Comparison of Melatonin and Ozone in the Prevention of Reperfusion Injury Following Unilateral Testicular Torsion in Rats

Ekici, Sinan; Ekici, A. Işın Doğan; Öztürk, Güler; Aksungar, Fehime Benli; Sinanoğlu, Orhun; Turan, Güven; Lüleci, Nurettin

doi:10.1016/j.urology.2012.06.049

Cited by 36 publications

(30 citation statements)

References 27 publications

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“…using a testicular torsion model, IRI, intraperitoneal ozone therapy, and melatonin application were compared 19. In the melatonin treatment group, a decrease in NO level was observed, and in the ozone therapy group, an increase in NO level was observed.…”

Section: Discussionmentioning

confidence: 99%

Comparison of intraperitoneal and intratesticular ozone therapy for the treatment of testicular ischemia-reperfusion injury in rats

et al. 2017

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We compare the efficacy of intratesticular ozone therapy with intraperitoneal ozone therapy in an experimental rat model. For this purpose, 24 rats were divided into four groups including sham-operated, torsion/detorsion, torsion/detorsion plus intraperitoneal ozone (O-IP), and torsion/detorsion plus intratesticular ozone (O-IT). The O-IP ozone group received a 4 mg kg−1 intraperitoneal injection of ozone, and the O-IT group received the same injection epididymally. At 4 h after detorsion, the rats were sacrificed and orchiectomy materials were assessed histopathologically. Spermatogenesis in the seminiferous tubules and damage to the Sertoli cells were histopathologically evaluated in the testes using the Johnsen scoring system. i-NOS and e-NOS activities in the testis tissue were also evaluated. Torsion-detorsion caused a decreased Johnsen score and increased apoptosis of spermatogonial and Sertoli cells. Ozone injection prevented increases in Johnsen score and i-NOS level. e-NOS level of the O-IP group was significantly lower than that of the O-IP group, and i-NOS level of the O-IT group was significantly lower than that of the O-IP group. Local ozone therapy is more effective than systemic ozone therapy at improving IRI-related testicular torsion. Our study is the first to show that the efficacy of intratesticular implementation of ozone therapy is higher than that of intraperitoneal ozone therapy.

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Section: Discussionmentioning

confidence: 99%

Comparison of intraperitoneal and intratesticular ozone therapy for the treatment of testicular ischemia-reperfusion injury in rats

et al. 2017

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“…Ekici et al[97] assessed the potential effects of ozone in testicular function and morphology in a rat experimental study, in a mixture of ozone/oxygen and compared the results with those of melatonin. They found similar results in the amelioration of I/R injury between melatonin and ozone, but in different pathways.…”

Section: Searchmentioning

confidence: 99%

Antioxidants in experimental ischemia-reperfusion injury of the testis: Where are we heading towards?

Vaos

Zavras

2017

WJM

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Testicular torsion (TT) is a medical emergency that primary affects newborns and young adolescents. It causes testicular injury due to the torsion of the spermatic cord and its components, initially in the venous blood flow and finally in the arterial blood flow. Prompt diagnosis and early surgical management are necessary in managing this urgent situation. The process of the pathophysiological events in ischemia-reperfusion is multifactorial and deals with the perception of the oxidative stress responsible for the consequences of ischemia/reperfusion (I/R) stress following TT. Duration and severity of torsion also play a significant role in the oxidative stress. A detrimental result of the defense system of the testes takes place resulting finally in testicular atrophy and impaired function. Antioxidant factors have been experimentally studied in an effort to front this state. They have been classified as endogenous or exogenous antioxidants. Endogenous antioxidants comprise a structure of enzymic enzymatic and non-enzymic enzymatic particles presented within cytoplasm and numerous other subunits in the cells. Exogenous antioxidants include a variety of natural and pharmaceutical agents that may prevent or ameliorate the harmful effects of I/R injury. In this study we review those factors and their ability to enhance the oxidative status of the testis. A feature insight into where we are heading is attempted.

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“…11 When human blood is exposed to therapeutic O, the O dissolves in the plasma. 12 O reacts with certain substrates, such as polyunsaturated fatty acids and glutathione containing sulfhydryl (-SH) groups. This reaction, which produces hydrogen peroxide (H2O2) and lipid hydroperoxide at low concentrations, can activate protective cellular signaling pathways.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of ellagic acid and ozone on rat ovaries with an ischemia/reperfusion injury

Sayar

Biçer

Gürsul

et al. 2015

J of Obstet and Gynaecol

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Comparison of Melatonin and Ozone in the Prevention of Reperfusion Injury Following Unilateral Testicular Torsion in Rats

Cited by 36 publications

References 27 publications

Comparison of intraperitoneal and intratesticular ozone therapy for the treatment of testicular ischemia-reperfusion injury in rats

Comparison of intraperitoneal and intratesticular ozone therapy for the treatment of testicular ischemia-reperfusion injury in rats

Antioxidants in experimental ischemia-reperfusion injury of the testis: Where are we heading towards?

Protective effects of ellagic acid and ozone on rat ovaries with an ischemia/reperfusion injury

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