BackgroundThe aim of this study was to evaluate the prognostic importance of the metastatic lymph node ratio for stage III colon cancer patients and to find a cut-off value at which the overall survival and disease-free survival change.Material/MethodsPatients with pathological stage III colon cancer were retrospectively evaluated for: age; preoperative values of Crp, Cea, Ca 19-9, and Afp; pathologic situation of vascular, perineural, lymphatic, and serosal involvement; and metastatic lymph node ratio values were calculated.ResultsThe study included 58 stage III colon cancer patients: 20 (34.5%) females and 38 (65.5%) males were involved in the study. Multivariate analysis was applied to the following variables to evaluate significance for overall survival and disease-free survival: age, Crp, Cea, perineural invasion, and metastatic lymph node ratio. The metastatic lymph node ratio (<0.25 or ≥0.25) is the only independent variable significant for overall and disease-free survival.ConclusionsMetastatic lymph node ratio is an ideal prognostic marker for stage III colon cancer patients, and 0.25 is the cut-off value for prognosis.

The aim of this study was to investigate the possible protective role of antioxidant treatment with syringic acid (SA) on L-arginine-induced acute pancreatitis (AP) using biochemical and histopathologic approaches. A total of 30 rats were divided into 3 groups. The control group received normal saline intraperitoneally. The AP group was induced by 3.2 g/kg body weight L-arginine intraperitoneally, administered twice with an interval of 1 hour between administrations. The AP plus SA group, after having AP induced by 3.2 g/kg body weight L-arginine, was given SA (50 mg kg À1 ) in 2 parts within 24 hours. The rats were killed, and pancreatic tissue was removed and used in biochemical and histopathologic examinations. Compared with the control group, the mean pancreatic tissue total oxidant status level, oxidative stress index, and lipid hydroperoxide levels were significantly increased in the AP group, being 30.97 6 7.13 (P , 0.05), 1.76 6 0.34 (P , 0.0001), and 19.18 6 4.91 (P , 0.01), respectively. However, mean total antioxidant status and sulfhydryl group levels were significantly decreased in the AP group compared with the control group, being 1.765 6 0.21 (P , 0.0001) and 0.21 6 ), peroxynitrite, and other nitrates, whereas carbon-centered molecules are rather complex in terms of their chemical structure and generally are produced in the xenobiotic metabolism.2 Normally, there is a delicate balance between ROS and RNS production and tissue concentrations of antioxidants in the body. This balance is related to the rate of total antioxidant status (TAS) to total oxidant status (TOS), as determined by the oxidative stress index (OSI). ROS are produced both normally through the electron transfer chain system of the mitochondria and in excessive numbers in various conditions that increase energy (ATP) demand. The latter may include, among other factors, biologic factors and exposure to heat and certain chemicals and toxins. [3][4][5] ROS plays an important role in the pathogenesis of AP, and there is also a correlation between the production of ROS and the severity of AP. The detrimental effects of ROS and RNS are mediated by their direct actions on biomolecules, such as lipids, proteins, and DNA, and the activation of proinflammatory signal cascades, which subsequently lead to the activation of immune responses. 2The dietary plant polyphenolic compounds were shown to have beneficial effects in preventing oxidative stress, inhibiting the production of free radicals and the formation of lipid peroxidation.Scientific interest in phenolic compounds has been stimulated because of their anti-inflammatory, antimutagenic, and anticarcinogenic properties. They have antioxidant activity mainly due to their redox properties, which allow them to act as reducing agents, hydrogen donors, free radical scavengers, metal chelators, and modulators of enzymatic activity, thereby preventing a lot of diseases, including diabetes mellitus, hypertension, atherosclerosis, and cancer. 6,7 Antioxidants are compounds that, even when presen...

Ozone alone or combined with naringin has a protective effect for mesenteric ischemia. Instead of using instruments such as clamps in the II/R rat model, silk binding may be used safely.

These biochemical and histopathological findings suggest that EA and O are effective against ovarian I/R injury.

Biomarkers such as mismatch repair proteins, CDX2, p53, and E-cadherin are blamed for colon cancers, but the relationships of these biomarkers with each other and with pathological risk factors in colon carcinoma are still not clear. The aim of this study was to evaluate the association of these biomarkers with each other by using immunohistochemical staining and to compare their expression with pathological risk factors for colonic adenocarcinoma. We also aimed to study the usability of a double panel of mismatch repair proteins. One hundred and eleven cases with colonic adenocarcinoma were examined. There was a statistically significant relationship between tumor histological differentiation and perineural invasion, vascular invasion, mismatch repair deficiency, p53, CDX2, and E-cadherin (p < 0.05). PMS2 and MSH6 loss covered 100% of cases with mismatch repair deficiency. Mismatch repair deficiency was correlated with CDX2 loss and E-cadherin expression (p < 0.05). It was also observed that cases with PMS2 loss covered all the cases with CDX2 loss. In conclusion, this double panel may be used instead of a quadruple panel for detecting mismatch repair deficiency. Association of CDX2 and PMS2 in the present study is necessary to conduct further genetic and pathological studies focusing on these two markers together.

Patient: Male, 70Final Diagnosis: Esophageal perforationSymptoms: Abdominal pain • nausea • vomitingMedication: —Clinical Procedure: —Specialty: SurgeryObjective:Unusual clinical courseBackground:Esophageal perforation is a well-defined and severe clinical condition. There are several etiologies of esophagus perforation.Case Report:We report the case of a 70-year-old Caucasian man who underwent an emergency cholecystectomy due to acute cholecystitis. Two days after surgery, his condition deteriorated. Thorax computerized tomography revealed an esophageal perforation.Conclusions:Esophageal perforation due to nasogastric application is relatively rare but the consequences are potentially serious. The anatomy of the upper gastrointestinal system should be understood by all healthcare professionals involved in the treatment.

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Background:Intraperitoneal adhesion formation is a serious postsurgical issue. Adhesions develop after damage to the peritoneum by surgery, irradiation, infection or trauma.Objectives:Using a rat model, we compared the effectiveness of systemic and intraperitoneally administered common immunosuppressive drugs for prevention of postoperative intraperitoneal adhesions.Materials and Methods:Peritoneal adhesions were induced in 98 female Wistar-Albino rats by cecal abrasion and peritoneal excision. Rats were randomly separated into seven groups, each containing fourteen rats, and the standard experimental model was applied to all of rats. 14 days later, rats were euthanized, intraperitoneal adhesions were scored and tissues were examined histologically using hematoxylin/eosin and Masson’s trichrome staining.Results:Throughout the investigation, no animal died during or after surgery. In all of experimental groups, decrease in fibrosis was statistically significant. Decrease in fibrosis was most prominently in intraperitoneal tacrolimus group (P = 0.000), and decrease was least in intraperitoneal cyclosporine group (P = 0.022). Vascular proliferation was significantly decreased in all experimental groups (P < 0.05) except for systemic tacrolimus group (P = 0.139). Most prominent reduction in vascular proliferation was in intraperitoneal tacrolimus group (P = 0.000).Conclusions:Administration of immunosuppressive drugs is effective for prevention of intraperitoneal adhesions.