Controllable synthesis of poly(acrylic acid)-stabilized nano-hydroxyapatite suspension by an ultrasound-assisted precipitation method

Yan, Dong; Lou, Yuxin; Han, Yingchao; Wickramaratne, M. Nirmali; Dai, Hongyue; Wang, Xinyu

doi:10.1016/j.matlet.2018.04.124

Cited by 12 publications

(8 citation statements)

References 16 publications

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“…Processes 2019, 7, 826 5 of 12 and 631 cm −1 [29]. The weak absorption bands at 1408, 1456 cm −1 were observed for samples HAP and HAP-LA as reported for carbonated HAP, which could result from the presence of atmospheric carbon dioxide during calcination processes [30,31]. The presence of TCP is also shown by the stretching frequency of the phosphate group at 2360 cm -1 [15] for the HAP and HAP-LA samples.…”

Section: Resultssupporting

confidence: 57%

Drug Leaching Properties of Vancomycin Loaded Mesoporous Hydroxyapatite as Bone Substitutes

et al. 2019

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Infections after bone reconstructive surgery become an authentic therapeutic and economic issue when it comes to a modern health care system. In general; infected bone defects are regarded as contraindications for bone grafting. Since the pathogens develop a biofilm on the inner surface of the bone; local delivery of antibiotics becomes more important. The present work focuses on the synthesis of Mesoporous Hydroxyapatite (MPHAP) loaded with drug Vancomycin (Van) and to investigate its loading and leaching ability in phosphate buffer solution (PBS), to be used for post-operative infections. The effect of pore size on MPHAP was analyzed using different fatty acids as organic modifiers. The impacts of various fatty acids chain length on the morphology and pore size were studied. A simple impregnation technique with optimized conditions ensured a high antibiotic loading (up to 0.476 + 0.0135 mg/mL), with a complete in vitro release obtained within 50 h.

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Section: Resultssupporting

confidence: 57%

Drug Leaching Properties of Vancomycin Loaded Mesoporous Hydroxyapatite as Bone Substitutes

et al. 2019

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“…36,37 And the ultrasonic atomization is to convert a solution into mist-like droplet with a certain energy by ultrasonic nebulizer and then spray it into another reaction solution over a large area, so that it is possible to obtain uniformly dispersed and ne nano-powder. 38 Therefore, the M-H method has a greater advantage than the traditional hydrothermal method.…”

Section: Resultsmentioning

confidence: 99%

Large-scale and fast synthesis of nano-hydroxyapatite powder by a microwave-hydrothermal method

et al. 2019

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“…Simulations of HAP-polymer interfacial molecular interactions demonstrated that the most favorable orientation of PAA for the interaction with HAP is along the c-axis of HAP aligned parallel to polymer chains for in situ HAP, contrary to ex situ HAP/PAA composites where the (001) HAP surface is the most probable plane for adsorption of PAA molecules [ 51 ]. The change in HAP particle morphology from rod-like to spherical as well as the structural change from nanocrystalline to amorphous phase was observed with increasing content of the PAA from 0.3 to 0.5 mg/mL during precipitation [ 52 ]. Thus, the refinement of HAP particles at a higher PAA content in CXI cements as well as the rise of the spherical fraction at the expense of rod-like particles can be associated with the change in the type of PAA adsorption in relation to HAP planes.…”

Section: Discussionmentioning

confidence: 99%

“…No such morphological type of particles was documented in the microstructure of CXI cements which clearly demonstrates the strong influence of polymeric additives on particle growth and formation of CXI cement microstructure. On the other hand, the significant effect of PAA concentration was demonstrated during precipitation of HAP where a rise in PAA concentration from 0.3 to 0.5 mg/mL caused the structural change from nanocrystalline to amorphous phase [ 52 ].

3CaHPO 4 +H 2 O → 3Ca 2+ + 3H 3 O + + 3PO 4 3− ↓ Ca 5 (PO 4 ) 3 OH + H 2 O …”

Section: Discussionmentioning

confidence: 99%

Injectable Enzymatically Hardened Calcium Phosphate Biocement

Medvecký

Štulajterová

Giretová

et al. 2020

JFB

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(1) Background: The preparation and characterization of novel fully injectable enzymatically hardened tetracalcium phosphate/monetite cements (CXI cements) using phytic acid/phytase (PHYT/F3P) hardening liquid with a small addition of polyacrylic acid/carboxymethyl cellulose anionic polyelectrolyte (PAA/CMC) and enhanced bioactivity. (2) Methods: Composite cements were prepared by mixing of calcium phosphate powder mixture with hardening liquid containing anionic polyelectrolyte. Phase and microstructural analysis, compressive strength, release of ions and in vitro testing were used for the evaluation of cement properties. (3) Results: The simple possibility to control the setting time of self-setting CXI cements was shown (7–28 min) by the change in P/L ratio or PHYT/F3P reaction time. The wet compressive strength of cements (up to 15 MPa) was close to cancellous bone. The increase in PAA content to 1 wt% caused refinement and change in the morphology of hydroxyapatite particles. Cement pastes had a high resistance to wash-out in a short time after cement mixing. The noncytotoxic character of CX cement extracts was verified. Moreover, PHYT supported the formation of Ca deposits, and the additional synergistic effect of PAA and CMC on enhanced ALP activity was found, along with the strong up-regulation of osteogenic gene expressions for osteopontin, osteocalcin and IGF1 growth factor evaluated by the RT-qPCR analysis in osteogenic αMEM 50% CXI extracts. (4) Conclusions: The fully injectable composite calcium phosphate bicements with anionic polyelectrolyte addition showed good mechanical and physico-chemical properties and enhanced osteogenic bioactivity which is a promising assumption for their application in bone defect regeneration.

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Controllable synthesis of poly(acrylic acid)-stabilized nano-hydroxyapatite suspension by an ultrasound-assisted precipitation method

Cited by 12 publications

References 16 publications

Drug Leaching Properties of Vancomycin Loaded Mesoporous Hydroxyapatite as Bone Substitutes

Drug Leaching Properties of Vancomycin Loaded Mesoporous Hydroxyapatite as Bone Substitutes

Large-scale and fast synthesis of nano-hydroxyapatite powder by a microwave-hydrothermal method

Injectable Enzymatically Hardened Calcium Phosphate Biocement

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