Studies on Structure Diuretic Activity Relationships of Organic Compounds of Mercury 1

Kessler, R H; Lozano, R.L.; Pitts, Robert F.

doi:10.1172/jci103466

Cited by 68 publications

(11 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mercurial diuretics act by blocking the reabsorption of a part of the filtered sodium. Although they may have some action on every site of sodium reabsorption within the nephron, their major effect is on the neutral or sodium chloride transport system (5,6,14). Both cyanide and chlormerodrin blocked the reabsorption of about 10 to 30% of the filtered sodium chloride and reduced oxygen consumption in rough proportion.…”

Section: Discussionmentioning

confidence: 99%

Effects of Chlormerodrin, p-Chloromercuribenzoate and Dichlorphenamide on Renal Sodium Reabsorption and Oxygen Consumption

Kessler¹,

Weinstein²,

Nash³

et al. 1964

Nephron

View full text Add to dashboard Cite

We administered an organic mercurial diuretic compound, an organic mercurial non-diuretic compound and an inhibitor of carbonic anhydrase to anesthetized dogs. Using conventional clearance methods, we measured renal plasma flow, filtration rate, sodium reabsorption and oxygen consumption. The mercurial diuretic compound blocked a fraction of both sodium reabsorption and oxygen consumption. The non-diuretic compound affected neither sodium reabsorption nor oxygen consumption. The inhibitor of carbonic anhydrase blocked the reabsorption of a fraction of the filtered sodium without affecting oxygen consumption. We conclude that (1) sodium chloride reabsorption is dependent upon oxidative metabolism for energy; (2) binding of renal cortical sulfhydryl compounds affects neither sodium transport nor oxidative metabolism; (3) the mechanism for sodium reabsorption by ion exchange is not dependent upon oxidative metabolism for energy.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Chlormerodrin, p-Chloromercuribenzoate and Dichlorphenamide on Renal Sodium Reabsorption and Oxygen Consumption

Kessler¹,

Weinstein²,

Nash³

et al. 1964

Nephron

View full text Add to dashboard Cite

show abstract

“…forms of mercury has been considered as evidence that the organic compounds act as intact molecules rather than by the rupture of a carbon to mercury bond (9). Experiments were therefore done to compare mercuric cysteine and meralluride over a wide dosage range.…”

Section: Resultsmentioning

confidence: 99%

“…The relative ineffectiveness of mercuric chloride, when compared to organic mercurials, has previously been considered as evidence against the thesis that the diuretic activity of the organic compounds is attributable to the mercuric ion itself (9). However, the argument loses validity by the demonstration that the mercuric cysteine complex is more potent than the organic mercurials thus far tested.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Acid-Base Balance on the Diuresis Produced by Organic and Inorganic Mercurials1

Levy¹,

Weiner²,

Mudge³

1958

J. Clin. Invest.

View full text Add to dashboard Cite

Changes in acid-base metabolism have been recognized for many years as one of the most important factors influencing the magnitude of the diuretic response to organic mercurials. Diuresis is potentiated during metabolic acidosis and is suppressed during metabolic alkalosis. The mechanism by which these effects are mediated has been the subject of a number of studies. In general, two separate points of view have been considered: first, that they are attributable to changes in pH which presumably either modify the metabolic fate of the mercurial 4 or alter the affinity of a renal component for the drug; and secondly, that the responsiveness of the kidney varies with alterations in the ionic composition of the plasma which are independent of pH. Evidence in support of the latter thesis has been presented by Axelrod and Pitts (1) in studies on respiratory and metabolic acidosis. These authors have postulated that the concentration of chloride in the glomerular filtrate is the major factor that determines the effect of organic mercurials. Although this thesis has been widely accepted in recent years, there are a number of observations which cannot be explained by

show abstract

“…2) may be best explained in terms of mercuric ion levels. Thus Kessler et al, (1957) have observed in dogs that, whereas low doses of mercuric chloride (1 and 2 mg/kg mercury) produces diuresis, a higher dose (4 mg/kg mercury) actually inhibits urine flow. The inhibition of urine flow in dogs was associated with a collapse in the glomerular filtration rate.…”

Section: Discussionmentioning

confidence: 99%

THE MECHANISM OF ACTION OF MERCURIAL DIURETICS IN RATS; THE RENAL METABOLISM OF p‐CHLOROMERCURIBENZOATE AND ITS EFFECTS ON URINARY EXCRETION

Clarkson

Greenwood

1966

British Journal of Pharmacology and Chemotherapy

View full text Add to dashboard Cite

Studies on Structure Diuretic Activity Relationships of Organic Compounds of Mercury 1

Cited by 68 publications

References 6 publications

Effects of Chlormerodrin, p-Chloromercuribenzoate and Dichlorphenamide on Renal Sodium Reabsorption and Oxygen Consumption

Effects of Chlormerodrin, p-Chloromercuribenzoate and Dichlorphenamide on Renal Sodium Reabsorption and Oxygen Consumption

The Effects of Acid-Base Balance on the Diuresis Produced by Organic and Inorganic Mercurials1

THE MECHANISM OF ACTION OF MERCURIAL DIURETICS IN RATS; THE RENAL METABOLISM OF p‐CHLOROMERCURIBENZOATE AND ITS EFFECTS ON URINARY EXCRETION

Contact Info

Product

Resources

About