Comparative analysis of GDF 8 (myostatin) in<i>Bos indicus</i>and<i>Bos taurus</i>

Tantia, M. S.; Vijh, R. K.; Kumar, S T Bharani; Mishra, Bina; Reecy, James M.

doi:10.1080/10425170600807603

Cited by 8 publications

(11 citation statements)

References 7 publications

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“…This insertion sequence (GAGTAGATTATGGCTT) (He et al, 2011) is the same as that reported by Tantia et al (2006).…”

Section: Resultssupporting

confidence: 56%

“…Three, 7, and 4 polymorphisms in exons 1, 2, and 3, respectively, were identified in Nellore cattle (Grisolia et al, 2009). In an analysis of the myostatin genes of Bos indicus and B. taurus, Tantia et al (2006) identified SNPs and an insertion mutation in B. indicus. Baron et al (2012) sequenced exon 2 of the myostatin gene in 332 horses of 20 different breeds and compared it against horse myostatin gene sequence deposited in GenBank.…”

Section: Introductionmentioning

confidence: 99%

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Comparative analysis of myostatin gene and promoter sequences of Qinchuan and Red Angus cattle

He¹,

Wu²,

Quan³

et al. 2013

Genet. Mol. Res.

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ABSTRACT.To better understand the function of the myostatin gene and its promoter region in bovine, we amplified and sequenced the myostatin gene and promoter from the blood of Qinchuan and Red Angus cattle by using polymerase chain reaction. The sequences of Qinchuan and Red Angus cattle were compared with those of other cattle breeds available in GenBank. Exon splice sites were confirmed by mRNA sequencing. Compared to the published sequence (GenBank accession No. AF320998), 69 single nucleotide polymorphisms (SNPs) were identified in the Qinchuan myostatin gene, only one of which was an insertion mutation in Qinchuan cattle. There was a 16-bp insertion in the first 705-bp intron in 3 Qinchuan cattle. A total of 7 SNPs were identified in exon 3, in which the mutation occurred in the third base of the codon and was synonymous. On comparing the Qinchuan myostatin gene sequence to that of Red Angus cattle, a total of 50 SNPs were identified in the first and third exons. In addition, there were 18 SNPs identified in the Qinchuan cattle promoter region compared with those of other cattle

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“…This insertion sequence (GAGTAGATTATGGCTT) (He et al, 2011) is the same as that reported by Tantia et al (2006).…”

Section: Resultssupporting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Comparative analysis of myostatin gene and promoter sequences of Qinchuan and Red Angus cattle

He¹,

Wu²,

Quan³

et al. 2013

Genet. Mol. Res.

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“…All the mutations (nt 262, 418, 807, 869, 1045, and 1066) observed in this study were synonymous and reported previously in Qinchuan and Red Angus cattle breeds [11]. Tantia et al [27] sequenced the MSTN gene of Indian B. indicus breeds (i.e., Rathi, Deoni, Idduki, and Vatakara) and compared their sequences to B. taurus (GenBank Acc. AB076403).…”

Section: Discussionsupporting

confidence: 79%

Genetic variation in the first intron and exon of the myostatin gene in several Indonesian cattle populations

Prihandini¹,

Primasari²,

Aryogi³

et al. 2021

Vet World

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Background and Aim: Myostatin (MSTN), a member of the transforming growth factor-β family, is a negative regulator of muscle mass. This study aimed to detect the genetic variation of the 1160 bp fragment of exon 1 and part of intron 1 of the MSTN gene in several cattle populations raised in Indonesia. Materials and Methods: Polymerase chain reaction products of the MSTN gene amplified from 92 animals representing 10 cattle populations (Peranakan Ongole [PO], Belgian Blue x PO cross, Rambon, PO x Bali cross, Jabres, Galekan, Sragen, Donggala, Madura, and Bali) were sequenced, compared, and aligned with bovine MSTN of Bos taurus (GenBank Acc. No. AF320998.1) and Bos indicus (GenBank Acc. No. AY794986.1). Results: Four nucleotide substitutions (nt 1045 and 1066 in intron 1; nt 262 and 418 in exon 1) and two indels (nt 807 and 869 in intron 1) were synonymous mutations. Among these substitutions, only the nt 262G>C and nt 418A>G loci were polymorphic in all populations, except Bali cattle. The frequencies of the nt 262C (0.82) and nt 418A (0.65) alleles were highest. For the nt 262G>C locus, the CC genotype had the highest frequency (0.66) followed by GC (0.30) and CC (0.03). For the nt 418A>G locus, the AG genotype had the highest frequency (0.52) followed by AA (0.39) and GG (0.09). Conclusion: The results, showing genetic variations in exon 1 and intron 1 of the MSTN gene, might be helpful for future association studies.

