Clinical update on contact allergy

Uter, Wolfgang; Johansen, Jeanne Duus; Orton, David; Frosch, Peter J.; Schnuch, Axel

doi:10.1097/01.all.0000182548.60595.80

Cited by 11 publications

(6 citation statements)

References 98 publications

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“…Other important cosmetic allergens include fragrances (fragrance mix), balsam of Peru (Myroxylon pereirae resin) and preservatives [e.g. methyldibromo glutaronitrile (MDBGN)] (3,16,17). In our subgroup, the frequency of sensitization to none of these allergens was higher than in the remainder of the IVDK patients.…”

Section: Discussionmentioning

confidence: 69%

“…Sensitizations to the fragrance mix and balsam of Peru were even slightly, but significantly, underrepresented. MDBGN has increasingly been used in the last decade in many cosmetics, not only in products intended for use on the scalp (17). As its use in leave‐on products – applied to sites other than the scalp – was banned by the European Union regulatory institutions only in March 2005 (Commission directive 2003/833/EC), it is not surprising that the sensitization frequency found in our collective did not differ from the remainder of the IVDK collective.…”

Section: Discussionmentioning

confidence: 70%

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Patch test results in patients with scalp dermatitis: analysis of data of the Information Network of Departments of Dermatology*

2007

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 70%

Patch test results in patients with scalp dermatitis: analysis of data of the Information Network of Departments of Dermatology*

2007

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“…Weak haptens including dyes, preservatives, perfumes, metal ions, and drugs are the most frequently encountered haptens in humans (Saint-Mezard et al, 2004b;Uter et al, 2005). They can induce sensitization in a small proportion of individuals only and mostly those who frequently manipulate the hapten (occupational disease) (Buckley et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

CD8+ T Cells Are Effector Cells of Contact Dermatitis to Common Skin Allergens in Mice

Vocanson

Hennino

Cluzel-Tailhardat

et al. 2006

Journal of Investigative Dermatology

127

112

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Allergic contact dermatitis (ACD) to strong experimental haptens is mediated by specific CD8+ T cells. Here, we show that similar mechanisms occur for weak haptens, which comprise the vast majority of chemicals responsible for human ACD. We used a model of ACD, that is, the contact hypersensitivity reaction, to test for the allergenicity of three weak haptens involved in fragrance allergy. ACD to weak haptens could not be induced in normal mice. In contrast, mice acutely depleted in CD4+ T cells developed a typical ACD reaction to the three weak fragrance allergens that peaked 24 hours after challenge. Priming of CD8+ T cells was observed in draining lymph nodes 5 days after sensitization and development of ACD was associated with the infiltration of activated CD8+ T cells in the challenged skin. CD8+ T cells were effectors of the ACD reaction as in vivo treatment with depleting anti-CD8 mAbs abrogated the ACD responses and as purified CD8+ T cells could adoptively transfer ACD to naive recipients. In conclusion, our data demonstrate a dominant role of CD8+ T cells as initiators of ACD to weak haptens, and suggest that CD8+ T cells may represent potential targets for preventing or treating ACD.

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“…Contact allergy is an acquired immunological alteration resulting in allergic reactions of the skin (allergic contact dermatitis) after contact with a sufficient amount of the "allergen" in those who became sensitised (allergic) during an earlier exposure to the specific trigger. Allergens comprise natural as well as man-made substances and abound in the (work) environment [13]. However, those affected by allergic contact dermatitis only partly consult the medical system [14].…”

Section: Definition Of Contact Allergy and Its Clinical Surveillancementioning

confidence: 99%

Registries in Clinical Epidemiology: the European Surveillance System on Contact Allergies (ESSCA)

Uter¹,

Schnuch²,

Wilkinson³

et al. 2016

Methods Inf Med

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SummaryBackground: Disease registries rely on consistent electronic data capturing (EDC) pertinent to their objectives; either by using existing electronic data as far as available, or by implementing specific software solutions.Objectives: To describe the current practice of an international disease registry (European Surveillance System on Contact Allergies, ESSCA, www.essca-dc.org) against different state of the art approaches for EDC.Methods: Since 2002, ESSCA is collecting data, currently from 53 departments in 12 countries. Departmental EDC software ranges from spreadsheets to comprehensive “patch test software” based on a relational database. In the Erlangen data centre, such diverse data is imported, converted to a common format, quality checked and pooled for scientific analyses.Results: Feed-back to participating departments for quality control is provided by standardised reports. Varying author teams publish scientific analyses addressing the objective of contact allergy surveillance.Conclusions: Although ESSCA represents a historically grown, heterogeneous network and not one unified approach to EDC, some of its features have contributed to its viability in the last 12 years and may be useful to consider for similar investigator-initiated networks.

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Clinical update on contact allergy

Abstract: Constant awareness for new allergens, confirmed by critical evaluation, standardization of patch test materials, and the identification of temporal patterns and subgroups at risk will improve both the diagnosis and prevention of allergic contact dermatitis.

Cited by 11 publications

References 98 publications

Patch test results in patients with scalp dermatitis: analysis of data of the Information Network of Departments of Dermatology*

Patch test results in patients with scalp dermatitis: analysis of data of the Information Network of Departments of Dermatology*

CD8+ T Cells Are Effector Cells of Contact Dermatitis to Common Skin Allergens in Mice

Registries in Clinical Epidemiology: the European Surveillance System on Contact Allergies (ESSCA)

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