Large-scale and fast synthesis of nano-hydroxyapatite powder by a microwave-hydrothermal method

Cai, Zhengwei; Wang, Xinyu; Zhang, Zongrui; Han, Yingchao; Luo, Jing; Huang, Mingzheng; Zhang, BoWen; Hou, Yuanjing

doi:10.1039/c9ra00091g

Cited by 23 publications

(15 citation statements)

References 37 publications

(28 reference statements)

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“…, [7] ), spray cooling [8] , film coating [9] , [10] , preparation of micro- and/or nano-sized powder ( e.g. , [11] ), air purification [12] , [13] , [14] , [15] , medical applications ( e.g. , [16] , [17] , [18] ), and applications utilizing sonochemical reactions/reactors associated with cavitation ( e.g.…”

Section: Introductionmentioning

confidence: 99%

Periodicity in ultrasonic atomization involving beads-fountain oscillations and mist generation: Effects of driving frequency

Wang

Mori

Tsuchiya

2022

Ultrasonics Sonochemistry

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Section: Introductionmentioning

confidence: 99%

Periodicity in ultrasonic atomization involving beads-fountain oscillations and mist generation: Effects of driving frequency

Wang

Mori

Tsuchiya

2022

Ultrasonics Sonochemistry

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“…where V 112/300 is the intensity of the hollow between ( 112) and (300) planes and I 300 is the intensity of the (300) plane. 24,30 In parallel with the qualitative analysis, the production yield was calculated to assess the efficacy with respect to the theoretical yield from the stoichiometrically balanced reaction scheme. This is very important from the industrial perspective, where any probable inverse relationship between quality and yield should be minimal.…”

Section: Powder Characterizationmentioning

confidence: 99%

“…There are several attempts reported in the literature to produce HAp in large scales. Cai et al 24 demonstrated the efficacy of a microwave-based hydrothermal method to accelerate HAp powder production on a large scale. It was observed that with the reaction temperature and time of 160 • C and 40 min, respectively, .4 mol L −1 concentration of Na 2 HPO 4 , 12H 2 O maximized the yield of nano-HAP powder (.033 kg L −1 ).…”

Section: Introductionmentioning

confidence: 99%

Pilot‐scale manufacturing of phase‐pure and highly crystalline hydroxyapatite: Lessons learned and process protocols

Barui

Hadagalli

Mukherjee

et al. 2021

Int J Applied Ceramic Tech

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The recognition of hydroxyapatite (HAp) as the major bone mineral triggered significant research in bone tissue engineering applications. Although laboratoryscale development involves the synthesis of HAp in different routes, scalability with uncompromised quality remains a major challenge. This article reports a large-scale wet precipitation-based synthesis of phase-pure HAp using indigenously customized stirred tank reactors. The different synthesis parameters, like pH, reaction time, stirring rate, precursor addition, were tailored, together with the post-synthesis mechano-chemical treatment (aging induced Ostwald ripening) and calcinations, as the technology is matured to manufacture HAp powders in large volume. At least three batches of HAp were produced in the pilotscale reactor with reproducible values of phase purity, compositional fingerprint, particle size distribution, flowability, etc. The post-calcination bluish tint was strategically addressed by adopting a proprietary calcination protocol. This batch process can produce around 200 kg/month of phase-pure and highly crystalline (91-94%) HAp using stirred tank reactors of different working volumes. Extensive scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analyses reveal the particle size of as-synthesized HAp powders with hexagonal crystal structure in the range of 20.47 ± 4.95 nm , while individual crystallite size in range of 22.3 ± 3.2 nm (XRD based Debye-Scherrer analysis). TEM-based SADP analysis confirms the highly crystalline hexagonal structure of as-synthesized HAp. The spray-dried powders with spherical shape having narrow size distribution (35-40 μm) could also be manufactured in large batches. The spray-dried HAp powders could be coated on clinically used stainless steel femoral stem implants using atmospheric plasma spray coating technique.

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“…dextran, CS, alginate, gelatin, carboxymethyl cellulose) [5], CS is known to form an excellent composite with HAp due to their reconcilable properties such as biocompatibility, biodegradability [5], chelation, and adsorption properties [6]. Several methods for synthesizing HAp and CS such as the green method [7][8][9][10] and chemical method [11][12][13][14] have been reported in the literature. The majority of these studies are focused on the influence of synthesis routes and precursors on the biological and physicochemical properties of HAp and CS, such as thermal stability [15,16], and solubility [17,18], crystallinity [19,20], and hardness [21,22].…”

Section: Introductionmentioning

confidence: 99%

Microstructural analysis of biowaste‐derived hydroxyapatite‐chitosan nanocomposites

Shah

Joshi

Rai

et al. 2022

Micro & Nano Letters

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In recent years, considerable attention is given in various nanomaterials development using biodegradable wastes for establishing more eco‐friendly technologies. Due to the biocompatible, biodegradable, and non‐toxic nature hydroxyapatite (HAp) and chitosan (CS) are highly studied in recent times. In this research work, HAp and CS were synthesized in a nanometric range using the bio‐wastes obtained from chicken bones and pila shells, respectively. In addition, HAp/CS nanocomposites were also prepared through the co‐precipitation method in various weight ratios. The synthesized nanomaterials and nanocomposites were characterized by X‐ray diffraction (XRD) and Fourier Transform Infrared (FTIR) spectroscopy. The XRD pattern analysis revealed the hexagonal crystalline structure of HAp and orthorhombic crystallite structure of CS with crystallite sizes of 40.52 and 39.51 nm, respectively. The physical parameters such as d‐spacing, dislocation density, stacking fault probability, and lattice strain of HAp and CS were also analyzed. The FTIR spectra analysis confirmed the formation of HAp and CS. Likewise, the broadening and weakening of the chemical bond between two phases of HAp and CS indicated the bond formation and compatibility between HAp and CS.

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Large-scale and fast synthesis of nano-hydroxyapatite powder by a microwave-hydrothermal method

Abstract: The obtained nano-HAP still has high crystallinity, uniform size and good dispersibility when the concentration of Na2HPO4 is 0.4 mol L−1.

Cited by 23 publications

References 37 publications

Periodicity in ultrasonic atomization involving beads-fountain oscillations and mist generation: Effects of driving frequency

Periodicity in ultrasonic atomization involving beads-fountain oscillations and mist generation: Effects of driving frequency

Pilot‐scale manufacturing of phase‐pure and highly crystalline hydroxyapatite: Lessons learned and process protocols

Microstructural analysis of biowaste‐derived hydroxyapatite‐chitosan nanocomposites

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