No abstract

The mercurial diuretics in commiiiion use today exhibit certain basic similarities in structure. All are mercurated derivatives of substituted three carbon compounds of the type indicated below, in which the three substituents are designated X, OY, and R.H H H X-Hg-C-C-C(-R HOY H According to Friedman ( 1 ), the nature of the X substituent (usually halogen, theophylline or thioglycolate) has no effect on diuretic potency if the compound is given intravenously, but does influence both hyperacute (cardiac and respiratory arrest) and acute (7 to 14-day) renal toxicity.

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METHODSOur experiments, some 34 in all, have been performed on female mongrel dogs lightly anesthetized with sodium pentobarbital. Arterial blood samples were drawn through an indwelling needle in the femoral artery. In certain experiments renal venous blood samples were drawn through a polyethylene catheter, introduced by way of the jugular vein and positioned in the right renal vein by manipulation through an abdominal incision. Urine samples were collected either through a Foley catheter, introduced into the bladder or through ureteral catheters, inserted by way of an abdominal incision.The creatinine clearance has been employed as a measure of glomerular filtration rate and the creatinine clearance, divided by the plasma extraction ratio and corrected for urine flow (2, 3), has been employed as a measure of renal plasma flow. Chemical methods have been described in previous communications from this (4) and other (5) laboratories.Chlormerodrin (3-chloromercuri-2-methoxy-propylurea, Neohydrin@) has been synthesized in our laboratory using radiomercury, Hg", according to directions supplied