Actions of inhibitor compounds on adenine nucleotides of renal cortex and sodium excretion

Abstract

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Effect of Extracellular Volume Expansion on Renal Na-K-ATPase and Cell Metabolism

“…Although control values of ATP concentration in renal cortex observed in the present study are con siderably lower than those reported by Jones and Welt [22], they are in good agreement with those reported by Chignell and Titus [13] and Schmuckler et al [52], and are considerably higher than values reported by U rbaitis and K essler [55]. The variation of values for ATP concentration in renal tissue noted in the literature may be due primarily to the different techniques used to prevent degradation of ATP and to the delay of time from interruption of blood flow to tissue fixation through either boiling or freezing.…”

“…An analogous situation has been reported by U rbaitis and K essler [55], who observed a relative increase in renal cortical ATP levels following the injection of ouabain into the renal artery, interpreting these results as indicative of decreased ATP utilization following inhibition of Na-K-ATPase.…”

“…Most metabolic inhibitors which block ATP synthesis have been shown to affect sodium transport, for which about 80% of oxygen consumed by the kidney is utilized [58]. Cyanide, for example, when injected into the renal artery, decreases renal oxygen con sumption and sodium reabsorption [12,29,55,57] in a parallel fashion, but has no effect on Na-K-ATPase activity [1], Under these circumstances, cor tical ATP levels have been found to be depressed [29].…”

Effects of Ischemia on Metabolite Concentrations in Dog Renal Cortex

“…Variations in species and methodology may account for some of the differences in results; therefore, only major differences will be commented upon. The present data for ATP and ATP/ADP agree closely to values reported in rat kidney and liver [7,8,16], However, the presently measured ATP concentration of renal cortex is considerably higher than that reported by Urbaitis and Kessler [11] and the present ATP/ADP ratio is also higher than that reported previously [11]. One explanation for this discrepancy may be the time taken for complete freezing of the tissue [25].…”

Effect of Fructose and Mannitol on Dog Renal Cortical Adenine Nucleotide Content, in vivo

“…A number of metabolic inhibitors which cause a decrease in adenosine triphosphate (ATP) have been used to study the inter relation between renal transport and energy metabolism [11,13]. Most of the compounds used in previous studies were inhibitors of the electron transport system, uncoupling agents, or inhibitors of glycolysis and generally toxic [11,13], In the present study we have investi gated the effects of another compound, fruc tose, which has a different mode of action in decreasing ATP content, and which is less toxic.…”