Comparative Study of Serum Lipid Profile Of Obese And Non-Obese Students (Male) Of Aljouf University

Khan, Mohammad Najmuddin; Khaleel, Mohamad

doi:10.7439/ijbar.v7i1.2933

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…In this study, there was a significant increase in total cholesterol, LDL-C, non-HDL-C and triglycerides in obese subjects with and without diabetes, while HDL-C was significantly decreased. The significant differences in lipid profile markers between the healthy and obese non-diabetic groups was in agreement with the study of Khan and Khaleel [ 37 ], who conducted a study on the Saudi population, while the study of Songa et al [ 38 ] showed no significant differences in lipid profile markers between healthy and obese non-diabetic groups. This was not in accord with the current results.…”

Section: Discussionsupporting

confidence: 90%

Inflammatory Biomarkers of Cardiometabolic Risk in Obese Egyptian Type 2 Diabetics

Barakat

Shora²,

El‐Deen

et al. 2017

Medical Sciences

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Inflammatory biomarkers provide a minimally invasive means for early detection and specific treatment of metabolic syndrome and related disorders. The objective of this work was to search for inflammatory biomarkers of cardiometabolic risk in obese type 2 diabetics. The study was performed on 165 persons attending the medical outpatient clinic of Ismailia General Hospital. Their mean age was (50.69 ± 10.15) years. They were divided into three groups. The control group was composed of 55 non-obese, non-diabetic healthy volunteers, 32 males and 23 females. Two study groups were included in this study: group 2 was composed of 55 obese, non-diabetic subjects, 25 males and 30 females matched for age and gender. All patients including the control were subjected to clinical history taking, a clinical examination for the measurement of body mass index (BMI). Investigations were carried out for fasting blood glucose, fasting serum insulin, insulin resistance (IR), the lipid profile, lipoprotein band lipoprotein phospholipase A2, and non-high-density lipoprotein cholesterol (non-HDL-C). Urea, albumin and creatinine analysis and liver function tests were performed, and a complete blood count (CBC) was taken. Hemoglobin A1C (HbA1C), serum high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were tested. There were statistically significant differences among the studied groups in terms of total cholesterol, non-HDL-C, high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), lipoprotein-associated phospholipase A2 and apolipoprotein B. The inflammatory biomarkers hs-CRP, IL-6 and TNF-α were significantly statistically increased in the study groups by (1.62 ± 0.99, 2.32 ± 1.11), (1.73 ± 1.14, 2.53 ± 1.34), and (1.87 ± 1.09, 2.17 ± 0.89) respectively, where p < 0.01. Significant positive correlation was found between Homeostatic Model Assessment (HOMA)-IR, hs-CRP and IL-6. There was a significant positive correlation between non-HDL and hs-CRP, IL-6 and TNF-α and triglycerides and hs-CRP. In conclusion, in this study, CRP, IL-6, and TNF-α were significantly elevated in obese Egyptian type 2 diabetics and were positively correlated with insulin resistance, non-HDL and triglycerides. These inflammatory biomarkers could help in the premature identification of obese type 2 diabetic patients at high cardiometabolic risk. Additionally, these biomarkers are critical for providing prognostics and the validity of future potential anti-inflammatory therapeutic modalities.

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Section: Discussionsupporting

confidence: 90%

Inflammatory Biomarkers of Cardiometabolic Risk in Obese Egyptian Type 2 Diabetics

Barakat

Shora²,

El‐Deen

et al. 2017

Medical Sciences

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“…These results are in accordance with the study of Khan et al, which found significantly higher LDL levels in obese men compared to non-obese men (p<0.05). 30 Aljaffar's research (2018) also found significantly higher LDL levels in the obese group compared to the non-obese group (p≤0.05). 31 Research by Kanwar et al found that there was a significant difference in LDL in the obese compared to non-obese groups with p < 0.0001.…”

Section: Discussionmentioning

confidence: 87%

The Differences of Lipoprotein-Associated Phospholipase A2, Apolipoprotein B and Low Density Lipoprotein In Obese and Lean Men

