Injectable Enzymatically Hardened Calcium Phosphate Biocement

Medvecký, Ľubomír; Štulajterová, Radoslava; Giretová, Maria; Luptáková, Lenka; Sopčák, Tibor

doi:10.3390/jfb11040074

Cited by 8 publications

(12 citation statements)

References 73 publications

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“…Hydrogels based on hydrogen and ionic bonds can be easily affected by pH, temperature, and humidity, as well as the molecular weight and crosslinking degree of polymer materials. It is possible to adjust the hydrogel composition such that its swelling rate, water content, and degradation time, as well as its plasticity and hardness, are affected 79 , 80 . As CMC and PAA are mixed, they intertwine to form polymers based on electric charges, which increases the material’s hardness, promotes swelling reduction, and prolongs degradation (Fig.…”

Section: Discussionmentioning

confidence: 99%

Biomineralization-inspired mineralized hydrogel promotes the repair and regeneration of dentin/bone hard tissue

et al. 2023

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Maxillofacial hard tissue defects caused by trauma or infection often affect craniofacial function. Taking the natural hard tissue structure as a template, constructing an engineered tissue repair module is an important scheme to realize the functional regeneration and repair of maxillofacial hard tissue. Here, inspired by the biomineralization process, we constructed a composite mineral matrix hydrogel PAA-CMC-TDM containing amorphous calcium phosphates (ACPs), polyacrylic acid (PAA), carboxymethyl chitosan (CMC) and dentin matrix (TDM). The dynamic network composed of Ca2+·COO− coordination and ACPs made the hydrogel loaded with TDM, and exhibited self-repairing ability and injectability. The mechanical properties of PAA-CMC-TDM can be regulated, but the functional activity of TDM remains unaffected. Cytological studies and animal models of hard tissue defects show that the hydrogel can promote the odontogenesis or osteogenic differentiation of mesenchymal stem cells, adapt to irregular hard tissue defects, and promote in situ regeneration of defective tooth and bone tissues. In summary, this paper shows that the injectable TDM hydrogel based on biomimetic mineralization theory can induce hard tissue formation and promote dentin/bone regeneration.

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Section: Discussionmentioning

confidence: 99%

Biomineralization-inspired mineralized hydrogel promotes the repair and regeneration of dentin/bone hard tissue

et al. 2023

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“…Even though hydrogels provide a friendlier environment for cells in terms of toxicity and ability to replicate a highly hydrated microenvironment, the mechanical properties are much lower than those of thermoplastics [91] or cements. [92,93] In fact, stiffness values of hydrogels, which researchers have been able to control and tune to best fit their applications, vary from below 100 Pa to over 100 kPa. [94][95][96] While these are the ideal mechanical requirements for tissues like vasculature, brain, or soft organs, it is often insufficient to mimic the properties of structural tissues.…”

Section: Hybridmentioning

confidence: 99%

Keeping It Organized: Multicompartment Constructs to Mimic Tissue Heterogeneity

Sanchez‐Rubio

Jayawarna

Maxwell

et al. 2023

Adv Healthcare Materials

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Tissue engineering aims at replicating tissues and organs to develop applications in vivo and in vitro. In vivo, by engineering artificial constructs using functional materials and cells to provide both physiological form and function. In vitro, by engineering three‐dimensional (3D) models to support drug discovery and enable understanding of fundamental biology. 3D culture constructs mimic cell–cell and cell–matrix interactions and use biomaterials seeking to increase the resemblance of engineered tissues with its in vivo homologues. Native tissues, however, include complex architectures, with compartmentalized regions of different properties containing different types of cells that can be captured by multicompartment constructs. Recent advances in fabrication technologies, such as micropatterning, microfluidics or 3D bioprinting, have enabled compartmentalized structures with defined compositions and properties that are essential in creating 3D cell‐laden multiphasic complex architectures. This review focuses on advances in engineered multicompartment constructs that mimic tissue heterogeneity. It includes multiphasic 3D implantable scaffolds and in vitro models, including systems that incorporate different regions emulating in vivo tissues, highlighting the emergence and relevance of 3D bioprinting in the future of biological research and medicine.

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“…Some authors even suggest the use of more than one additive, obtaining a hybrid material with improved injectability, anti-washout and self-setting properties [ 150 ]. It is clear that addition of different additives can aid calcium phosphate functionality, however it should be noted that additives may have an effect on other aspects of implant properties.…”

Section: Additivesmentioning

confidence: 99%

“…Most popular CaP compound employed in the reviewed patent documents is α-TCP [ [144] , [145] , [146] , [147] , [148] , [149] , [150] , [151] , 151 , 152 , [152] , [152] , [153] , [154] , [155] , [156] , [157] , [158] , [159] , [160] , [161] , [162] , [163] , [164] , [165] , [166] , [167] , [168] , [169] , [170] ], although there are some documents that use β-TCP as well [ 153 , 159 , [162] , [163] , [164] , [165] , [166] , 172 ]; in some documents ACP also appears [ 160 , 166 , 169 , 173 ]. Tendency to use more than one CaP form can also be observed [ 153 , [158] , [159] , [160] , [162] , [163] , [164] , [165] , [166] , 169 , 170 , 172 , 174 ].…”

Section: Recent Developments In Patentsmentioning

confidence: 99%