Both diabetes and obesity are associated with chronic low-grade inflammation. IL-18 is a cytokine that stimulates various cell types and has pleiotropic functions. It is elevated in obesity, metabolic syndrome and type 2 diabetes (T2D).The hypothesis that serum level of IL-18 and high sensitive C-reactive protein can be used as markers for presence of chronic low-grade inflammation in type 2 diabetes more than in obesity per se was tested. The study recruited 80 subjects. They comprised 20 diabetic obese cases (DM-OB group), 20 diabetic non-obese cases (DM-NOB group), : 20 non-diabetic obese cases (NDM-OB group) and 20 non-diabetic non-obese subjects (NDM-NOB group). All participants were submitted to careful history taking, through clinical investigations and laboratory assessment. It was found that hs-CRP was significantly high in DMOB group (3.4±0.5 mg/dl) followed by NDM-OB group (2.9±0.4 mg/dl) then DM-NOB group (2.3±0.3 mg/dl) and least in NDM-NOB (0.8±0.3 mg/dl). It was also found that serum IL-18 was significantly highest in DMOB group (397.8±33.9 pg/mL) followed by NDM-OB (368.8±26.7 pg/mL) group followed by DM-NOB group (335.9±18.4 pg/mL) and least in NDM-NOB group (281.1±22.9 pg/mL). Serum IL-18 levels are directly correlated with BMI, waist circumference, hip circumference and waist/hip ratio in all the studied groups and with HbA1c in the diabetic groups. It could be concluded that Serum IL-18 and hs-CRP are related to diabetes and obesity. They are associated with dyslipidemia, poor glycemic control, insulin resistance and impaired liver and renal functions
Objectives: To find out whether there is a lipid profile changes in pregnant women with preeclampsia and if we can use these lipid profile changes as markers of the severity of preeclampsia (for follow up to avoid leaving the patient reaching ecplamptic stage). Design: A prospective case-control study. Setting: AL- Kadhimiya Teaching hospital/department of Obstetrics and Gynecology. Materials and Methods: The study included 120 pregnant women in the third trimester. They were divided into three groups. The study group consists of 60 preeclamptic and eclamptic women, 25 women had mild pre-eclampsia and 35 women with severe preeclampsia. The control group consists of 60 normotensive pregnant women. Blood sample was drown after 8-10 hours fasting. Triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol levels were measured. Results: Triglyceride and VLDL-C level of severe Preeclampsia group and mild Preeclampsia group was higher than the control group, but the difference between the severe PE group and the control group was statistically significant (p<0.05). Serum cholesterol in the severe PE group was significantly higher than in mild PE group and in the control group (p<0.05). LDL-C and HDL-C levels were determined similarly in all groups (p>0.05). A highly significant positive correlation between the level of proteinuria and serum cholesterol levels, LDL-C, TG and VLDL-C levels. While there was significantly negative correlation between proteinuria and HDL-C levels. Also, a significant positive correlation between the systolic-tension and serum cholesterol levels, TG, VLDL-C levels and among the diastolic-tension and with LDL-C, TG, VLDL-C levels. Conclusion: Changes in levels of lipid profile are related with preeclampsia, especially with severe preeclampsia.
5, T12-L1) in 2 (6.2%) of 5 patients and only 1 (3.1%) of them had typical CT findings including widening, irregularity and sclerosis at the L4-5 intervertebral space. Conclusion Spondylodiscitis may have variable clinical or radiological manifestations and imaging techniques are needed to identify this uncommon complication in patients with AS.
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