Combination of single particle ICP-QMS and isotope dilution analysis for the determination of size, particle number and number size distribution of silver nanoparticles

Sötebier, Carina; Kutscher, Daniel; Rottmann, Lothar; Jakubowski, Norbert; Panne, Ulrich; Bettmer, Jörg

doi:10.1039/c6ja00137h

Cited by 31 publications

(16 citation statements)

References 37 publications

(55 reference statements)

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“…However, substantial matrix effect on NPs can be problematic if NP suspensions for spICP-MS measurement are dispersed in biological or environmental media containing a high content of matrix (e.g., phosphate-buffered saline, sea water, etc. ), which may require sensitivity correction using isotopic dilution analysis [60] or matrix matched ionic standards [27]. For samples that need additional dilution in water or the proposed diluents from this study, the matrix effect on NPs is expected to be low.…”

Section: Resultsmentioning

confidence: 99%

Overcoming challenges in single particle inductively coupled plasma mass spectrometry measurement of silver nanoparticles

et al. 2017

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Single particle ICP-MS has evolved rapidly as a quantitative method for determining nanoparticle size and number concentration at environmentally relevant exposure levels. Central to the application of spICP-MS is a commonly used, but not rigorously validated, calibration approach based on the measured transport efficiency and the response of ionic standards. In this work, we present a comprehensive and systematic study of the accuracy, precision and robustness of spICP-MS using the rigorously characterized reference material (RM) 8017 (Polyvinylpyrrolidone Coated Nominal 75 nm Silver Nanoparticles), recently issued by the National Institute of Standards and Technology (NIST). We report for the first time, statistically significant differences in frequency-based and size-based measures of transport efficiency with NIST RM 8013 Gold Nanoparticles and demonstrate that the size-based measure of transport efficiency is more robust and yields accurate results for the silver nanoparticle RM relative to TEM-based reference values. This finding is significant, because the frequency-based method is more widely applied. Furthermore, we demonstrate that the use of acidified ionic standards improves measurement of ICP-MS Ag response, but does not degrade the accuracy of the results for AgNP suspensions in water or various other diluents. Approaches for controlling AgNP dissolution were investigated and are shown to effectively improve particle stability in dilute suspensions required for spICP-MS analysis, while minimally affecting the measured intensity and allowing for more robust analysis. This study is an important and necessary advancement toward full validation and adoption of spICP-MS by the broader research community.

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Section: Resultsmentioning

confidence: 99%

Overcoming challenges in single particle inductively coupled plasma mass spectrometry measurement of silver nanoparticles

et al. 2017

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“…Cl naturally can be found as 35 Cl (~76%) and 37 Cl (~24%). Since 75 ArCl and 77 ArCl should be formed proportionally in the plasma, there should be an about three times decreased signal for 77 ArCl if compared to the signal observed at mass 75. As can be seen in Figure 46, this is not the case.…”

Section: Potential Mass Interferences Of Detected Isotopesmentioning

confidence: 92%

“…Methods to measure nanoparticles using the popular sp-ICP-MS mode were already established in Dr. Jakubowskis' group (BAM division 1.1) and served as a starting point. [77][78][79] First tests were carried out using a quadrupole ICP-MS (iCAP Q, Thermo Fisher Scientific)…”

Section: Establishing Sc-icp-ms Methods and Testing Of Cell Tagging Pmentioning

confidence: 99%

“…The sample introduction transport efficiency for gold nanoparticles (60 nm, NIST) was determined using established methods to ~3%. 77 To test whether this sample introduction system works as well for bigger particles like cells, Eu doped polystyrene beads (CyTOF ® calibration beads, Next, the goal was to analyze THP-1 cells using the same approach. First tests to measure THP-1 cells tagged with Ir-DNA-intercalator and mDOTA-Ho failed, as only background was visible.…”

Section: Establishing Sc-icp-ms Methods and Testing Of Cell Tagging Pmentioning

confidence: 99%

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Quantification of metals in single cells by LA-ICP-MS: comparison of single spot analysis and imaging

Löhr

Traub

Wanka

et al. 2018

J. Anal. At. Spectrom.

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“…The compensation of NaCl matrix effects via this approach was investigated and confirmed by Sötebier et al. 89 But, with regard to independent single particle events it is important to collect a sufficient number of data to allow for an appropriate averaging and thus reduce errors in the isotope ratios.…”

Section: Materials Namementioning

confidence: 93%

ICP-MS for the analysis at the nanoscale – a tutorial review

Meermann

Nischwitz

2018

J. Anal. At. Spectrom.

166

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The scope of this tutorial review is (i) to provide an overview on ICP-MS based techniques for the analysis of ENPs and natural nanoparticles/colloids by (a) “stand alone” ICP-MS and (b) hyphenated techniques; (ii) highlighting the benefits and pitfalls of each technique as well as providing practical advice regarding method development; (iii) illustrating the possibilities and limitations of each technique by practical applications from the recent literature.

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Combination of single particle ICP-QMS and isotope dilution analysis for the determination of size, particle number and number size distribution of silver nanoparticles

Abstract: Successful compensation of matrix effects by a combination of single particle ICP-MS and isotope dilution analysis.

Cited by 31 publications

References 37 publications

Overcoming challenges in single particle inductively coupled plasma mass spectrometry measurement of silver nanoparticles

Overcoming challenges in single particle inductively coupled plasma mass spectrometry measurement of silver nanoparticles

Quantification of metals in single cells by LA-ICP-MS: comparison of single spot analysis and imaging

ICP-MS for the analysis at the nanoscale – a tutorial review

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