Administration of large doses of Hg203-labeled chlormerodrin to rats does not lower the P/O ratio of isolated kidney mitochondria. In vitro addition of chlormerodrin will lower the P/O ratio of rat kidney mitochondria, but only in concentrations greater than can be found by measurement of the mitochondrial radiomercury content following intramuscular injection. These techniques fail to demonstrate an in vivo effect of chlormerodrin upon oxidative phosphorylation by rat kidney mitochondria.
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