Yuliana

Adipireno

Limijadi

et al. 2021

J. Biomed. Transl. Res.

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Background: An increase in fat accumulation in obesity has been suggested to link with an increase in inflammation. This inflammation may be associated with an elevated of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2), Apolipoprotein B (Apo B), and Low-Density Lipoprotein (LDL), thereby associated with the risk of atherosclerosis.Objective: To investigate the differences between Lp-PLA2, Apo B, and LDL levels in obese and lean men.Methods: A cross-sectional study was conducted on 74 men (obese and lean) at the Faculty of Medicine, Diponegoro University, Indonesia, in 2020. The concentration of LDL was measured using the homogenous enzymatic colourimetric method, whereas the levels of Lp-PLA2 and Apo B were determined using the ELISA method. Data were analyzed using an Independent t-test, setting statistical significance at p <0.05.Results: This study showed that Lp-PLA2 levels were significantly different between obese and lean men (p = 0.039). Furthermore, LDL levels were also significantly different between obese and lean men (p = 0.002). However, we did not find any differences in Apo B between obese and lean men (p = 0.640).Conclusion: Lp-PLA2 and LDL levels were slightly higher in obese compared to lean men, but no difference of Apo B.

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“…Adverse lipid changes associated with weight gain are implicated in the development cardiovascular complications with a high mortality and morbidity. 8 Nutritional manipulation of lipid profile is an emerging modality with therapeutic and preventive value. The present study looked at the effect of almond supplementation on serum lipid values in obese and overweight individuals and compared them with adults having normal weight.…”

Section: Discussionmentioning

confidence: 99%

“…5,6 Obese and overweight individuals are generally more prone to metabolic disruptions such as hyperglycemia, insulin resistance and dyslipidemias. [7][8][9] Dyslipidemias are common in developed countries where obesity is more prevalent. 10 Dyslipidemias are a primary risk factor for cardiovascular and metabolic disorders.…”

Section: Introductionmentioning

confidence: 99%

A comparative study of regular almond consumption’s effect on lipid profile in normal, Overweight and Obese adults.

Tahir¹,

Nawaz²,

Sikandar³

et al. 2019

TPMJ

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Objectives: Obesity is a globally pervasive health concern linked to a plethora of cardiometabolic complications such as hypertension, dyslipidemia and hyperglycemia. Poor dietary proclivity contributes to dyslipidemia, however daily intake of nuts has previously been shown to improve abnormal blood lipid levels. The present study evaluated the effect of almond intake on the lipid profiles of normal, overweight and obese adults to discern which group benefits the most. Study Design: A prospective non-randomized comparative study design was employed. Setting: Institute of Molecular Biology and Biochemistry, University of Lahore and Department of Biochemistry, Central Park Medical College, Lahore. Period: May 2018 and December 2018. Material & Methods: A total of 34 adult subjects (males and females) were recruited for the study with an age range from 21 to 60 years. Participants were categorized into normal, overweight and obese groups based on their Body Mass Index (BMI) values. Baseline fasting blood samples were drawn from each subject and stored. The subjects were then asked to consume 50g/day almonds (without peel) for 30 days after which blood samples were again collected from each subject. Both baseline and post-supplementation serum samples were subjected to lipid profile analysis. Result: Almond supplementation resulted in lowered cholesterol, LDL and VLDL levels (p-values of 0.0001, 0.001 and 0.003, respectively) in Group 1 (normal weight). Lowered cholesterol levels were also observed (p-value 0.007) in Group 2 (overweight). There was no significant change in lipid profile in Group 3 (overweight), upon supplementation. Conclusion: Regular almond supplementation offers improvement in lipid profile and such beneficial effects of almond consumption on lipid profile are more pronounced in normal weight individuals than overweight or obese ones.

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Comparative Study of Serum Lipid Profile Of Obese And Non-Obese Students (Male) Of Aljouf University

Cited by 4 publications

References 14 publications

Inflammatory Biomarkers of Cardiometabolic Risk in Obese Egyptian Type 2 Diabetics

Inflammatory Biomarkers of Cardiometabolic Risk in Obese Egyptian Type 2 Diabetics

The Differences of Lipoprotein-Associated Phospholipase A2, Apolipoprotein B and Low Density Lipoprotein In Obese and Lean Men

A comparative study of regular almond consumption’s effect on lipid profile in normal, Overweight and Obese adults.

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