Comparison of Lipid Profile in Type-2 Obese Diabetics and Obese Non-diabetic Individuals. A hospital Based Study from Western Nepal

Yadav, Neelu; Thanpari, C; Shrewastwa, Mukesh Kumar; Rk, Mittal

doi:10.3126/kumj.v10i3.8017

Cited by 22 publications

(20 citation statements)

References 25 publications

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“…In a study obese type-2 diabetic patients when compared to obese control subjects showed statistically significant increase in the levels of serum total cholesterol (p < 0.001), serum triglycerides (p < 0.001), serum LDL-cholesterol (p < 0.001) while serum HDL-cholesterol levels did not show statistically significant difference in the two group (p > 0.05) [28]. Another study showed that obesity is permanently associated with unhealthy lipid profile characterized by high triglycerides and LDL-C, and low HDL-C [2].…”

Section: Discussionmentioning

confidence: 90%

Effect of Body Mass Index on Lipid Profile of Type 2 Diabetic Patients at An Urban Tertiary Hospital In Nigeria

Omotoye¹,

Fadupin²

2016

IOSR

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Section: Discussionmentioning

confidence: 90%

Effect of Body Mass Index on Lipid Profile of Type 2 Diabetic Patients at An Urban Tertiary Hospital In Nigeria

Omotoye¹,

Fadupin²

2016

IOSR

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“…Over 300 million people are estimated to be obese. As a result, up to 1.7 billion of the world's population is at an increased risk of other lifethreatening diseases such as heart attack and stroke [4,5]. Obesity means accumulation of excess fat on the body.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Serum Lipid Profile Of Obese And Non-Obese Students (Male) Of Aljouf University

Khan¹,

Khaleel²

2016

Int J of Biomed & Adv Res

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Background: The prevalence of obesity has risen dramatically in past several decades. Hormonal and genetic factor are rarely the cause of childhood obesity. Because obese adult may suffer lifelong physical and emotional consequences, this imperative to discuss prevention with parents during well-child examinations. Objectives: Purpose of the study was to compare the Serum lipid profile of obese and non-obese males. Materials and methods: Twenty two male students were selected from AL-Jouf University. Their age ranged from19 to 29 years. They were divided into groups. One group (N=15) having more than 20% fat was considered as obese group, another group (N=7) was considered as non-obese group. Fasting blood samples were analyzed for blood cholesterol, triglycerides, low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C), using chemistry analyzer, BS-300 Chemistry Analyzer. Results: Of obese group, significant higher cholesterol and triglycerides were observed compared to non obese group. On the contrary, obese group had significant lower HDL-C concentration than the non-obese group. The adult obese has relatively larger changes in serum lipids at any given level of obesity. Conclusion: On the average, the more fat, the more likely an individual will be dyslipidemic and to express elements of the metabolic syndrome. Increased triglycerides level in obese impaired lipolysis which reduced the HDL-C concentrations.

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“…Furthermore, Yadav et al [21], who compared obese diabetic and obese non-diabetic patients regarding their lipid parameters, found that the former group experienced statistically significant increase in the levels of serum total cholesterol, serum triglycerides, serum LDLcholesterol while serum HDL-cholesterol levels did not show statistically significant difference in the two groups. This latter finding in particular opposes the results of our study and may be explained by the different clinical and laboratory characteristics of the studied populations.…”

Section: Discussionmentioning

confidence: 99%

Study of interleukin-18 ( IL18 ) and high sensitive C - reactive protein ( CRP ) in type 2 diabetes ( T2D ) with or without obesity

Kamel*

El-Baz

Emam

et al. 2020

Arab Journal of Nuclear Sciences and Applications

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Both diabetes and obesity are associated with chronic low-grade inflammation. IL-18 is a cytokine that stimulates various cell types and has pleiotropic functions. It is elevated in obesity, metabolic syndrome and type 2 diabetes (T2D).The hypothesis that serum level of IL-18 and high sensitive C-reactive protein can be used as markers for presence of chronic low-grade inflammation in type 2 diabetes more than in obesity per se was tested. The study recruited 80 subjects. They comprised 20 diabetic obese cases (DM-OB group), 20 diabetic non-obese cases (DM-NOB group), : 20 non-diabetic obese cases (NDM-OB group) and 20 non-diabetic non-obese subjects (NDM-NOB group). All participants were submitted to careful history taking, through clinical investigations and laboratory assessment. It was found that hs-CRP was significantly high in DMOB group (3.4±0.5 mg/dl) followed by NDM-OB group (2.9±0.4 mg/dl) then DM-NOB group (2.3±0.3 mg/dl) and least in NDM-NOB (0.8±0.3 mg/dl). It was also found that serum IL-18 was significantly highest in DMOB group (397.8±33.9 pg/mL) followed by NDM-OB (368.8±26.7 pg/mL) group followed by DM-NOB group (335.9±18.4 pg/mL) and least in NDM-NOB group (281.1±22.9 pg/mL). Serum IL-18 levels are directly correlated with BMI, waist circumference, hip circumference and waist/hip ratio in all the studied groups and with HbA1c in the diabetic groups. It could be concluded that Serum IL-18 and hs-CRP are related to diabetes and obesity. They are associated with dyslipidemia, poor glycemic control, insulin resistance and impaired liver and renal functions

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Comparison of Lipid Profile in Type-2 Obese Diabetics and Obese Non-diabetic Individuals. A hospital Based Study from Western Nepal

Cited by 22 publications

References 25 publications

Effect of Body Mass Index on Lipid Profile of Type 2 Diabetic Patients at An Urban Tertiary Hospital In Nigeria

Effect of Body Mass Index on Lipid Profile of Type 2 Diabetic Patients at An Urban Tertiary Hospital In Nigeria

Comparative Study of Serum Lipid Profile Of Obese And Non-Obese Students (Male) Of Aljouf University

Study of interleukin-18 ( IL18 ) and high sensitive C - reactive protein ( CRP ) in type 2 diabetes ( T2D ) with or without obesity

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