBE (0.99 mmol/g, 32.1%, and 35.1%, respectively). FMBE presented better cholesterol and sodium cholate (SC) adsorption properties, and the adsorption was considered inhomogeneous surface adsorption.ConclusionFermentation increased the bioactive component content and improved the physicochemical properties of MBE, thereby improving its hypoglycemic and hypolipidemic properties. This study will not only resolve the problem of millet bran waste but also promote the development of a higher value‐added application method for millet bran.This article is protected by copyright. All rights reserved.

show abstract

Antioxidant Peptides and Protein Hydrolysates from Tilapia: Cellular and In Vivo Evidences for Human Health Benefits

Ng,

Wong,

Abd Manan

et al. 2024

Foods

View full text Add to dashboard Cite

Antioxidant peptides derived from aquatic organisms have attracted tremendous research interest due to their potential applications in human health. Tilapia is one of the most widely farmed aquaculture species globally. The current understanding of tilapia-derived antioxidant peptides is gradually expanding. This review discusses the current knowledge of peptides and protein hydrolysates derived from tilapia muscle, skin, and scales, whose antioxidant capacity has been validated in various cellular and in vivo models. To date, at least 16 peptides and several hydrolysates have been identified from tilapia that protect human and non-human cell models against oxidative injury. Tilapia hydrolysates and peptide mixtures have also shown protective effects in animal models of oxidative stress-associated diseases and exercise-induced oxidative injury and fatigue. The key mechanisms of tilapia hydrolysates and peptide mixtures involve enhancing antioxidant enzyme activities and suppressing radical production. Notably, such hydrolysates also exerted additional in vivo functions, such as anti-inflammatory, anti-diabetic, wound healing, and antiaging properties. Taken together, tilapia-derived antioxidant peptides and hydrolysates represent a valuable source of functional ingredients for applications in functional food, dietary supplements, and therapeutic applications. Continued research into their health benefits is warranted in the future.

show abstract

Antioxidant Peptides Derived from Millet Bran Promote Longevity and Stress Resistance in Caenorhabditis elegans

Cited by 3 publications

References 27 publications

New Insights into Antioxidant Peptides: An Overview of Efficient Screening, Evaluation Models, Molecular Mechanisms, and Applications

New Insights into Antioxidant Peptides: An Overview of Efficient Screening, Evaluation Models, Molecular Mechanisms, and Applications

Fermentation of millet bran with Bacillus natto: enhancement of bioactivity levels and the bioactivity of bran extract

Antioxidant Peptides and Protein Hydrolysates from Tilapia: Cellular and In Vivo Evidences for Human Health Benefits

Contact Info

Product

Resources

About