2015
DOI: 10.1016/j.ijsu.2015.07.012
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The effect of ozone and naringin on intestinal ischemia/reperfusion injury in an experimental model

Abstract: Ozone alone or combined with naringin has a protective effect for mesenteric ischemia. Instead of using instruments such as clamps in the II/R rat model, silk binding may be used safely.

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Cited by 43 publications
(38 citation statements)
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References 34 publications
(6 reference statements)
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“…Second, our research is based on an animal model, but clinical applications are needed. Finally, Rg1, similar to ozone26, may trigger the healing process after intestinal I/R injury, and we may explore this in future studies.…”
Section: Discussionmentioning
confidence: 98%
“…Second, our research is based on an animal model, but clinical applications are needed. Finally, Rg1, similar to ozone26, may trigger the healing process after intestinal I/R injury, and we may explore this in future studies.…”
Section: Discussionmentioning
confidence: 98%
“…Regarding the multifactorial pathogenesis of the disease local tissue ischemia is one of the most important risk factors. This causes weakness of the fascia and finally incisional hernia [4,5]. In addition, there are more rare causes, such as immunosuppression, diseases of the collagen metabolism and connective tissue diseases (e.g.…”
Section: Reviewmentioning
confidence: 99%
“…Otro mecanismo por el cual el tratamiento en la cámara hiperbárica favorece la curación de las lesiones por isquemia-reperfusión es que amplifica los gradientes de oxígeno en la periferia de las heridas isquémicas y con ello promueve la angiogé-nesis, la cual requiere la formación de matriz de colágena, misma que a su vez es dependiente del oxí-geno. Finalmente, la terapia con oxígeno hiperbárico permite la redistribución del flujo sanguíneo debido a las diferencias en los gradientes, y por ello alivia el edema que se genera en los tejidos dañados, con lo cual se reduce el dolor y se mejora la función [19][20][21][22][23] . Es principalmente por las leyes físicas aquí expuestas, y las vías fisiológicas y fisiopatológicas involucradas, que la medicina hiperbárica ofrece beneficios para los problemas de salud que involucran dichas vías.…”
Section: Bases Físicas Y Fisiológicas De La Terapia Con Oxigenación Hunclassified