Considerations of renal, hepatic and extremital arteriovenous differences in concentration of radiomercury of a mercurial diuretic

Milnor, Pervis; Burch, George E.; Ray, Thorpe; Threefoot, Sam A.; Berenson, Gerald S.

doi:10.1016/0002-9343(49)90451-9

Cited by 4 publications

(5 citation statements)

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“…The above results are an extension of the work of others who have demonstrated that the mercury in a mercurial diuretic is found in highest concentration in the kidney (2,3).…”

Section: Discussionsupporting

confidence: 84%

“…Further studies have shown that following administration of such compounds to humans and to animals a higher concentration of mercury is found in the kidney than in the other tissues examined, (2,3) and it appears that renal binding precedes the onset of diuresis (4,5). A number of such investigations have been carried out with the use of diuretics labelled with Hge0' (2,3), and this isotope administered as HgCl2 has been found by radioautographic means in high concentration in the renal cortex of rats (6).…”

mentioning

confidence: 98%

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Distribution of Radiomercury Administered as Labelled Chlormerodrin (Neohydrin®) in the Kidneys of Rats and Dogs 1

Greif¹,

Sullivan²,

Jacobs³

et al. 1956

J. Clin. Invest.

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“…The above results are an extension of the work of others who have demonstrated that the mercury in a mercurial diuretic is found in highest concentration in the kidney (2,3).…”

Section: Discussionsupporting

confidence: 84%

mentioning

confidence: 98%

Distribution of Radiomercury Administered as Labelled Chlormerodrin (Neohydrin®) in the Kidneys of Rats and Dogs 1

Greif¹,

Sullivan²,

Jacobs³

et al. 1956

J. Clin. Invest.

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“…Transfer into tubular urine might deented by Milnor, pend on diffusion forces. This view is suggested Berenson (21), by the observation that the administration of the eralluride in man. sulfhydril compound, BAL, causes the rapid disMllowing: the mer-charge of Chlormerodrin from the kidney, for the plasma, is rapidly most part into the urine, but also into the renal h thereafter serve venous blood.…”

Section: Discussionmentioning

confidence: 99%

PLASMA REGRESSION, DISTRIBUTION AND EXCRETION OF RADIOMERCURY IN RELATION TO DIURESIS FOLLOWING THE INTRAVENOUS ADMINISTRATION OF Hg203 LABELLED CHLORMERODRIN TO THE DOG 1

Borghgraef¹,

Kessler²,

Pitts³

1956

J. Clin. Invest.

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METHODSOur experiments, some 34 in all, have been performed on female mongrel dogs lightly anesthetized with sodium pentobarbital. Arterial blood samples were drawn through an indwelling needle in the femoral artery. In certain experiments renal venous blood samples were drawn through a polyethylene catheter, introduced by way of the jugular vein and positioned in the right renal vein by manipulation through an abdominal incision. Urine samples were collected either through a Foley catheter, introduced into the bladder or through ureteral catheters, inserted by way of an abdominal incision.The creatinine clearance has been employed as a measure of glomerular filtration rate and the creatinine clearance, divided by the plasma extraction ratio and corrected for urine flow (2, 3), has been employed as a measure of renal plasma flow. Chemical methods have been described in previous communications from this (4) and other (5) laboratories.Chlormerodrin (3-chloromercuri-2-methoxy-propylurea, Neohydrin@) has been synthesized in our laboratory using radiomercury, Hg", according to directions supplied

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“…For example, meralluride ( Mercuhydrin, methoxymercuripropylsuccinyl urea) had an extraction ratio of from 0.05 to 0.25 in one stud y 58 and from 0.05 to 0.38 in another. 31 Since 1949, Hg203 has been used as a label for mercurial diuretics!9 In normal subjects the half-time of Hg203-labeled meralluride in the blood is much less than in patients with renal disease. In normal persons, biliary excretion is slight, but it is quite significant in patients with renal disease.…”

Section: Renal Diseasementioning

confidence: 99%

Radioactive pharmaceuticals

Wagner¹

1963

Clin Pharma and Therapeutics

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It is important to use radioactive isotopes with no beta raciiations, or with low energy beta radiations. Because scintillation detectors which effectively measure only gamma radiation are most often used, beta radiation contributes to radiation dosage but provides no data. Special pharmaceutical problems associated with radiopharmaceuticals are:(1) problems of carrier-free state, ie., those arising because of the extremely small chemical quantities; (2) problems of self-decomposition, produced by the effect of radiation on the compound itself or on its solvent; (3) problems resulting from isotope effect, i.e., differences in reaction rates that sometimes result from differences in atomic weight of isotopes; and (4) problems resulting from chemical differences betwecn labeled and naturally occurring compounds.

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Considerations of renal, hepatic and extremital arteriovenous differences in concentration of radiomercury of a mercurial diuretic

Cited by 4 publications

References 0 publications

Distribution of Radiomercury Administered as Labelled Chlormerodrin (Neohydrin®) in the Kidneys of Rats and Dogs 1

Distribution of Radiomercury Administered as Labelled Chlormerodrin (Neohydrin®) in the Kidneys of Rats and Dogs 1

PLASMA REGRESSION, DISTRIBUTION AND EXCRETION OF RADIOMERCURY IN RELATION TO DIURESIS FOLLOWING THE INTRAVENOUS ADMINISTRATION OF Hg203 LABELLED CHLORMERODRIN TO THE DOG 1

Radioactive pharmaceuticals

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