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“…Baladi goat breed sequenced under accession number KY463686 against nucleotide database showed that highly similarity with Capra hircus myostatin gene complete cds, Capra hircus breeds Guizhou Black, Jianchang Black, Angora, Shannan White, Nubian and Yichang White) myostatin MSTN gene complete cds which investigated by Liu et al [22], [23]. Also, Capra hircus breeds (Guizhou Small Xiang myostatin (MSTN) gene complete cds according to Zhu et al [6] and Guizhou Black and Qianbei Ma myostatin (MSTN) gene partial cds according to Feng et al [7], [8] and high similarity with another species like Ovis aries haplotypes 2, 3, 4, 5, 6, 7, 8, 9 and 10 myostatin (MSTN) gene, intron 1, promoter region, exon 1,5′ UTR and partial cds, Ovis aries (GDF-8) gene complete cds by Clop et al [1], Bos taurus myostatin (MSTN) gene complete cds according to Martinez et al [14] and Bos indicus myostatin gene complete cds which reported by Tantia et al [12] with identity ranged from 96 to 99% and 100% query coverage under E value (0). There were gab in one bp means that this gab may resulted according to breed variance, there were a variable identity percentage with a lot of mammals.…”

Section: Resultsmentioning

confidence: 99%

Detection of myostatin gene MSTN in some goat breeds (Capra hircus)

Dowidar

El-Sayed

Elrefy

et al. 2018

Journal of Genetic Engineering and Biotechnology

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Till now not information about myostatin MSTN gene in Egyptian goat breeds. Here we show more information about MSTN in some Egyptian goat breeds to enrich the database with new sequences for Egyptian goat breeds. Our conducted study focused on detection and identifying the MSTN gene as a candidate gene of the muscles growth trait in three goat breeds (Zaraibi, Baladi and Damascus). We found the similarity between the registered sequences with the accession numbers KY463684 for Zaraibi and KY463685 for Baladi and Chinese goat breeds of the MSTN gene deposited with international gene banks by up to 99% and some other species including sheep, cows and bull breeds with percentages of 95 to 97% and between 95 to 99%, respectively. There is also a correlation between the sequences of the registered pieces of Baladi with KY463686 and Damascus and Chinese breeds with KY441464 of MSTN deposited with international gene banks by up to 99% and some other species including sheep and bull breeds at a ratio of 99% for two pieces. Results demonstrated the deposited sequences of object are part of intron 1, exon 2 is fully sequenced with Zaraibi and Baladi breeds; the intron 1, exon 1 with Baladi breed; and the intron 2, part of exon 3 with Damascus breed. Therefore, the Egyptian goat breeds consider national wealth can be used to develop breeding and improvement programs which helps in more applicable scopes like biotechnology, genetic engineering and molecular biology with the help of bioinformatics tools.

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Comparative analysis of GDF 8 (myostatin) inBos indicusandBos taurus

Cited by 8 publications

References 7 publications

Comparative analysis of myostatin gene and promoter sequences of Qinchuan and Red Angus cattle

Comparative analysis of myostatin gene and promoter sequences of Qinchuan and Red Angus cattle

Genetic variation in the first intron and exon of the myostatin gene in several Indonesian cattle populations

Detection of myostatin gene MSTN in some goat breeds (Capra hircus)

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