PLASMA REGRESSION, DISTRIBUTION AND EXCRETION OF RADIOMERCURY IN RELATION TO DIURESIS FOLLOWING THE INTRAVENOUS ADMINISTRATION OF Hg203 LABELLED CHLORMERODRIN TO THE DOG 1

Abstract

METHODSOur experiments, some 34 in all, have been performed on female mongrel dogs lightly anesthetized with sodium pentobarbital. Arterial blood samples were drawn through an indwelling needle in the femoral artery. In certain experiments renal venous blood samples were drawn through a polyethylene catheter, introduced by way of the jugular vein and positioned in the right renal vein by manipulation through an abdominal incision. Urine samples were collected either through a Foley catheter, introduced into the bladder or through ureteral catheters, inserted by way of an abdominal incision.The creatinine clearance has been employed as a measure of glomerular filtration rate and the creatinine clearance, divided by the plasma extraction ratio and corrected for urine flow (2, 3), has been employed as a measure of renal plasma flow. Chemical methods have been described in previous communications from this (4) and other (5) laboratories.Chlormerodrin (3-chloromercuri-2-methoxy-propylurea, Neohydrin@) has been synthesized in our laboratory using radiomercury, Hg", according to directions supplied

Studies on Structure Diuretic Activity Relationships of Organic Compounds of Mercury 1

“…Although chlormerodrin, which is the most active of the diuretics studied, is also most highly concentrated in the kidney, the degree of concentration of the remaining compounds seems entirely unrelated to diuretic potency. Figure 5 illustrates the distribution of mercury in the kidney in four experiments in (9). Results presented in this paper demonstrate that non-diuretic compounds of mercury are likewise concentrated in kidney tissue and that their distribution within renal cortex, medulla and papilla is both qualitatively and quantitatively similar to that of diuretic compounds.…”

“…Mercuhydring (6,7) and Neohydring (8,9) have been shown to disappear rapidly from the blood stream following intravenous administration and to accumulate in the renal cortex in high concentration. Both drugs are highly bound to plasma proteins, hence are sparingly filtered through the glomerular capillaries, yet both are rapidly eliminated in the urine.…”

“…Chemical procedures employed in the analyses of blood, urine and tissue samples are those described in a previous communication (9 taken up by cortical tissue, half the maximum concentration being attained in 15 minutes. The concentration of chlormerodrin in the kidney reached a peak about one and one-half hours after intravenous injection and then gradually declined.…”

Molecular imaging using the theranostic agent 197(m)Hg: phantom measurements and Monte Carlo simulations

“…The first application of radioactive mercury isotopes for nuclear medicine imaging was 60 years ago [ 1 , 2 ]. However, radiomercury became unappealing due to neurotoxic side effects [ 5 , 6 ].…”

“…One such radioisotope is mercury 197 Hg and its metastable state 197m Hg, henceforth referred to as 197(m) Hg. Radiomercury in the form of 203 Hg was initially investigated for clinical use in the 1950s [ 1 , 2 ] and a few diagnostic applications of 197 Hg occurred in the 1970s [ 3 , 4 ]. Back then, radiomercury was produced using reactor neutrons and had a low specific activity.…”