Contact dermatitis associated with <i>Astronium urundeuva</i> (allemão) Engl., a traditional medicinal plant from Brazil

Vilar, Maria do Livramento Leitão; Diógenes, M. J. N.; Vilar, Janaina L.; Filho, José Gomes Bezerra; Dantas, Joana D'arc Pereira; Souza, Júlia Aparecida L. De; Morais, Selene Maia de

doi:10.1111/j.0105-1873.2004.0459a.x

Cited by 7 publications

(4 citation statements)

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“…Tannins at high concentrations usually inhibit enzyme activity but, at low concentrations, they often stimulate enzyme activity. Later on (Vilar et al, 2004), a contact dermatitis associated with the use of Astronium urundeuva (syn. M. urundeuva) in humans was also reported, pointing out that more toxicological preclinical as well as clinical studies should be carried out, not only with the species crude extracts but also with its bioactive compounds.…”

Section: Resultsmentioning

confidence: 99%

Antiinflammatory and antiulcer properties of tannins from Myracrodruon urundeuva Allemão (Anacardiaceae) in Rodents

Souza

Aquino

Milach

et al. 2007

Phytotherapy Research

133

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Myracrodruon urundeuva Allemão is a plant utilized in Northeast Brazil as an antiinflammatory, wound healing and in gynecological illnesses. The objectives of the present study were to evaluate the antiinflammatory and antiulcer properties of the tannin-enriched fraction (TEF) isolated from the stem bark of M. urundeuva, in the formalin test, in mice, and in carrageenan-induced paw edema and gastric ulcer models, in rats. The results showed that TEF dose-dependently inhibited both phases of the formalin test. However, the effect was predominant in the 2nd phase of the response where inhibitions of 47%, 76% and 85% were observed, with doses of 5, 10 and 50 mg/kg, i.p. In the carrageenan-induced paw edema, significant inhibitions were observed at 3 h (44%) and 4 h (28%), with a dose of 10 mg/kg, i.p. TEF also significantly decreased by 37%, 43% and 57% gastric ulceration induced by indomethacin, at doses of 10, 20 and 50 mg/kg p.o. In the ethanol-induced gastric ulcer model, TEF was less effective, and significant inhibitions (42% to 46%) were observed only with doses of 100 and 200 mg/kg, p.o., respectively. In conclusion, it was shown that TEF presents antiinflammatory and antiulcer effects, partly due to its antioxidant action, known to be present in polyphenols, including tannins.

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Section: Resultsmentioning

confidence: 99%

Antiinflammatory and antiulcer properties of tannins from Myracrodruon urundeuva Allemão (Anacardiaceae) in Rodents

Souza

Aquino

Milach

et al. 2007

Phytotherapy Research

133

View full text Add to dashboard Cite

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“…There are few studies about its healing effects, 21,22 especially on skin, and possibility of photosensitization and contact dermatitis. [23][24][25] It is emphasized that only six out of 36 patients practicing self-medication used adequate treatment, such as scabicide lotion, oral ivermectin or both. Dermatologists, in general, did not consider scabicide soaps alone as appropriate treatment for scabies.…”

Section: Discussionmentioning

confidence: 99%

Percepção da doença e automedicação em pacientes com escabiose

Kovács

Brito

2006

An. Bras. Dermatol.

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FUNDAMENTOS: A situação de alta prevalência da escabiose, associada ao baixo grau de autodiagnóstico e à estigmatização dos parasitados, contribui para a automedicação. OBJETIVOS: Verificar a percepção dos pacientes com escabiose em relação à doença, às possibilidades diagnósticas consideradas, à automedicação realizada e os sentimentos diante do conhecimento do diagnóstico. MÉTODOS: Em estudo prospectivo de série de casos, foram entrevistados 65 pacientes com diagnóstico clínico de escabiose atendidos no ambulatório de Dermatologia do Hospital das Clínicas da Universidade Federal de Pernambuco, em Recife, Brasil. RESULTADOS: Apenas 47,7% deles acreditavam que seus sintomas fossem devidos à escabiose, e 86% achavam que esses poderiam ser devidos a outras enfermidades, como infecções, picada de insetos e alergia a contactantes. Como automedicação, observada em 55,4% dos pacientes, os produtos mais utilizados foram os sabões e as plantas. O diagnóstico da escabiose levou a sentimentos negativos em 56,7% dos casos. CONCLUSÕES: O estudo evidenciou ser baixo o grau de suspeição de escabiose entre os infestados. A automedicação foi utilizada em mais da metade dos pacientes, geralmente com produtos inadequados para o tratamento da parasitose. É freqüente o diagnóstico da escabiose levar a sentimentos negativos, indicando a importância da atenção integral ao paciente.

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“…In another, previous study, colophony had been identified as an additional allergen, indicating contact allergy to oxidized resin acids introduced into cutting fluids by the addition of tall oil [84]. Further 'new' allergens reported during the period analyzed are presented in Table 1 [ [85][86][87][88][89][90][91][92][93][94][95][96][97][98][99].…”

Section: Occupational Contact Allergymentioning

confidence: 99%